Results 11 to 20 of about 18,763 (263)

Mammalian Septins Nomenclature [PDF]

Molecular Biology of the Cell, 2002
There are 10 known mammalian septin genes, some of which produce multiple splice variants. The current nomenclature for the genes and gene products is very confusing, with several different names having been given to the same gene product and distinct ...
Kennedy, Mary B., Macara, Ian G.
core   +6 more sources

Septin mutations in human cancers [PDF]

Frontiers in Cell and Developmental Biology, 2016
Septins are GTP-binding proteins that are evolutionarily and structurally related to the RAS oncogenes. Septin expression levels are altered in many cancers and new advances point to how abnormal septin expression may contribute to the progression of ...
Elias T Spiliotis, Dimitrios Angelis
doaj   +3 more sources

Septins in Stem Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
Septins were first described in yeast. Due to extensive research in non-yeast cells, Septins are now recognized across all species as important players in the regulation of the cytoskeleton, in the establishment of polarity, for migration, vesicular ...
Tanja Schuster, Hartmut Geiger
doaj   +4 more sources

Randomized phase 2a trial assessing a novel septin molecular glue in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Pharmacological restoration of septin filament integrity has the potential to provide symptomatic benefit and disease modification in Alzheimer's disease (AD). METHODS REM127, a septin modulator, was assessed in mild‐to‐moderate AD (EudraCT: 2022‐000080‐43) in a phase 2a trial (n = 14).
Nuytten M, Voets M, Debroux E, Princen K, Pringels L, Fivaz M, Byl E, Ramael S, De Witte K, Boada M, Morató X, Tartari JP, Lafuente A, Macias EF, Matias-Guiu JA, Vijverberg E, Teunissen CE, Anderer P, Staggs V, Hayman V, Corbett A, Ballard C, Harrison JE, Windisch M, Westman AB, Zetterberg H, Dickson S, Mallinckrodt C, Hendrix S, Cummings J, Griffioen G.   +30 more
europepmc   +2 more sources

Coordinated regulation of Cdc42ep1, actin, and septin filaments during neural crest cell migration

Frontiers in Cell and Developmental Biology, 2023
The septin cytoskeleton has been demonstrated to interact with other cytoskeletal components to regulate various cellular processes, including cell migration. However, the mechanisms of how septin regulates cell migration are not fully understood.
Mary Kho, Siarhei Hladyshau, Siarhei Hladyshau, Denis Tsygankov, Denis Tsygankov, Shuyi Nie, Shuyi Nie   +6 more
doaj   +1 more source

Septins [PDF]

Current Biology, 2011
SummarySeptins are a family of proteins highly conserved in eukaryotes that have been under intense scrutiny lately because they appear to comprise a novel component of the cytoskeleton. As such, septins play important roles in many cellular processes by providing rigidity to the cell membrane, serving as scaffolds to recruit proteins to specific ...
Estey, Mathew P., Kim, Moshe S., Trimble, William S.   +2 more
openaire   +2 more sources

Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface

Frontiers in Cell and Developmental Biology, 2023
The septin family of eukaryotic proteins comprises distinct classes of sequence-related monomers that associate in a defined order into linear hetero-oligomers, which are capable of polymerizing into cytoskeletal filaments. Like actin and ⍺ and β tubulin,
Alya Hussain, Vu T. Nguyen, Philip Reigan, Michael McMurray   +3 more
doaj   +1 more source

Septin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia

Journal of Neuroinflammation, 2023
Background Septins are cytoskeletal proteins with filament forming capabilities, which have multiple roles during cell division, cellular polarization, morphogenesis, and membrane trafficking.
Ramona Miske, Madeleine Scharf, Kathrin Borowski, Nicole Rieckhoff, Bianca Teegen, Yvonne Denno, Christian Probst, Kersten Guthke, Ieva Didrihsone, Brigitte Wildemann, Klemens Ruprecht, Lars Komorowski, Sven Jarius   +12 more
doaj   +1 more source

Uncovering Principles That Control Septin-Septin Interactions [PDF]

Journal of Biological Chemistry, 2012
Septins comprise a conserved family of GTPases important in cytokinesis. These proteins polymerize into filaments from rod-shaped heteromeric septin complexes. Septins interact with one another at two interfaces (NC and G) that alternate within the complex.
Moshe S, Kim, Carol D, Froese, Hong, Xie, William S, Trimble   +3 more
openaire   +2 more sources

SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. [PDF]

PLoS Genetics, 2017
Septins are critical for numerous cellular processes through the formation of heteromeric filaments and rings indicating the importance of structural regulators in septin assembly.
Yi-Ru Shen, Han-Yu Wang, Yung-Che Kuo, Shih-Chuan Shih, Chun-Hua Hsu, Yet-Ran Chen, Shang-Rung Wu, Chia-Yih Wang, Pao-Lin Kuo   +8 more
doaj   +1 more source