Results 61 to 70 of about 1,274,222 (313)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Rural Education and the teaching of genetics: an investigative didactic possibility

Revista Brasileira de Educação do Campo, 2021
Research related to the genome project, cloning and genetically modified organisms are present inside and outside the school. Such subjects deserve attention in the teaching of genetics due to the difficulties presented by the students, regarding the ...
Kássia Paula Oliveira da Silva, Lenicy Lucas de Miranda Cerqueira, Luciana Melhorança Moreira   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A computational pipeline to visualize DNA-protein binding states using dSMF data

STAR Protocols, 2022
Summary: Here, we present a pipeline to map states of protein-binding DNA in vivo. Our pipeline infers as well as quantifies cooperative binding. Using dual-enzyme single-molecule footprinting (dSMF) data, we show how our workflow identifies binding ...
Satyanarayan Rao, Srinivas Ramachandran
doaj   +1 more source

Control control control : a reassessment and comparison of GenBank and chromatogram mtDNA sequence variation in Baltic grey seals (Halichoerus grypus) [PDF]

, 2013
This study was funded by an ‘EU bonus’ award given to MTP Gilbert by the University of Copenhagen.Genetic data can provide a powerful tool for those interested in the biology, management and conservation of wildlife, but also lead to erroneous ...
Katharina Fietz, Jeff A. Graves, Olsen, Morten Tange, Katharina Fietz, Jeff A Graves, Fietz, Katharina, Graves, Jefferson Alden, Graves, Jeff A., Morten Tange Olsen   +8 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Alignment-free sequence comparison: benefits, applications, and tools

Genome Biology, 2017
Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences.
A. Zielezinski, S. Vinga, Jonas S. Almeida, W. Karłowski   +3 more
semanticscholar   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Panke, Sven, Heinemann, Matthias,, Panke, Sven,, Heinemann, Matthias   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Complete genome sequence and taxonomic position of anguillid herpesvirus 1

, 2010
Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp
Bossers, A., Voorbergen-Laarman, M.H., Dep Infectieziekten Immunologie, Rottier, P.J.M., van Beurden, S.J., Voorbergen-Laarman, H.A., Peeters, B.P.H., Strategic Infection Biology, Peeters, B.P., Peters, S., Peters, S.A., Haenen, O.L.M., Engelsma, M.Y., Beurden, S.J., van, Abma-Henkens, M.H.C.   +14 more
core   +1 more source