Results 61 to 70 of about 631,057 (304)

Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays

BMC Biology, 2023
Background The radiation of mammals at the extinction of the dinosaurs produced a plethora of new forms—as diverse as bats, dolphins, and elephants—in only 10–20 million years.
Margarita V. Brovkina, Margaret A. Chapman, Matthew L. Holding, E. Josephine Clowney   +3 more
doaj   +1 more source

TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Giraud-Panis, Marie-Josèphe, Marie-Josèphe Giraud-Panis, Giraud-Panis Marie-Josèphe, Giraud-Panis, M.J., Maria Savino (169324), Pinte, Sébastien, Maria Savino, Eric Gilson (139222), Colasanti, Valentina, Bauwens, Serge, Valentina Colasanti (169302), Pusch, Miriam Caroline, Stefano Cacchione, Bauwens Serge, Frédérique Magdinier (169297), Colasanti Valentina, Pinte Sébastien, Magdinier, Frédérique, Miriam Caroline Pusch, Gilson, Eric, Alessandra Galati, Pusch Miriam Caroline, Savino Maria, Ruggero Ricordy (169313), Gilson Eric, Serge Bauwens, M. J. Giraud Panis, Cacchione Stefano, Stefano Cacchione (169328), Magdinier Frédérique, Ruggero Ricordy, Eric Gilson, Frederique Magdinier, Sébastien Pinte (169308), Galati, Alessandra, Cacchione, Stefano, Sebastien Pinte, Marie-Josèphe Giraud-Panis (169317), Galati Alessandra, Savino, Maria, Miriam Caroline Pusch (169321), Valentina Colasanti, Ricordy, Ruggero, Ricordy Ruggero, Alessandra Galati (169293), Serge Bauwens (169304)   +45 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The mitochondrial genome of Cavia aperea

Mitochondrial DNA. Part B. Resources, 2020
Cavia aperea is a wild guinea pig found throughout South America. The previously published mitochondrial sequence for C. aperea was highly divergent from the C. porcellus sequence and contained stop codons within open reading frames.
Azizia Wahedi, Anja Günther, Alexandra Weyrich, Neal Sondheimer   +3 more
doaj   +1 more source

Sequence and domain organization of UvrD.

, 2014
A. The detailed domain organization of P. falciparum UvrD helicase. The conserved sequences of each domain are written inside the boxes. The text in blue refers to the names of various conserved domains and the numbers refer to the amino acids separating
Abulaish Ansari (118023), Renu Tuteja (27601), Mohammed Tarique (118026)   +2 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes [PDF]

, 2009
Background: The Cronobacter genus (Enterobacter sakazakii) has come to prominence due to its association with infant infections, and the ingestion of contaminated reconstituted infant formula. C. sakazakii and C.
Loughlin, Michael, Dr., Manning, Georgina, Caubilla-Barron, J, Kucerova, E, Forsythe, S. J. (Steve J.), Manning Georgina, Dowson, Christopher G., Loughlin Michael, Dowson, CG, Forsythe, S, Loughlin, M, Kucerova, Eva, Caubilla-Barron Juncal, Forsythe Stephen, Baldwin Adam, Kucerova Eva, Baldwin, Adam, Caubilla-Barron, Juncal, Dowson Christopher, Manning, G, Baldwin, A   +20 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ISPst9, an ISL3-like insertion sequence from Pseudomonas stutzeri AN10 involved in catabolic gene inactivation [PDF]

, 2008
A novel insertion sequence (IS), ISPst9, from Pseudomonas stutzeri AN10 was cloned and characterized. ISPst9 is a typical bacterial IS, consisting of a 2472-bp element flanked by 24-bp perfect inverted repeats that generates 8-bp AT-rich target ...
Martín-Cardona, Cèlia, Christie-Oleza, Joseph A., Lalucat, Jorge, Christie-Oleza, Joseph Alexander, Bosch, Rafael, Nogales, Balbina, Lanfranconi, Mariana P., Albertí, Sebastián   +7 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source