Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region [PDF]
, 2004 Heat-shock protein 104 (Hsp104p) is a protein-remodeling factor that promotes survival after extreme stress by disassembling aggregated proteins and can either promote or prevent the propagation of prions (protein-based genetic elements).
Homann, Oliver R +3 more
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The Mammalian Septin Interactome [PDF]
Frontiers in Cell and Developmental Biology, 2017 Septins are GTP-binding and membrane-interacting proteins with a highly conserved domain structure involved in various cellular processes, including cytoskeleton organization, cytokinesis, and membrane dynamics. To date, 13 different septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14), which can be classified into four distinct ...
Neubauer, Katharina, Zieger, Barbara
openaire +3 more sources
The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation
eLife, 2013 Septins are guanine nucleotide-binding proteins that polymerize into filamentous and higher-order structures. Cdc42 and its effector Gic1 are involved in septin recruitment, ring formation and dissociation.
Yashar Sadian +6 more
doaj +1 more source
Identification of proteins in the postsynaptic density fraction by mass spectrometry [PDF]
, 2000 Our understanding of the organization of postsynaptic signaling systems at excitatory synapses has been aided by the identification of proteins in the postsynaptic density (PSD) fraction, a subcellular fraction enriched in structures with the morphology ...
Jensen, Ole N. +5 more
core +2 more sources
Phosphoregulation of Nap1 Plays a Role in Septin Ring Dynamics and Morphogenesis in
mBio, 2014 Nap1 has long been identified as a potential septin regulator in yeasts. However, its function and regulation remain poorly defined. Here, we report functional characterization of Nap1 in the human-pathogenic fungus Candida albicans.
Zhen-Xing Huang +5 more
doaj +1 more source
Regulation of septin phosphorylation: SEPT12 phosphorylation in sperm septin assembly [PDF]
Cytoskeleton, 2018 AbstractThe sperm annulus, a septin‐based ring structure, is important for reproductive physiology. It is composed of SEPT12‐based septin core complex followed by assembling as octameric filament. In clinical examinations, mutations of Septin12 result in male infertility, immotile sperm, as well as sperm with defective annuli.
Chun‐Hsiang Lin +5 more
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Glucose starvation triggers filamentous septin assemblies in an S. pombe septin-2 deletion mutant
Biology Open, 2019 Using correlative light and electron microscopy (CLEM), we studied the intracellular organization by of glucose-starved fission yeast cells (Schizosaccharomyces pombe) with regards to the localization of septin proteins throughout the cytoplasm. Thereby,
Minghua Liu +6 more
doaj +1 more source
The step-wise pathway of septin hetero-octamer assembly in budding yeast
eLife, 2017 Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers. Cells choose from a variety of available septins to assemble distinct hetero-oligomers, but the underlying mechanism was unknown.
Andrew Weems, Michael McMurray
doaj +1 more source
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry [PDF]
, 2018 Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathies, but the function of their ...
Aguirre +68 more
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Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the Elm1 kinase to the bud neck. [PDF]
PLoS Genetics, 2012 The first step towards cytokinesis in budding yeast is the assembly of a septin ring at the future site of bud emergence. Integrity of this ring is crucial for cytokinesis, proper spindle positioning, and the spindle position checkpoint (SPOC).
Laura Merlini +5 more
doaj +1 more source