Results 111 to 120 of about 4,125,791 (291)

FlatProt: 2D visualization eases protein structure comparison

BMC Bioinformatics
Background Understanding and comparing three-dimensional (3D) structures of proteins can advance bioinformatics, molecular biology, and drug discovery.
Tobias Olenyi, Constantin Carl, Tobias Senoner, Ivan Koludarov, Burkhard Rost   +4 more
doaj   +1 more source

Seedability: optimizing alignment parameters for sensitive sequence comparison. [PDF]

Bioinform Adv, 2023
Ayad LAK, Chikhi R, Pissis SP.
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Genomic sequencing and analyses of HearMNPV—a new Multinucleocapsid nucleopolyhedrovirus isolated from Helicoverpa armigera

Virology Journal, 2012
Background HearMNPV, a nucleopolyhedrovirus (NPV), which infects the cotton bollworm, Helicoverpa armigera, comprises multiple rod-shaped nucleocapsids in virion(as detected by electron microscopy).
Tang Ping, Zhang Huan, Li Yinü, Han Bin, Wang Guozeng, Qin Qilian, Zhang Zhifang   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Identification of a zucchini yellow mosaic virus infecting squash in Hangzhou

浙江大学学报. 农业与生命科学版, 2003
A filamentous virus was isolated from naturally infected squash (Cucuribita moschata L.), showing yellow mosaic in Hangzhou, Zhejiang Province, in autumn 1999. This virus was found to cause systemic symptoms on all the Cucuribitaceae plants tested.
CHEN Jie-yun, CHAI Li-hong, CHEN Ji-shuang, HONG Jian   +3 more
doaj   +1 more source

Fast and robust metagenomic sequence comparison through sparse chaining with skani. [PDF]

Nat Methods, 2023
Shaw J, Yu YW.
europepmc   +1 more source

Exploring deep phylogenies using protein structure : a dissertation submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry, Institute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand [PDF]

, 2018
Recent times have seen an exponential growth in protein sequence and structure data. The most popular way of characterising newly determined protein sequences is to compare them to well characterised sequences and predict the function of novel sequences ...
Malik, Ashar J
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source