Results 11 to 20 of about 5,730,601 (379)

Human Chromosome 7: DNA Sequence and Biology [PDF]

Science, 2003
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical ...
Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Hobeika Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, S. Gentles, Constantine Christopoulos, Sanaa Choufani, Dorota A. Kwasnicka, Xiangqun Zheng-Bradley, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Małgorzata J.M. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H.Q. Heng, Pier Giuseppe Pelicci, Francesco Lo‐Coco, Elena Belloni, Lisa G. Shaffer, Barbara R. Pober, Cynthia C. Morton, James F. Gusella, G.A.P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung‐Goo Kim, Anne Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, E.J.T. Winsor, Karl‐Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluı́s Armengol, Miguel Ángel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David Oscier, Sarah Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard Mural, Mark D. Adams, Lap-Chee Tsui   +89 more
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence [PDF]

Nature, 1998
Stewart T. Cole, R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, Clifton E. Barry, Fredj Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, Anders Krogh, Jack J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M.-A. Rajandream, Josh Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, B. G. Barrell   +41 more
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The anatomy of an aphid genome: From sequence to biology [PDF]

Comptes Rendus. Biologies, 2010
In 2009, the genome of the pea aphid (Acyrthosiphon pisum) was sequenced and partially annotated. This means that the scientific community has now access to the genetic material of aphids that are serious pests of plants. The description of an aphid genome is a first step to go deeper in the understanding of the biology of these insects.
Denis Tagu, Sébastien Dugravot, Yannick Outreman, Claude Rispe, Jean‐Christophe Simon, Stefano Colella   +5 more
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CLONEQC: lightweight sequence verification for synthetic biology [PDF]

Nucleic Acids Research, 2010
Synthetic biology projects aim to produce physical DNA that matches a designed target sequence. Chemically synthesized oligomers are generally used as the starting point for building larger and larger sequences. Due to the error rate of chemical synthesis, these oligomers can have many differences from the target sequence.
Pablo A. Lee, Jessica S. Dymond, Lisa Z. Scheifele, Sarah M. Richardson, Katrina J. Foelber, Jef D. Boeke, Joel S. Bader   +6 more
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Structural biology of metal-binding sequences

Current Opinion in Chemical Biology, 2002
NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and ...
Stanley J. Opella, Tara M. DeSilva, Gianluigi Veglia   +2 more
openalex   +4 more sources

Strainberry: automated strain separation in low-complexity metagenomes using long reads

Nature Communications, 2021
Existing long-read de novo assembly methods can partially, but not completely, separate strains. Here, the authors develop Strainberry, a metagenome assembly bioinformatic pipeline that exclusively uses longread data to accurately separate and ...
Riccardo Vicedomini, Christopher Quince, Aaron E. Darling, Rayan Chikhi   +3 more
doaj   +1 more source

decOM: similarity-based microbial source tracking of ancient oral samples using k-mer-based methods

Microbiome, 2023
Background The analysis of ancient oral metagenomes from archaeological human and animal samples is largely confounded by contaminant DNA sequences from modern and environmental sources.
Camila Duitama González, Riccardo Vicedomini, Téo Lemane, Nicolas Rascovan, Hugues Richard, Rayan Chikhi   +5 more
doaj   +1 more source

Predicting multiple conformations via sequence clustering and AlphaFold2

Nature, 2023
AlphaFold2 (ref. 1) has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein’s biological function often depends on multiple conformational substates2, and disease-causing point mutations often ...
Hannah K. Wayment-Steele, Adedolapo M Ojoawo, Renee Otten, Julia M Apitz, W. Pitsawong, Marc Hömberger, S. Ovchinnikov, Lucy J Colwell, Dorothee Kern   +8 more
semanticscholar   +1 more source

High‐throughput sequencing for biology and medicine [PDF]

Molecular Systems Biology, 2013
Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important ...
Michael Snyder, Wendy Weijia Soon, Manoj Hariharan   +2 more
openaire   +3 more sources

Impact of Nucleic Acid Sequencing on Viroid Biology [PDF]

International Journal of Molecular Sciences, 2020
The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis technique.
Charith Raj Adkar-Purushothama, Jean-Pierre Perreault   +1 more
openaire   +4 more sources