Results 61 to 70 of about 4,078,643 (261)

Hsp-90 and the biology of nematodes [PDF]

, 2009
BACKGROUND: Hsp-90 from the free-living nematode Caenorhabditis elegans is unique in that it fails to bind to the specific Hsp-90 inhibitor, geldanamycin (GA).
Emes, R.D., Gillan, V., Devaney, E., Him, N.A.I.I.N., Maitland, K.   +4 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Nanopore sequencing unveils the complexity of the cold-activated murine brown adipose tissue transcriptome

iScience, 2023
Summary: Alternative transcription increases transcriptome complexity by expression of multiple transcripts per gene. Annotation and quantification of transcripts using short-read sequencing is non-trivial.
Christoph Andreas Engelhard, Sajjad Khani, Sophia Derdak, Martin Bilban, Jan-Wilhelm Kornfeld   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Predicting translation initiation rates for designing synthetic biology

Frontiers in Bioengineering and Biotechnology, 2014
In synthetic biology, precise control over protein expression is required in order to construct functional biological systems. A core principle of the synthetic biology approach is model-guided design and, based on biological understanding of the process,
Benjamin eReeve, Benjamin eReeve, Thomas eHargest, Charlie eGilbert, Tom eEllis, Tom eEllis   +5 more
doaj   +1 more source

DNA methylation protocol for analyzing cell-free DNA in the spent culture medium of human preimplantation embryos

STAR Protocols, 2023
Summary: Cell-free DNA (cfDNA) in spent embryo culture media (SECM) provides prospects for noninvasive preimplantation genetic testing. Here, we present a post-bisulfite-adapter-tagging (PBAT)-based whole-genome DNA methylation sequencing protocol (SECM ...
Yuan Gao, Yidong Chen, Jie Qiao, Jin Huang, Lu Wen   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Impact of the rumen microbiome on milk fatty acid composition of Holstein cattle

Genetics Selection Evolution, 2019
Background Fatty acids (FA) in bovine milk derive through body mobilization, de novo synthesis or from the feed via the blood stream. To be able to digest feedstuff, the cow depends on its rumen microbiome. The relative abundance of the microbes has been
Bart Buitenhuis, Jan Lassen, Samantha Joan Noel, Damian R. Plichta, Peter Sørensen, Gareth F. Difford, Nina A. Poulsen   +6 more
doaj   +1 more source

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. [PDF]

