Results 71 to 80 of about 5,758,485 (356)
Synthetic biology open language (SBOL) version 3.0.0
Journal of Integrative Bioinformatics, 2020 Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems.
Baig Hasan +14 more
doaj +1 more source
A two-base encoded DNA sequence alignment problem in computational biology [PDF]
, 2009 The recent introduction of instruments capable of producing millions of DNA sequence reads in a single run is rapidly changing the landscape of genetics.
Chang, Jen-Mei +12 more
core
Phase transition in the sample complexity of likelihood-based phylogeny inference [PDF]
, 2017 Reconstructing evolutionary trees from molecular sequence data is a fundamental problem in computational biology. Stochastic models of sequence evolution are closely related to spin systems that have been extensively studied in statistical physics and ...
Roch, Sebastien, Sly, Allan
core +1 more source
Single-cell sequencing in stem cell biology
Genome Biology, 2016 Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem cell populations, but these differences are masked when bulk cells are used for omic analysis. Single-cell sequencing technologies serve as powerful tools to dissect cellular heterogeneity comprehensively and to identify distinct phenotypic cell types, even ...
Lu Wen, Fuchou Tang
openaire +3 more sources
Skin microbiota in health and disease: From sequencing to biology [PDF]
The Journal of Dermatology, 2020 AbstractMicrobiota live in a closely regulated interaction with their environment, and vice versa. The presence and absence of microbial entities is greatly influenced by features of the niche in which they thrive. Characteristic of this phenomenon is that different human skin sites harbor niche‐specific communities of microbes.
Ederveen, T.H.A. +7 more
openaire +5 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Are there laws of genome evolution? [PDF]
, 2011 Research in quantitative evolutionary genomics and systems biology led to the discovery of several universal regularities connecting genomic and molecular phenomic variables.
Koonin, Eugene V.
core +4 more sources
Surprising biology in uncharted microbial sequences
, 2023 The microbiome, all microorganisms in their natural habitat, can be collected on filters and its DNA extracted. Sequencing of this metagenome allows us to observe microorganisms not under a microscope or in the lab but via their DNA and in their natural habitat, revealing who they are and what they can do.
openaire +3 more sources
Chemical Society Reviews, 2014 Improving enzymes by directed evolution requires the navigation of very large search spaces; we survey how to do this intelligently.
A. Currin +3 more
semanticscholar +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source