Results 31 to 40 of about 2,275,975 (294)

Dissecting spatio‐temporal protein networks driving human heart development and related disorders

Molecular Systems Biology, 2010
Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems‐level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting
Kasper Lage, Kjeld Møllgård, Steven Greenway, Hiroko Wakimoto, Joshua M Gorham, Christopher T Workman, Eske Bendsen, Niclas T Hansen, Olga Rigina, Francisco S Roque, Cornelia Wiese, Vincent M Christoffels, Amy E Roberts, Leslie B Smoot, William T Pu, Patricia K Donahoe, Niels Tommerup, Søren Brunak, Christine E Seidman, Jonathan G Seidman, Lars A Larsen   +20 more
doaj   +1 more source

ANALYZING THE GENOMIC VARIATION OF MICROBIAL CELL FACTORIES IN THE ERA OF “NEW BIOTECHNOLOGY”

Computational and Structural Biotechnology Journal, 2012
The application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular,
Markus Herrgård, Gianni Panagiotou
doaj   +1 more source

EcoCyc: fusing model organism databases with systems biology. [PDF]

, 2012
EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César, Collado-Vides, Julio, Fulcher, Carol, Gama-Castro, Socorro, Gunsalus, Robert P, Huerta, Araceli M, Karp, Peter D, Keseler, Ingrid M, Kothari, Anamika, Krummenacker, Markus, Latendresse, Mario, Mackie, Amanda, Muñiz-Rascado, Luis, Ong, Quang, Paley, Suzanne, Paulsen, Ian, Peralta-Gil, Martin, Santos-Zavaleta, Alberto, Schröder, Imke, Shearer, Alexander G, Subhraveti, Pallavi, Travers, Mike, Weerasinghe, Deepika, Weiss, Verena   +23 more
core   +1 more source

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis

npj Biofilms and Microbiomes, 2017
Psoriasis: investigating microbial diversity Analysing microbial populations on the skin provides an insight into the diversity of microbes associated with psoriasis.
Adrian Tett, Edoardo Pasolli, Stefania Farina, Duy Tin Truong, Francesco Asnicar, Moreno Zolfo, Francesco Beghini, Federica Armanini, Olivier Jousson, Veronica De Sanctis, Roberto Bertorelli, Giampiero Girolomoni, Mario Cristofolini, Nicola Segata   +13 more
doaj   +1 more source

The SH2 Domain Interaction Landscape

Cell Reports, 2013
Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines. Each domain displays a distinct preference for the sequence context of the phosphorylated residue.
Michele Tinti, Lars Kiemer, Stefano Costa, Martin L. Miller, Francesca Sacco, Jesper V. Olsen, Martina Carducci, Serena Paoluzi, Francesca Langone, Christopher T. Workman, Nikolaj Blom, Kazuya Machida, Christopher M. Thompson, Mike Schutkowski, Søren Brunak, Matthias Mann, Bruce J. Mayer, Luisa Castagnoli, Gianni Cesareni   +18 more
doaj   +1 more source

Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation

iScience, 2023
Summary: Copper is an essential component in the mitochondrial respiratory chain complex IV (cytochrome c oxidases). However, whether any nucleolar factor(s) is(are) involved in regulating the mitochondrial copper homeostasis remains unclear.
Jinsong Wei, Shuai Wang, Haozhe Zhu, Wei Cui, Jianan Gao, Ce Gao, Bo Yu, Bojing Liu, Jun Chen, Jinrong Peng   +9 more
doaj   +1 more source

Decoding Sequence Classification Models for Acquiring New Biological Insights [PDF]

, 2010
Classifying biological sequences is one of the most important tasks in computational biology. In the last decade, support vector machines (SVMs) in combination with sequence kernels have emerged as a de-facto standard.
Andreas Kothmeier, Carsten Mahrenholz, Ingrid Abfalter, Sepp Hochreiter, Ulrich Bodenhofer, Ulrich Bodenhofer   +5 more
core   +2 more sources

100th Anniversary of Macromolecular Science Viewpoint: Opportunities in the Physics of Sequence-Defined Polymers [PDF]

, 2020
Polymer science has been driven by ever-increasing molecular complexity, as polymer synthesis expands an already-vast palette of chemical and architectural parameter space.
Perry, Sarah L., Sing, Charles E.
core   +3 more sources

Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

Scientific Reports, 2017
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Branka Radic-Sarikas, Melinda Halasz, Kilian V. M. Huber, Georg E. Winter, Kalliopi P. Tsafou, Theodore Papamarkou, Søren Brunak, Walter Kolch, Giulio Superti-Furga   +8 more
doaj   +1 more source

Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells

iScience, 2023
Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifying ...
Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon   +7 more
doaj   +1 more source