, 2011
BACKGROUND: We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be sequenced.
Wood, Dav, Chew, Keng, Graves, Jennifer A Marshall, Hickford, D., Wang, Jianghui, Shinji Kondo, Margaret B Morgan, Nanette Y Schneider, Nicholas, Frank W., Lara, F, Artem Men, Nazareth, Lynne, Christie L Kovar, Lefevre, CM, Lora R Lewis, Renfree, MB, McColl, KA, Hore, TA, Edson, J, Suzuki, Yutaka, Paul Flicek, Okwuonu, Geoffrey, Flicek, Paul, Pharo, Elizabeth A., Anthony T Papenfuss, Danielle Hickford, Troon, C, Benjamin Lansdell, Wong, Emily S. W., Liu, Y, Kaighin A McColl, Jessica M Stringer, Andrew Cree, Graves, Jennifer A.M., Schneider, NY, Santibanez, J, Herrero, J, Wu, Chen, Liu, Yue, Lewis, Lora, Siddle, Hannah, Hazar-Rethinam, Mehlika, Nicholas, Kevin, Hazar-Rethinam, Mehlike, Fujiyama, Asao, Speed, Terence, Wong, ESW, Richard A Gibbs, Heider, T, Yapa, L, Hsu, Arthur, Wakefield, MJ, Nicholas, K.R., Speed, Terence P., Menzies, Brandon, Delbridge, Margaret L., Schneider, Nanette Y., Jireh Santibanez, Wilson, P, Patel, HR, Gibbs, Richard A, Nishida, Y, Swwong, E, Hongshi Yu, Elizabeth Kuczek, Kuczek, Elizabeth, Troon, Carmen, Sundaravadanam, Yogi, Flicek, P, Fowler, G, Siddle, Hannah V., Cocks, BG, Shoji Tatsumoto, Okwuonu, GO, Papenfuss, AT, Wood, David, Lefèvre, Christophe M., Mohammadi, A, Weinstock, G, Kuroki, Yuko, Deng, Jixin, Tatsumoto, S, et al., Rens, Willem, Deakin, JE, Joshi, V, Frankenberg, Stephen R., Cooper, Desmond, Siddle, HV, Kathryn Beal, Renfree, M. B., James Lindsay, Dinh, HH, Pharo, E.A., Menzies, Brandon R., Yu, HS, Chew, Keng Yih, Forrest, SM, Sugano, Sumio, Kuczek, E, Asao Fujiyama, Wakefield, Matthew J., Annette McGrath, Mohammadi, Amir, Emily SW Wong, John Davis, Graves, JAM, Jing, C, Carmen Troon, Rachel J O'Neill, Hsu, A, Ferguson-Smith, Malcolm, Vandita Joshi, Muzny, Donna M., Lefèvre, Christopher P., Song, Xing-Zhi, Janette Edson, Susan M Forrest, Mandiou, Ion, Frankenberg, SR, Daniel Thomas, Short, Kirsty, Shen, Joshua, Hore, Timothy A., Kuroki, Yoko, Thomas Heider, Shalini N Jhangiani, Hu, Y, Dawn M Carone, Stringer, Jessica, Gerald Fowler, Matthew J Wakefield, Belov, Katherine, Graves, Jennifer A. M., Lewis, Lora R., Nadaf, Shafagh, Pask, Andrew, Yanqiu Hu, Short, Kirsty R., Feng, ZP, Lewis, LR, Song, XZ, Wakefield, Matthew, Waters, P.D., Muzny, Donna, Carone, Dawn M., Malcolm Ferguson-Smith, Wong, ESW ; https://orcid.org/, Wong, Emily S.W., Wilson, Peter, Wu, C, Desmond W Cooper, Nicholas, Frank, McColl, Kaighin A., Jennifer A M Graves, Nazareth, L, Cooper, Desmond W., Nicholas, KR, Cree, Andrew, Yu, H, Muzny, Donna M, Mehlika Hazar-Rethinam, Shen, Joshua Y., Rens, W., Wakefield, M.J., Okwuonu, Geoffrey O., Wong, Emily, Huyen H Dinh, Tanya Levchenko, Cooper, Desmond W, Kuroki, Y, Zenger, K, Yuichiro Nishida, Shaw, G, O'Hara, William, Zenger, KR, Weinstock, George, Pharo, E, Chew, Keng Y., Xing-Zhi Song, McGrath, A, Kovar, Christie, Dinh, Huyen, Waters, Paul D., Shafagh Al Nadaf, Renfree, M.B., Nicholas, FW, Arthur Hsu, Thornton, R, Santibanez, Jireh, Lansdell, Benjamin, Geoff Shaw, Chen, L, Muzny, DM, Chenwei Wang, Kyall R Zenger, O'Neill, Rachel, Elizabeth A Pharo, Wong, E.S.W., San Ruiz, Lefèvre, C.M., Willem Rens, Kovar, Christie L., Yutaka Suzuki, Fremiet Lara, Dinh, Huyen