Results 221 to 230 of about 2,665,426 (306)

Viral sequence analysis of chronic hepatitis B patients treated with the siRNA JNJ-73763989 in phase II clinical trials. [PDF]

JHEP Rep
Verbinnen T, Lathouwers E, Jezorwski J, Biermer M, Augustyns I, Grant C, Agarwal K, Yuen MF, De Meyer S, Lenz O.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Mechanisms of USP18 specificity toward ISG15 revealed by paralog sequence analysis comparison. [PDF]

J Biol Chem
Bonacci T, Bolhuis DL, Brown NG, Emanuele MJ.   +3 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Service use patterns in community mental health outreach: A sequence analysis of the first 12-month longitudinal data. [PDF]

PLoS One
Iwanaga M, Usui K, Sato S, Nakanishi K, Nishiuchi E, Shimodaira M, So Y, Yamaguchi S, Fujii C.   +8 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Whole genome sequence analysis and characterization of virulent Newcastle disease virus isolates from chicken and pheasants during 2020/21 outbreaks in Nepal. [PDF]

Virol J
Prajapati M, Pokharel A, Rayamajhi S, Acharya MP, Aryal M, Karn S, James J, Banyard AC, Ross CS, Lynton-Jenkins JG.   +9 more
europepmc   +1 more source

Amino acid sequence analysis of thermostable endo-ß-1, 4-glucanase purified from Trichoderma viride

, 2011
Nidhee Chaudhary
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Palliative care pathways in Amyotrophic Lateral Sclerosis (ALS): a sequence analysis of health claims data. [PDF]

BMC Palliat Care
Schmidt R, Slotina E, Meissner F, Metelmann M, Ilse B, Vogt V, Freytag A.   +6 more
europepmc   +1 more source