Results 31 to 40 of about 2,925,732 (310)

Microcomputer programs for DNA sequence analysis [PDF]

Nucleic Acids Research, 1982
Computer programs are described which allow (a) analysis of DNA sequences to be performed on a laboratory microcomputer or (b) transfer of DNA sequences between a laboratory microcomputer and another computer system, such as a DNA library. The sequence analysis programs are interactive, do not require prior experience with computers and in many other ...
B, Conrad, D W, Mount
openaire   +2 more sources

The mutational repertoire of uterine sarcomas and carcinosarcomas in a Brazilian cohort: A preliminary study [PDF]

Clinics
OBJECTIVES: The present study aimed to contribute to the catalog of genetic mutations involved in the carcinogenic processes of uterine sarcomas (USs) and carcinosarcomas (UCSs), which may assist in the accurate diagnosis of, and selection of treatment ...
Leonardo Tomiatti da Costa, Laura Gonzalez dos Anjos, Luciane Tsukamoto Kagohara, Giovana Tardin Torrezan, Claudia A. Andrade De Paula, Edmund Chada Baracat, Dirce Maria Carraro, Katia Candido Carvalho   +7 more
doaj   +2 more sources

Seven-Cluster Structure of Larch Chloroplast Genome [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2015
The paper presents a novel approach to study a nucleotide sequence structure with respect to the chloroplast genome DNA sequence analysis. A specific frequencies distribution pattern of the consecutive triple nucleotide fragments was identified in the ...
Michael G. Sadovsky, Eugenia I. Bondar, Yulia A. Putintseva, Natalia V. Oreshkova, Eugene A. Vaganov, Konstantin V. Krutovsky   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Understanding the sequence-dependence of DNA groove dimensions: implications for DNA interactions. [PDF]

PLoS ONE, 2010
BACKGROUND: The B-DNA major and minor groove dimensions are crucial for DNA-protein interactions. It has long been thought that the groove dimensions depend on the DNA sequence, however this relationship has remained elusive.
Christophe Oguey, Nicolas Foloppe, Brigitte Hartmann   +2 more
doaj   +1 more source

Sequencing and Analysis of Neanderthal Genomic DNA [PDF]

Science, 2006
Our knowledge of Neanderthals is based on a limited number of remains and artifacts from which we must make inferences about their biology, behavior, and relationship to ourselves. Here, we describe the characterization of these extinct hominids from a new perspective, based on the development of a Neanderthal metagenomic library ...
Noonan, James P., Coop, Graham, Kudaravalli, Sridhar, Smith,Doug, Krause, Johannes, Alessi, Joe, Chen, Feng, Platt, Darren, Paabo,Svante, Pritchard, Jonathan K., Rubin, Edward M.   +10 more
openaire   +5 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

BioSeq-Analysis2.0: an updated platform for analyzing DNA, RNA and protein sequences at sequence level and residue level based on machine learning approaches

Nucleic Acids Research, 2019
As the first web server to analyze various biological sequences at sequence level based on machine learning approaches, many powerful predictors in the field of computational biology have been developed with the assistance of the BioSeq-Analysis. However,
B. Liu, Xin Gao, Han Zhang
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity. [PDF]

PLoS ONE, 2013
Rad54 is a dsDNA-dependent ATPase that translocates on duplex DNA. Its ATPase function is essential for homologous recombination, a pathway critical for meiotic chromosome segregation, repair of complex DNA damage, and recovery of stalled or broken ...
Xiao-Ping Zhang, Ryan Janke, James Kingsley, Jerry Luo, Clare Fasching, Kirk T Ehmsen, Wolf-Dietrich Heyer   +6 more
doaj   +1 more source