Results 31 to 40 of about 1,274,222 (313)

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis

npj Biofilms and Microbiomes, 2017
Psoriasis: investigating microbial diversity Analysing microbial populations on the skin provides an insight into the diversity of microbes associated with psoriasis.
Adrian Tett, Edoardo Pasolli, Stefania Farina, Duy Tin Truong, Francesco Asnicar, Moreno Zolfo, Francesco Beghini, Federica Armanini, Olivier Jousson, Veronica De Sanctis, Roberto Bertorelli, Giampiero Girolomoni, Mario Cristofolini, Nicola Segata   +13 more
doaj   +1 more source

The SH2 Domain Interaction Landscape

Cell Reports, 2013
Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines. Each domain displays a distinct preference for the sequence context of the phosphorylated residue.
Michele Tinti, Lars Kiemer, Stefano Costa, Martin L. Miller, Francesca Sacco, Jesper V. Olsen, Martina Carducci, Serena Paoluzi, Francesca Langone, Christopher T. Workman, Nikolaj Blom, Kazuya Machida, Christopher M. Thompson, Mike Schutkowski, Søren Brunak, Matthias Mann, Bruce J. Mayer, Luisa Castagnoli, Gianni Cesareni   +18 more
doaj   +1 more source

Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation

iScience, 2023
Summary: Copper is an essential component in the mitochondrial respiratory chain complex IV (cytochrome c oxidases). However, whether any nucleolar factor(s) is(are) involved in regulating the mitochondrial copper homeostasis remains unclear.
Jinsong Wei, Shuai Wang, Haozhe Zhu, Wei Cui, Jianan Gao, Ce Gao, Bo Yu, Bojing Liu, Jun Chen, Jinrong Peng   +9 more
doaj   +1 more source

Designing and evaluating a context-based lesson sequence promoting conceptual coherence in biology [PDF]

, 2015
Context-based education, in which students deal with biological concepts in a meaningful way, is showing promise in promoting the development of students conceptual coherence.
Sub Biology Education, Science and Mathematics Education, Ummels, M. H J, De Kroon, H., Boersma, K.T, Kamp, M.J.A., H. de Kroon, K.Th. Boersma, M.H.J. Ummels, Boersma, K. Th, M.J.A. Kamp, Kamp, M. J A, Ummels, M.H.J.   +12 more
core   +1 more source

Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

Scientific Reports, 2017
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Branka Radic-Sarikas, Melinda Halasz, Kilian V. M. Huber, Georg E. Winter, Kalliopi P. Tsafou, Theodore Papamarkou, Søren Brunak, Walter Kolch, Giulio Superti-Furga   +8 more
doaj   +1 more source

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

iScience, 2023
Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon   +7 more
doaj   +1 more source

TarO : a target optimisation system for structural biology

, 2008
This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim, Barton, Geoffrey J, Naismith, James H, William N. Hunter, White, Malcolm F, McMahon, Stephen, Hunter, William N., vanNiekerk, C. A. Johannes, Overton, Ian M., Hunter, William, van Niekerk, C. A. Johannes, van Niekerk, C A, Barton, Geoffrey, Carter, Lester, Geoffrey J. Barton, Naismith, James, Hunter, W N, Carter, Lester G., Overton, Ian; id_orcid, Dawson, Alice, McMahon, S A, Dawson, A, David M. A. Martin, McMahon, Stephen A., White, Malcolm F., Martin, David, Scott Cameron, White, Malcolm, Barton, G J, Cameron, Scott, Naismith, James H., Ian M. Overton, James H. Naismith, Cameron, S, Malcolm F. White, Barton, Geoffrey J.; id_orcid, Lester G. Carter, Carter, L G, Alice Dawson, Martin, D M, Martin, David M. A.; id_orcid, C. A. Johannes Van Niekerk, Stephen A. Mcmahon, Overton, I M, Overton, Ian   +44 more
core   +1 more source

Distinguishing regional from within-codon rate heterogeneity in DNA sequence alignments [PDF]

, 2009
We present an improved phylogenetic factorial hidden Markov model (FHMM) for detecting two types of mosaic structures in DNA sequence alignments, related to (1) recombination and (2) rate heterogeneity.
Husmeier, D., Mantzaris, Alexander Vassilios, Dirk Husmeier, Mantzaris, A.V., Alexander V. Mantzaris   +4 more
core   +1 more source

Integrating sequence and structural biology with DAS

BMC Bioinformatics, 2007
Background The Distributed Annotation System (DAS) is a network protocol for exchanging biological data. It is frequently used to share annotations of genomes and protein sequence.
Finn Robert D, Kulesha Eugene, Down Thomas A, Prlić Andreas, Kähäri Andreas, Hubbard Tim JP   +5 more
doaj   +1 more source

Natural variability of Kozak sequences correlates with function in a zebrafish model. [PDF]

PLoS ONE, 2014
In eukaryotes, targeting the small ribosomal subunit to the mRNA transcript requires a Kozak sequence at the translation initiation site. Despite the critical importance of the Kozak sequence to regulation of gene expression, there have been no ...
Steven J Grzegorski, Estelle F Chiari, Amy Robbins, Phillip E Kish, Alon Kahana   +4 more
doaj   +1 more source