Results 61 to 70 of about 1,311,103 (281)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Sequence Alignment Using Machine Learning-Based Needleman–Wunsch Algorithm

IEEE Access, 2021
Biological pairwise sequence alignment can be used as a method for arranging two biological sequence characters to identify regions of similarity. This operation has elicited considerable interest due to its significant influence on various critical ...
Amr Ezz El-Din Rashed, Hanan M. Amer, Mervat El-Seddek, Hossam El-Din Moustafa   +3 more
doaj   +1 more source

Pairwise alignment incorporating dipeptide covariation

, 2005
Motivation: Standard algorithms for pairwise protein sequence alignment make the simplifying assumption that amino acid substitutions at neighboring sites are uncorrelated.
Altschul, Altschul, Altschul, Altschul, Bailey, Bishop, Brenner, Cline, Crooks, DOOLITTLE, Frith, Fukami-Kobayashi, G. E. Crooks, Goldman, Gonnet, Henikoff, Henikoff, Jung, Karplus, Lin, Muller, Murzin, Park, Pearson, R. E. Green, RODIONOV, S. E. Brenner, Sander, Smith, Thorne, Thorne, Thorne, Topham, Weiss, Zachariah   +34 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Linking GPS and travel diary data using sequence alignment in a study of children's independent mobility

International Journal of Health Geographics, 2011
Background Global positioning systems (GPS) are increasingly being used in health research to determine the location of study participants. Combining GPS data with data collected via travel/activity diaries allows researchers to assess where people ...
Mavoa Suzanne, Oliver Melody, Witten Karen, Badland Hannah M   +3 more
doaj   +1 more source

Comparing and contrasting Escherichia coli and Mycobacterium tuberculosis mechanosensitive channels (MscL) - New gain of function mutations in the loop region [PDF]

, 2000
Sequence analysis of 35 putative MscL homologues was used to develop an optimal alignment for Escherichia coli and Mycobacterium tuberculosis MscL and to place these homologues into sequence subfamilies.
Dougherty, Dennis A., Elmore, Donald E., Lester, Henry A., Maurer, Joshua A.   +3 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

FPGA-based protein sequence alignment : A review

EPJ Web of Conferences, 2017
Sequence alignment have been optimized using several techniques in order to accelerate the computation time to obtain the optimal score by implementing DP-based algorithm into hardware such as FPGA-based platform.
Md. Isa Mohd. Nazrin, Ku Muhsen Ku Noor Dhaniah, Saiful Nurdin Dayana, Ahmad Muhammad Imran, Zainol Murad Sohiful Anuar, Mohyar Shaiful Nizam, Harun Azizi, Hussin Razaidi   +7 more
doaj   +1 more source

Fractal MapReduce decomposition of sequence alignment

Algorithms for Molecular Biology, 2012
Background The dramatic fall in the cost of genomic sequencing, and the increasing convenience of distributed cloud computing resources, positions the MapReduce coding pattern as a cornerstone of scalable bioinformatics algorithm development.
Almeida Jonas S, Grüneberg Alexander, Maass Wolfgang, Vinga Susana   +3 more
doaj   +1 more source