Results 21 to 30 of about 5,771,427 (358)
Impact of Nucleic Acid Sequencing on Viroid Biology [PDF]
International Journal of Molecular Sciences, 2020 The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis technique.
Charith Raj Adkar-Purushothama +1 more
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Neuropathology, 2011 One of the challenges in neuropathology is to clarify how molecules, functional carriers of uni-dimensional sequence of amino acid or nucleic acid, behave to engender disease-specific pathological processes in complex three-dimensional (3D) structures such as the human brain in an ordered chronological sequence (four-dimensional extension as a whole ...
T. Uchihara
semanticscholar +4 more sources
Structural biology of metal-binding sequences
Current Opinion in Chemical Biology, 2002 NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and ...
Stanley J. Opella +2 more
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Sequence Alignment in Molecular Biology
Journal of Computational Biology, 1998 Molecular biology is becoming a computationally intense realm of contemporary science and faces some of the current grand scientific challenges. In its context, tools that identify, store, compare and analyze effectively large and growing numbers of bio-sequences are found of increasingly crucial importance.
Apostolico, Alberto, Fiancarlo, Raffaele
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SaPt-CNN-LSTM-AR-EA: a hybrid ensemble learning framework for time series-based multivariate DNA sequence prediction [PDF]
PeerJ, 2023 Biological sequence data mining is hot spot in bioinformatics. A biological sequence can be regarded as a set of characters. Time series is similar to biological sequences in terms of both representation and mechanism.
Wu Yan +5 more
doaj +2 more sources
Flexible RNA design under structure and sequence constraints using formal languages [PDF]
, 2013 The problem of RNA secondary structure design (also called inverse folding) is the following: given a target secondary structure, one aims to create a sequence that folds into, or is compatible with, a given structure.
Denise, Alain +5 more
core +5 more sources
What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?
Viruses, 2015 Phage therapy, a practice widespread in Eastern Europe, has untapped potential in the combat against antibiotic-resistant bacterial infections. However, technology transfer to Western medicine is proving challenging. Bioinformatics analysis could help to
Henrike Zschach +11 more
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Rapid Nickel-based Isolation of Extracellular Vesicles from Different Biological Fluids
Bio-Protocol, 2020 Extracellular vesicles (EVs) are membranous structures that cells massively release in extracellular fluids. EVs are cargo of cellular components such as lipids, proteins, and nucleic acids that can work as a formidable source in liquid biopsy studies ...
Michela Notarangelo +8 more
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Genomics and proteomics: a signal processor's tour [PDF]
, 2004 The theory and methods of signal processing are becoming increasingly important in molecular biology. Digital filtering techniques, transform domain methods, and Markov models have played important roles in gene identification, biological sequence ...
Vaidyanathan, P. P.
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DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets.
Molecular biology and evolution, 2017 We present version 6 of the DNA Sequence Polymorphism (DnaSP) software, a new version of the popular tool for performing exhaustive population genetic analyses on multiple sequence alignments.
J. Rozas +6 more
semanticscholar +1 more source