Results 21 to 30 of about 2,264,396 (196)
iScience, 2021 Summary: Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage)
André Azevedo Reis Teixeira +16 more
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The Multiple Sequence Alignment Problem in Biology [PDF]
SIAM Journal on Applied Mathematics, 1988 Summary: The study and comparison of sequences of characters from a finite alphabet is relevant to various areas of science, notably molecular biology. The measurement of sequence similarity involves the consideration of the different possible sequence alignments in order to find an optimal one for which the ``distance'' between sequences is minimum ...
Carrillo, Humberto, Lipman, David
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STAR Protocols, 2023 Summary: This protocol demonstrates how a fragmented reference genome and low-coverage sequencing data can be efficiently utilized for population genetic analyses of a species with highly reduced genetic diversity.
Emmi Olkkonen, Ari Löytynoja
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Developing and applying heterogeneous phylogenetic models with XRate [PDF]
, 2012 Modeling sequence evolution on phylogenetic trees is a useful technique in computational biology. Especially powerful are models which take account of the heterogeneous nature of sequence evolution according to the "grammar" of the encoded gene features.
A Heger +32 more
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Towards an Encyclopaedia of Sequence Biology [PDF]
Linguistic Frontiers, 2018 Abstract In this review, I have presented several topics relevant to the present state and to the future state of the scientific field that I propose to call sequence biology (SB). In some pertinent publications, this field was called DNA linguistics. At the heart of SB lies a concept of a sequence code.
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Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells
Stem Cell Research, 2014 The shortage of molecular information on cell cycle changes along embryonic stem cell (ESC) differentiation prompts an in silico approach, which may provide a novel way to identify candidate genes or mechanisms acting in coordinating the two programs. We
Angela Re +4 more
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Quantification of within-sample genetic heterogeneity from SNP-array data
Scientific Reports, 2017 Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement.
Pierre Martinez +5 more
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High‐throughput sequencing for biology and medicine
Molecular Systems Biology, 2013 Advances in genome sequencing have progressed at a rapid pace, with increased throughput accompanied by plunging costs. But these advances go far beyond faster and cheaper. High‐throughput sequencing technologies are now routinely being applied to a wide range of important topics in biology and medicine, often allowing researchers to address important ...
Wendy Weijia Soon +2 more
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Is the pan-genome also a pan-selectome? [v1; ref status: indexed, http://f1000r.es/Vl9wKI]
F1000Research, 2012 The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the ‘flexible’ regions).
Francisco Rodriguez-Valera +1 more
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Bioinformatics Databases: State of the Art and Research Perspectives [PDF]
, 2003 Bioinformatics or computational biology, i.e. the application of mathematical and computer science methods to solving problems in molecular biology that require large scale data, computation, and analysis, is a research area currently receiving a ...
Bry, François, Kröger, Peer
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