Results 71 to 80 of about 4,572,181 (334)
BMC Bioinformatics, 2011 Background Multiple Sequence Alignment (MSA) is a basic tool for bioinformatics research and analysis. It has been used essentially in almost all bioinformatics tasks such as protein structure modeling, gene and protein function prediction, DNA motif ...
Deng Xin, Cheng Jianlin
doaj +1 more source
Sequence Alignment Using Machine Learning-Based Needleman–Wunsch Algorithm
IEEE Access, 2021 Biological pairwise sequence alignment can be used as a method for arranging two biological sequence characters to identify regions of similarity. This operation has elicited considerable interest due to its significant influence on various critical ...
Amr Ezz El-Din Rashed +3 more
doaj +1 more source
Global Network Alignment [PDF]
, 2010 Motivation: High-throughput methods for detecting molecular interactions have lead to a plethora of biological network data with much more yet to come, stimulating the development of techniques for biological network alignment.
Natasa Przulj, Oleksii Kuchaiev
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Topological network alignment uncovers biological function and phylogeny
, 2009 Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact.
Cook S. +15 more
core +2 more sources
A Resistive CAM Processing-in-Storage Architecture for DNA Sequence Alignment [PDF]
IEEE Micro, 2017 A novel processing-in-storage (PRinS) architecture based on Resistive CAM (ReCAM) is described and proposed for Smith-Waterman (S-W) sequence alignment.
R. Kaplan +3 more
semanticscholar +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Ancestral sequence alignment under optimal conditions
BMC Bioinformatics, 2005 Background Multiple genome alignment is an important problem in bioinformatics. An important subproblem used by many multiple alignment approaches is that of aligning two multiple alignments. Many popular alignment algorithms for DNA use the sum-of-pairs
Brown Daniel G, Hudek Alexander K
doaj +1 more source
SeqKit2: A Swiss army knife for sequence and alignment processing
iMetaIn the era of ubiquitous high‐throughput sequencing studies, there is a growing need for analysis tools that are not just performant but also comprehensive and user‐friendly enough to cater to both novice and advanced users.
Wei Shen, Botond Sipos, Liuyang Zhao
semanticscholar +1 more source
Kalign 3: multiple sequence alignment of large datasets
Bioinform., 2019 Motivation Kalign is an efficient multiple sequence alignment (MSA) program capable of aligning thousands of protein or nucleotide sequences. However, current alignment problems involving large numbers of sequences are exceeding Kalign’s original design ...
T. Lassmann
semanticscholar +1 more source