Results 1 to 10 of about 18,763 (263)

Septins function in exocytosis via physical interactions with the exocyst complex in fission yeast cytokinesis [PDF]

eLife
Septins can function as scaffolds for protein recruitment, membrane-bound diffusion barriers, or membrane curvature sensors. Septins are important for cytokinesis, but their exact roles are still obscure.
Davinder Singh, Yajun Liu, Yi-Hua Zhu, Sha Zhang, Shelby M Naegele, Jian-Qiu Wu   +5 more
doaj   +4 more sources

A Septin Cytoskeleton-Targeting Small Molecule, Forchlorfenuron, Inhibits Epithelial Migration via Septin-Independent Perturbation of Cellular Signaling [PDF]

Cells, 2019
Septins are GTP-binding proteins that self-assemble into high-order cytoskeletal structures, filaments, and rings. The septin cytoskeleton has a number of cellular functions, including regulation of cytokinesis, cell migration, vesicle trafficking, and ...
Lei Sun, Xuelei Cao, Susana Lechuga, Alex Feygin, Nayden G. Naydenov, Andrei I. Ivanov   +5 more
doaj   +2 more sources

Septin higher-order structure on yeast membranes in vitro [PDF]

Nature Communications
Septins are cytoskeletal proteins that form filaments and higher-order structures, and remodel membranes in a variety of processes. Structural and cell biological studies provided atomic- and micro-scale details, but the understanding of septin assembly ...
James A. Goodchild, Brandy N. Curtis, Yangang Pan, Yining Jiang, Fang Jiao, Amy S. Gladfelter, Simon Scheuring   +6 more
doaj   +2 more sources

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. [PDF]

PLoS Genetics, 2014
Cytokinesis terminates mitosis, resulting in separation of the two sister cells. Septins, a conserved family of GTP-binding cytoskeletal proteins, are an absolute requirement for cytokinesis in budding yeast.
Manoj B Menon, Akihiro Sawada, Anuhar Chaturvedi, Pooja Mishra, Karin Schuster-Gossler, Melanie Galla, Axel Schambach, Achim Gossler, Reinhold Förster, Michael Heuser, Alexey Kotlyarov, Makoto Kinoshita, Matthias Gaestel   +12 more
doaj   +6 more sources

The evolutionary origins and ancestral features of septins [PDF]

Frontiers in Cell and Developmental Biology
Septins are a family of membrane-associated cytoskeletal guanine-nucleotide binding proteins that play crucial roles in various cellular processes, such as cell division, phagocytosis, and organelle fission.
Samed Delic, Brent Shuman, Shoken Lee, Shirin Bahmanyar, Michelle Momany, Masayuki Onishi   +5 more
doaj   +2 more sources

Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter [PDF]

BMC Cancer, 2018
Background The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM).
Walter Blum, László Pecze, Janine Wörthmüller Rodriguez, Martine Steinauer, Beat Schwaller   +4 more
doaj   +2 more sources

Localization and function of septins are susceptible to epitope tagging. [PDF]

Mol Biol Cell
Gregory JR, Llaneza IMA, Osmani AH, Gosselin HE, Sabzian SA, Wu JQ.   +5 more
europepmc   +3 more sources

The pathobiology of the septin gene family [PDF]

Journal of Pathology, 2004
Peter A. Hall, SE Hilary Russell
exaly   +2 more sources

Central Role of the Actomyosin Ring in Coordinating Cytokinesis Steps in Budding Yeast [PDF]

Journal of Fungi
Eukaryotic cells must accurately transfer their genetic material and cellular components to their daughter cells. Initially, cells duplicate their chromosomes and subsequently segregate them toward the poles.
Magdalena Foltman, Alberto Sanchez-Diaz
doaj   +2 more sources

Septin structure and filament assembly [PDF]

Biophysical Reviews, 2017
Ana Paula Ulian Araujo
exaly   +2 more sources