Results 21 to 30 of about 18,763 (263)
Comparative Analysis of Septin Modifiers, Forchlorfenuron and
Cytoskeleton, EarlyView.ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky +4 more
openalex +2 more sources
iScience, 2022 Summary: The accumulation of lipid droplets (LDs) in the liver is a hallmark of steatosis, which is often associated with lysosomal dysfunction. Nevertheless, the underlying mechanisms remain unclear.
Pei Xuan Song +5 more
doaj +1 more source
Human septin–septin interaction: CDCrel‐1 partners with KIAA0202 [PDF]
FEBS Letters, 2002 Septins are evolutionary conserved cytoskeletal GTPases forming heteropolymer complexes involved in cytokinesis and other cellular processes. CDCrel‐1 (cell division cycle related‐1) is a recently cloned and characterized human septin which is highly expressed in non‐dividing cells, such as neurons.
Bläser, Susanne +6 more
openaire +3 more sources
Septins and Bacterial Infection [PDF]
Frontiers in Cell and Developmental Biology, 2016 Septins, a unique cytoskeletal component associated with cellular membranes, are increasingly recognized as having important roles in host defense against bacterial infection. A role for septins during invasion of Listeria monocytogenes into host cells was first proposed in 2002.
Torraca, V, Mostowy, S
openaire +5 more sources
Tugging at the Heart Strings: The Septin Cytoskeleton in Heart Development and Disease
Journal of Cardiovascular Development and Disease, 2020 Septin genes were originally identified in budding yeast in 1971. Since their original discovery, at least 13 mammalian genes have now been found, which give rise to a vast array of alternatively spliced proteins that display unique spatial-temporal ...
Kelsey Moore +3 more
doaj +1 more source
Human septin–septin interactions as a prerequisite for targeting septin complexes in the cytosol [PDF]
Biochemical Journal, 2004 Septins are a cytosolic GTP-binding protein family first characterized in yeast, but gaining increasing recognition as critical protagonists in higher eukaryotic cellular events. Mammalian septins have been associated with cytokinesis and exocytosis, along with contributing to the development of neurological disorders.
Constantino, Martínez +4 more
openaire +2 more sources
Contribution of septins to human platelet structure and function
iScience, 2022 Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim +5 more
doaj +1 more source
PLoS ONE, 2021 The cytokinetic contractile ring (CR) was first described some 50 years ago, however our understanding of the assembly and structure of the animal cell CR remains incomplete.
Chelsea Garno +7 more
doaj +1 more source
Turning it inside out: The organization of human septin heterooligomers. [PDF]
, 2019 Septin family proteins are quite similar to each other both within and between eukaryotic species. Typically, multiple discrete septins co-assemble into linear heterooligomers (usually hexameric or octameric rods) with a variety of cellular functions. We
Khairat J. E. +2 more
core +1 more source
Biochemical Characterization of a Human Septin Octamer
Frontiers in Cell and Developmental Biology, 2022 Septins are part of the cytoskeleton and polymerize into non-polar filaments of heteromeric hexamers or octamers. They belong to the class of P-loop GTPases but the roles of GTP binding and hydrolysis on filament formation and dynamics are not well ...
Martin Fischer +4 more
doaj +1 more source