Results 211 to 220 of about 31,098,092 (376)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Large language models for biological sequence analysis in infectious disease research. [PDF]

Biosaf Health
Luo J, Cai X, Li Y.
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Data From: Individual Movement - Sequence Analysis Method (Im-Sam): Characterising Spatio-Temporal Patterns Of Animal Trajectories Across Scales And Landscapes

, 2018
Johannes De Groeve, Francesca Cagnacci, Nathan Ranc, Nadège C. Bonnot, Benedikt Gehr, Marco Heurich, Max Kroeschel, John D. C. Linnell, Mark Hewison, Nicolas Morellet, Atle Mysterud, Robin Sandfort, Nico Van de Weghe   +12 more
openalex   +1 more source

Quantitative Analysis of Shallow Earthquake Sequences and Regional Earthquake Behavior: Implications for Earthquake Forecasting [PDF]

, 2013
Katrina Jacobs
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Sequence Analysis and Modeling of the Repetitive Region of the Long Isoform of Clarinet/CLA-1. [PDF]

MicroPubl Biol
Hunt B, Hunt T, Xuan Z.
europepmc   +1 more source

Additional file 1: of Vast diversity of prokaryotic virus genomes encoding double jelly-roll major capsid proteins uncovered by genomic and metagenomic sequence analysis

, 2018
Natalya Yutin, Disa BäCkstrĂśm, Thijs J. G. Ettema, Mart Krupovìč, Eugene V. Koonin   +4 more
openalex   +1 more source

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

Nature, 2000
The Arabidopsis Genome Initiative
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source