Results 51 to 60 of about 1,274,222 (313)

Sequence alignment, mutual information, and dissimilarity measures for constructing phylogenies

, 2011
Background: Existing sequence alignment algorithms use heuristic scoring schemes based on biological expertise, which cannot be used as objective distance metrics.
Penner, Orion, Grassberger, Peter, Maya Paczuski, Paczuski Maya, Peter Grassberger, Orion Penner, Penner Orion, Grassberger Peter, Paczuski, Maya   +8 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk

Nature Genetics, 2018
Key challenges for human genetics, precision medicine and evolutionary biology include deciphering the regulatory code of gene expression and understanding the transcriptional effects of genome variation.
Jian Zhou, Chandra L. Theesfeld, K. Yao, Kathleen M. Chen, A. Wong, O. Troyanskaya   +5 more
semanticscholar   +1 more source

Representation learning applications in biological sequence analysis

bioRxiv, 2021
Remarkable advances in high-throughput sequencing have resulted in rapid data accumulation, and analyzing biological (DNA/RNA/protein) sequences to discover new insights in biology has become more critical and challenging.
Hitoshi Iuchi, Taro Matsutani, Keisuke Yamada, Natsuki Iwano, Shunsuke Sumi, S. Hosoda, Shitao Zhao, Tsukasa Fukunaga, Michiaki Hamada   +8 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Sequence modeling and design from molecular to genome scale with Evo

bioRxiv
The genome is a sequence that completely encodes the DNA, RNA, and proteins that orchestrate the function of a whole organism. Advances in machine learning combined with massive datasets of whole genomes could enable a biological foundation model that ...
Eric Nguyen, Michael Poli, Matthew G. Durrant, Armin W. Thomas, Brian Kang, Jeremy Sullivan, Madelena Y. Ng, A. Lewis, Aman Patel, Aaron Lou, Stefano Ermon, S. Baccus, Tina Hernandez-Boussard, Christopher Ré, Patrick D. Hsu, Brian L. Hie   +15 more
semanticscholar   +1 more source

Synthetic biology open language (SBOL) version 3.0.0

Journal of Integrative Bioinformatics, 2020
Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems.
Baig Hasan, Fontanarrosa Pedro, Kulkarni Vishwesh, McLaughlin James Alastair, Vaidyanathan Prashant, Bartley Bryan, Beal Jacob, Crowther Matthew, Gorochowski Thomas E., Grünberg Raik, Misirli Goksel, Scott-Brown James, Oberortner Ernst, Wipat Anil, Myers Chris J.   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Hands-On Activity to Demonstrate the Central Dogma of Molecular Biology Via a Simulated VDJ Recombination Activity

Journal of Microbiology & Biology Education, 2017
Essential or enduring understandings are often defined as the underlying core concepts or “big ideas” we’d like our students to remember when much of the course content has been forgotten.
Pamela A. Marshall
doaj   +1 more source

Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]

, 2006
Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core   +1 more source