prot4EST: translating expressed sequence tags from neglected genomes [PDF]
, 2004 The genomes of an increasing number of species are being investigated through generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing errors and typically define incomplete transcripts, making downstream annotation difficult ...
Mark L Blaxter +3 more
core +1 more source
Quantification of within-sample genetic heterogeneity from SNP-array data
Scientific Reports, 2017 Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement.
Pierre Martinez +5 more
doaj +1 more source
A Molecular Biology Database Digest [PDF]
, 2000 Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18].
Kröger, Peer +3 more
core +1 more source
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
Molecular Systems Biology, 2011 Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a bottleneck in some analysis pipelines when faced with data sets
Fabian Sievers +11 more
semanticscholar +1 more source
So what do we really mean when we say that systems biology is holistic? [PDF]
, 2010 Background: An old debate has undergone a resurgence in systems biology: that of reductionism versus holism. At least 35 articles in the systems biology literature since 2003 have touched on this issue.
Gatherer, Derek, Derek Gatherer
core +1 more source
Detecting sequence signals in targeting peptides using deep learning
Life Science Alliance, 2019 During the development of TargetP 2.0, a state-of-the-art method to predict targeting signal, we find a previously overlooked biological signal for subcellular targeting using the output from a deep learning method.
J. J. Almagro Armenteros +6 more
semanticscholar +1 more source
Is the pan-genome also a pan-selectome? [v1; ref status: indexed, http://f1000r.es/Vl9wKI]
F1000Research, 2012 The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the ‘flexible’ regions).
Francisco Rodriguez-Valera +1 more
doaj +1 more source
Dissecting spatio‐temporal protein networks driving human heart development and related disorders
Molecular Systems Biology, 2010 Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems‐level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting
Kasper Lage +20 more
doaj +1 more source
ANALYZING THE GENOMIC VARIATION OF MICROBIAL CELL FACTORIES IN THE ERA OF “NEW BIOTECHNOLOGY”
Computational and Structural Biotechnology Journal, 2012 The application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular,
Markus Herrgård, Gianni Panagiotou
doaj +1 more source
The Genome Sequence of Taurine Cattle: A window to ruminant biology and evolution
Science, 2009 A survey of genetic diversity of cattle suggests two domestication events in Asia and selection by husbandry. Not Just Dinner on Legs Several thousand years ago, human beings realized the virtues of domesticating wild animals as easy meat.
C. Elsik, R. Tellam, K. Worley
semanticscholar +1 more source