Results 21 to 30 of about 3,346,579 (352)
Towards Parsimonious Generative Modeling of RNA Families [PDF]
Nucleic Acids Research, gkae289 (2024), 2023 Generative probabilistic models emerge as a new paradigm in data-driven, evolution-informed design of biomolecular sequences. This paper introduces a novel approach, called Edge Activation Direct Coupling Analysis (eaDCA), tailored to the characteristics of RNA sequences, with a strong emphasis on simplicity, efficiency, and interpretability.
arxiv +1 more source
Power Analysis of Single Cell RNA-Sequencing Experiments [PDF]
Nature Methods, 2016 AbstractHigh-throughput single cell RNA sequencing (scRNA-seq) has become an established and powerful method to investigate transcriptomic cell-to-cell variation, and has revealed new cell types, and new insights into developmental process and stochasticity in gene expression.
Kedar Nath Natarajan +15 more
openaire +7 more sources
Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis
Frontiers in Oncology, 2020 Circular RNAs (circRNAs), as a burgeoning sort of non-coding RNAs (ncRNAs), can regulate the expression of parental genes as miRNA sponges. This study was designed to explore the circRNA expression profile of nasopharyngeal carcinoma (NPC).
Jing Yang +7 more
doaj +1 more source
Identification and sequence determination of a novel double-stranded RNA mycovirus from the entopathogenic fungus Beauveria bassina [PDF]
, 2015 The final publication is available at Springer via https://doi.org/10.1007/s00705-014-2332-8.An isolate of the entomopathogenic fungus Beauveria bassiana was found to contain five double-stranded (ds) RNA elements ranging from 1.5 to more than 3 kbp. The
Coutts, Robert H.A. +2 more
core +1 more source
Big Data Analytics in RNA-sequencing
Korean Journal of Clinical Laboratory Science, 2023 As next-generation sequencing has been developed and used widely, RNA-sequencing (RNA-seq) has rapidly emerged as the first choice of tools to validate global transcriptome profiling.
Sung-Hun WOO, Byung Chul JUNG
doaj +1 more source
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
Science, 2019 Somatic mosaicism in normal tissues Somatic cells can accumulate mutations over the course of an individual's lifetime. This generates cells that differ genetically at specific loci within the genome.
Keren Yizhak +19 more
semanticscholar +1 more source
RNA cytosine methylation analysis by bisulfite sequencing [PDF]
Nucleic Acids Research, 2008 Covalent modifications of nucleic acids play an important role in regulating their functions. Among these modifications, (cytosine-5) DNA methylation is best known for its role in the epigenetic regulation of gene expression. Post-transcriptional RNA modification is a characteristic feature of noncoding RNAs, and has been described for rRNAs, tRNAs and
Tim Pollex +3 more
openaire +3 more sources
Genome Research, 2016 RNA-seq protocols that focus on transcript termini are well suited for applications in which template quantity is limiting. Here we show that, when applied to end-sequencing data, analytical methods designed for global RNA-seq produce computational ...
Alan G. Derr +13 more
semanticscholar +1 more source
TT2NE: A novel algorithm to predict RNA secondary structures with pseudoknots [PDF]
, 2010 We present TT2NE, a new algorithm to predict RNA secondary structures with pseudoknots. The method is based on a classification of RNA structures according to their topological genus.
Bailor +29 more
core +4 more sources
ScanFold: an approach for genome-wide discovery of local RNA structural elements—applications to Zika virus and HIV [PDF]
PeerJ, 2018 In addition to encoding RNA primary structures, genomes also encode RNA secondary and tertiary structures that play roles in gene regulation and, in the case of RNA viruses, genome replication.
Ryan J. Andrews +2 more
doaj +2 more sources