Results 21 to 30 of about 4,078,643 (261)

Getting to the root of plant biology: impact of the Arabidopsis genome sequence on root research [PDF]

, 2010
Prior to the availability of the genome sequence, the root of Arabidopsis had attracted a small but ardent group of researchers drawn to its accessibility and developmental simplicity.
Schiefelbein, John W., Bennett, Malcolm, Benfey, Philip N.   +2 more
core   +1 more source

Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells

Stem Cell Research, 2014
The shortage of molecular information on cell cycle changes along embryonic stem cell (ESC) differentiation prompts an in silico approach, which may provide a novel way to identify candidate genes or mechanisms acting in coordinating the two programs. We
Angela Re, Christopher T. Workman, Levi Waldron, Alessandro Quattrone, Søren Brunak   +4 more
doaj   +1 more source

Genome Evolution of Wolbachia Strain wPip from the Culex pipiens Group [PDF]

, 2008
The obligate intracellular bacterium Wolbachia pipientis strain wPip induces cytoplasmic incompatibility (CI), patterns of crossing sterility, in the Culex pipiens group of mosquitoes.
Sinkins, Steven P., Sanders, Mandy J, Walker, T, Sebaihia, M., Quail, M. A., Quail, MA, Quail, Michael A., Sanders, MJ, Sebaihia, M, Parkhill, J, Thomson, N., Lord, Angela, Sanders, Susanne, Klasson, L, Sanders, Mandy J., Parkhill, J., Klasson, Lisa, Lord, A., Sanders, S, Klasson, L., Sinkins, Steven P, Lord, A, Sinkins, S. P., O'Neill, Scott L, Thomson, N, Quail, Michael A, Sebaihia, Mohammed, O'Neill, S. L., Parkhill, Julian, Earl, J, Sanders, S., Walker, Thomas, Thomson, Nicholas, O'Neill, Scott L., Earl, J., O'Neill, SL, Earl, Julie, Walker, T., Sinkins, SP, Sanders, M. J.   +39 more
core   +1 more source

Quantification of within-sample genetic heterogeneity from SNP-array data

Scientific Reports, 2017
Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement.
Pierre Martinez, Christopher Kimberley, Nicolai J. BirkBak, Andrea Marquard, Zoltan Szallasi, Trevor A. Graham   +5 more
doaj   +1 more source

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis [PDF]

, 2009
Background Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland ...
Andy Barron, Maskell, Duncan, Field, TR, Leigh, James A., Nicola Lennard, Quail, MA, Clark, L, Parkhill, J, Egan, Sharon A., Bignell, A, Bentley, Stephen D., Holden, Matthew T. G., Terence R Field, Clark, Louise, Lennard, Nicola, Philip N Ward, Whatmore, AM, Ward, Philip N., Matthew TG Holden, Dowson, Christopher G., Adrian M Whatmore, Sharon A Egan, Barrell, BG, Bart G Barrell, Whatmore, Adrian M., Barron, Andy, Holden, MTG, Kehoe, M, Egan, SA, Neil Chanter, Bentley, SD, Quail, Michael A., Alexandra Bignell, Stephen D Bentley, Chanter, Neil, Louise Clark, Leigh, JA, Barron, A, Julian Parkhill, Woodward, J, Barrell, Bart G., Woodward, John, Bignell, Alexandra, Michael A Quail, Parkhill, Julian, James A Leigh, Dowson, CG, Christopher G Dowson, Ward, PN, Chanter, N, Duncan Maskell, Maskell, D, Michael Kehoe, John Woodward, Lennard, N, Kehoe, Michael, Field, Terence R.   +56 more
core   +5 more sources

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius) [PDF]

, 2010
Background The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies.
Finlay Emma K., Park Stephen D. E., Daniel G Bradley, Shapiro Beth, Edwards Ceiridwen J., Ceiridwen J Edwards, Murphy, A., MacHugh David E., Beth Shapiro, Edwards, C.J., Bradley Daniel G., Park, S.D.E., MacHugh, D.E., McGettigan, Paul A., Shapiro, Beth, Alison Murphy, Martin B Richards, Chamberlain Andrew T., Loftus Brendan J., Murphy, Alison, Bradley, D.G., Knapp, Michael, David A Magee, Amanda J Lohan, Magee David A., Stephen D E Park, Lohan, A.J., Shapiro, B., Magee, David A., Bradley, Daniel G., Brendan J Loftus, Richards Martin B., Richards, M.B., Paul A McGettigan, Loftus, Brendan J., Park, Stephen D E, David E MacHugh, Chamberlain, Andrew T., Murphy Alison, MacHugh, David E., Andrew T Chamberlain, Park, Stephen D. E., Lohan, Amanda J., Lohan Amanda J., Loftus, B.J., Finlay, Emma K., McGettigan, P.A., Finlay, E.K., Richards, Martin B., Magee, D.A., Emma K Finlay, McGettigan Paul A., Chamberlain, A.T., Edwards, Ceiridwen J.   +53 more
core   +1 more source

Is the pan-genome also a pan-selectome? [v1; ref status: indexed, http://f1000r.es/Vl9wKI]

F1000Research, 2012
The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the ‘flexible’ regions).
Francisco Rodriguez-Valera, David W Ussery   +1 more
doaj   +1 more source

Mechanisms of gene duplication and translocation and progress towards understanding their relative contributions to animal genome evolution [PDF]

, 2012
Duplication of genetic material is clearly a major route to genetic change, with consequences for both evolution and disease. A variety of forms and mechanisms of duplication are recognised, operating across the scales of a few base pairs upto entire ...
Mendivil Ramos, Olivia, Ferrier, David Ellard Keith   +1 more
core   +1 more source

Dissecting spatio‐temporal protein networks driving human heart development and related disorders

Molecular Systems Biology, 2010
Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems‐level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting
Kasper Lage, Kjeld Møllgård, Steven Greenway, Hiroko Wakimoto, Joshua M Gorham, Christopher T Workman, Eske Bendsen, Niclas T Hansen, Olga Rigina, Francisco S Roque, Cornelia Wiese, Vincent M Christoffels, Amy E Roberts, Leslie B Smoot, William T Pu, Patricia K Donahoe, Niels Tommerup, Søren Brunak, Christine E Seidman, Jonathan G Seidman, Lars A Larsen   +20 more
doaj   +1 more source

ANALYZING THE GENOMIC VARIATION OF MICROBIAL CELL FACTORIES IN THE ERA OF “NEW BIOTECHNOLOGY”

Computational and Structural Biotechnology Journal, 2012
The application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular,
Markus Herrgård, Gianni Panagiotou
doaj   +1 more source