Results 61 to 70 of about 2,275,975 (294)

Geometric combinatorics and computational molecular biology: branching polytopes for RNA sequences

, 2016
Questions in computational molecular biology generate various discrete optimization problems, such as DNA sequence alignment and RNA secondary structure prediction.
Drellich, Elizabeth, Gainer-Dewar, Andrew, Harrington, Heather A., He, Qijun, Heitsch, Christine, Poznanović, Svetlana   +5 more
core   +1 more source

Evolutionary ecology of opsin gene sequence, expression and repertoire. [PDF]

, 2017
Linking molecular evolution to biological function is a long-standing challenge in evolutionary biology. Some of the best examples of this involve opsins, the genes that encode the molecular basis of light reception.
Owens, Gregory L, Rennison, Diana J
core   +1 more source

A Hands-On Activity to Demonstrate the Central Dogma of Molecular Biology Via a Simulated VDJ Recombination Activity

Journal of Microbiology & Biology Education, 2017
Essential or enduring understandings are often defined as the underlying core concepts or “big ideas” we’d like our students to remember when much of the course content has been forgotten.
Pamela A. Marshall
doaj   +1 more source

Learning a Hybrid Architecture for Sequence Regression and Annotation

, 2015
When learning a hidden Markov model (HMM), sequen- tial observations can often be complemented by real-valued summary response variables generated from the path of hid- den states. Such settings arise in numerous domains, includ- ing many applications in
Carin, Lawrence, Hartemink, Alexander J., Henao, Ricardo, Zhang, Yizhe, Zhong, Jianling   +4 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Rural Education and the teaching of genetics: an investigative didactic possibility

Revista Brasileira de Educação do Campo, 2021
Research related to the genome project, cloning and genetically modified organisms are present inside and outside the school. Such subjects deserve attention in the teaching of genetics due to the difficulties presented by the students, regarding the ...
Kássia Paula Oliveira da Silva, Lenicy Lucas de Miranda Cerqueira, Luciana Melhorança Moreira   +2 more
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Human Chromosome 7: DNA Sequence and Biology [PDF]

Science, 2003
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description, additional structural features such as imprinted genes, fragile sites, and segmental duplications were integrated at the level of the DNA sequence with medical ...
Scherer, Sw, Cheung, J, Macdonald, Jr, Osborne, Lr, Nakabayashi, K, Herbrick, J., Carson, Ar, Parker Katiraee, L, Skaug, J, Khaja, R, Zhang, J, Hudek, Ak, Li, M, Haddad, M, Duggan, Ge, Fernandez, Ba, Kanematsu, E, Gentles, S, Christopoulos, Cc, Choufani, S, Kwasnicka, D, Zheng, Xh, Lai, Z, Nusskern, D, Zhang, Q, Gu, Z, Lu, F, Zeesman, S, Nowaczyk, Mj, Teshima, I, Chitayat, D, Shuman, C, Weksberg, R, Zackai, Eh, Grebe, Ta, Cox, Sr, Kirkpatrick, Sj, Rahman, N, Friedman, Jm, Heng, Hhq, Pelicci, Pg, LO COCO, FRANCESCO, Belloni, E, Shaffer, Lg, Pober, B, Morton, Cc, Gusella, Jf, Bruns, Gap, Korf, Br, Quade, Bj, Ligon, Ah, Ferguson, H, Higgins, Aw, Leach, Nt, Herrick, Sr, Lemyre, E, Farra, Cg, Kim, H., Summers, Am, Gripp, Kw, Roberts, W, Szatmari, P, Winsor, Ejt, Grzeschik, K., Teebi, A, Minassian, Ba, Kere, J, Armengol, L, Pujana, Ma, Estivill, X, Wilson, Md, Koop, Bf, Tosi, S, Moore, Ge, Boright, Ap, Zlotorynski, E, Kerem, B, Kroisel, Pm, Petek, E, Oscier, Dg, Mould, Sj, Dohner, H, Dohner, K, Rommens, Jm, Vincent, Jb, Venter, Jc, Li, Pw, Mural, Rj, Adams, Md, Tsui, L.   +89 more
openaire   +6 more sources

A computational pipeline to visualize DNA-protein binding states using dSMF data

STAR Protocols, 2022
Summary: Here, we present a pipeline to map states of protein-binding DNA in vivo. Our pipeline infers as well as quantifies cooperative binding. Using dual-enzyme single-molecule footprinting (dSMF) data, we show how our workflow identifies binding ...
Satyanarayan Rao, Srinivas Ramachandran
doaj   +1 more source

A topological approach for protein classification

, 2015
Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology.
Cang, Zixuan, Mu, Lin, Opron, Kristopher, Wei, Guo-Wei, Wu, Kedi, Xia, Kelin   +5 more
core   +1 more source