Results 21 to 30 of about 4,751,605 (346)
Neuropathology, 2011 One of the challenges in neuropathology is to clarify how molecules, functional carriers of uni-dimensional sequence of amino acid or nucleic acid, behave to engender disease-specific pathological processes in complex three-dimensional (3D) structures such as the human brain in an ordered chronological sequence (four-dimensional extension as a whole ...
T. Uchihara
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Sequence Alignment in Molecular Biology
Journal of Computational Biology, 1998 Molecular biology is becoming a computationally intense realm of contemporary science and faces some of the current grand scientific challenges. In its context, tools that identify, store, compare and analyze effectively large and growing numbers of bio-sequences are found of increasingly crucial importance.
Apostolico, Alberto, Fiancarlo, Raffaele
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Structural biology of metal-binding sequences
Current Opinion in Chemical Biology, 2002 NMR spectroscopy and X-ray crystallography in conjunction with extended X-ray absorption fine structure spectroscopy, have contributed to the elucidation of the structural biology of protein-mediated mechanisms of heavy metal homeostasis. Among the most striking aspects of these investigations are the remarkable similarity of metal-ion-transport and ...
Stanley J. Opella +2 more
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Impact of Nucleic Acid Sequencing on Viroid Biology [PDF]
International Journal of Molecular Sciences, 2020 The early 1970s marked two breakthroughs in the field of biology: (i) The development of nucleotide sequencing technology; and, (ii) the discovery of the viroids. The first DNA sequences were obtained by two-dimensional chromatography which was later replaced by sequencing using electrophoresis technique.
Charith Raj Adkar-Purushothama +1 more
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Localization of T cell clonotypes using the Visium spatial transcriptomics platform
STAR Protocols, 2022 Summary: We present a protocol to localize T cell receptor clones using the Visium spatial transcriptomics platform. This approach permits simultaneous localization of both gene expression and T cell clonotypes in situ within tissue sections.
William H. Hudson, Lisa J. Sudmeier
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RBPSpot: Learning on appropriate contextual information for RBP binding sites discovery
iScience, 2021 Summary: Identifying the factors determining the RBP-RNA interactions remains a big challenge. It involves sparse binding motifs and a suitable sequence context for binding. The present work describes an approach to detect RBP binding sites in RNAs using
Nitesh Kumar Sharma +5 more
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What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?
Viruses, 2015 Phage therapy, a practice widespread in Eastern Europe, has untapped potential in the combat against antibiotic-resistant bacterial infections. However, technology transfer to Western medicine is proving challenging. Bioinformatics analysis could help to
Henrike Zschach +11 more
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iScience, 2021 Summary: Large-scale mapping of antigens and epitopes is pivotal for developing immunotherapies but challenging, especially for eukaryotic pathogens, owing to their large genomes. Here, we developed an integrated platform for genome phage display (gPhage)
André Azevedo Reis Teixeira +16 more
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Rapid Nickel-based Isolation of Extracellular Vesicles from Different Biological Fluids
Bio-Protocol, 2020 Extracellular vesicles (EVs) are membranous structures that cells massively release in extracellular fluids. EVs are cargo of cellular components such as lipids, proteins, and nucleic acids that can work as a formidable source in liquid biopsy studies ...
Michela Notarangelo +8 more
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STAR Protocols, 2023 Summary: This protocol demonstrates how a fragmented reference genome and low-coverage sequencing data can be efficiently utilized for population genetic analyses of a species with highly reduced genetic diversity.
Emmi Olkkonen, Ari Löytynoja
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