H., Cree, A, Wang, Chenwei, Jixin Deng, Al Nadaf, Shafagh, Graves, Jennifer, Ruiz, San J., Gibbs, RA, William O'Hara, Deakin, J.E., Kondo, Shinji, Renfree, Marilyn B., Cooper, DW, Allison Hall, Kim C Worley, Toyoda, Atsushi, Frankenberg, Stephen, Sugano, S, Timothy A Hore, Brandon R Menzies, Gibbs, Richard A., Chew, KY, Jhangiani, SN, Sumio Sugano, Kovar, CL, Lindsay, James, Hall, Allison, O’Neill, Rachel, Hall, A, Zenger, Kyall R., Stringer, JM, Lewis, Lora R, Christophe M Lefèvre, Searle, Stephen, Janine E Deakin, Short, KR, Wang, C, Wang, J, O'Neill, RJ, Heider, T., Gibbs, Richard, Zenger, K.R., Sarah Williams, Thomas, Daniel, Toyoda, A, Stephen MJ Searle, Morgan, Margaret B, Feng, Z-P, Donna M Muzny, Hannah V Siddle, Williams, S, Zhi-Ping Feng, Morgan, Margaret B., Fairley, S, Levchenko, T, Waters, PD, Davis, J, Shunsuke Suzuki, Hazar-Rethinam, M, Yu, Hongshi, Jing, Chyn, Rebecca Thornton, Amber Stephens, M Graves, Jennifer A., Forrest, Susan M., Chyn Jing, Wood, D, Shaw, G., Pharo, Elizabeth, Kuroki, Y., M Graves, JA, Lei Chen, Shen, JY, Dinh, Huyen H, Jianghui Wang, Chen, Lei, Searle, SMJ, Yoshiyuki Sakaki, Yoko Kuroki, DEAKIN, Janine; id_orcid, Ion Mandiou, Ferguson-Smith, M, Carone, DM, Nicholas, F.W., Deakin, Janine, Joshua Y Shen, Worley, Kim C., Belov, K, Okwuonu, Geoffrey O, Ruiz, SJ, Shen, Joshua Y, Stephens, Amber, McGrath, Annette, Delbridge, ML, Thomas, D, Sakaki, Yoshiyuki, McColl, Kaighin, Searle, Stephen M. J., Hickford, D, Speed, TP, Men, A, Nishida, Yuichiro, Jhangiani, Shalini N, Al Nadaf, S ; https://orcid.org/, Lindsay, J, Papenfuss, Anthony, Tatsumoto, Shoji, Stephens, A, Chen Wu, Ferguson-Smith, M., Men, Artem, Fairley, Susan, Lynne Nazareth, Searle, Stephen M.J., Jhangiani, Shalini, Jhangiani, Shalini N., Susan Fairley, Deakin, Janine E., Davis, John, David Wood, Thornton, Rebecca, Hickford, Danielle, Lansdell, B, Shaw, Geoff, Hu, Yanqiu, Worley, KC, Keng Chew, Joshi, Vandita, Waters, P, Cocks, Benjamin G., Sundaravadanam, Y, Deng, J, Marilyn B Renfree, Nicholas, Kevin R., Pask, Andrew J., Frank W Nicholas, Heider, Thomas, Fujiyama, A, Margaret L Delbridge, Carone, Dawn, Stringer, Jessica M., Rens, W, Kevin R Nicholas, Waters, PD ; https://orcid.org/, Atsushi Toyoda, Wang, C., Fowler, Gerald, Belov, K., Al Nadaf, S, Edson, Janette, Geoffrey O Okwuonu, Hore, Timothy, Papenfuss, A.T., Andrew J Pask, Levchenko, Tanya, Renfree, Marilyn, Schneider, Nanette, Lindsay, J., Kirsty R Short, Pharo, EA, Herrero, Javier, O'Hara, W, Zenger, Kyall, Kovar, Christie L, Forrest, Susan, Terence P Speed, Pask, AJ, Ruiz, San, Benjamin G Cocks, Paul D Waters, Lefevre, Christophe, Suzuki, Y, Suzuki, S, Yapa, Lankesha, Beal, Kathryn, George Weinstock, Amir Mohammadi, Stephen R Frankenberg, Wang, CW, Menzies, BR, Morgan, MB, Worley, Kim, Lara, Fremiet, Speed, Terence P, Katherine Belov, Waters, Paul, Papenfuss, Anthony T., Feng, Zhi-Ping, Peter Wilson, Suzuki, Shunsuke, O'Neill, Rachel J., Yue Liu, Sakaki, Y, Delbridge, Margaret, Yogi Sundaravadanam, Williams, Sarah, Fowler, Gerard, Song, X-Z, Javier Herrero, Mandiou, I, Cocks, Benjamin, Lankesha Yapa, Beal, K, Morgan, Margaret, Lefevre, Christopher M., Kondo, S   +410 more
core   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source