Results 71 to 80 of about 631,057 (304)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Evolutionary innovations and the organization of protein functions in genotype space. [PDF]
PLoS ONE, 2010 The organization of protein structures in protein genotype space is well studied. The same does not hold for protein functions, whose organization is important to understand how novel protein functions can arise through blind evolutionary searches of ...
Evandro Ferrada, Andreas Wagner
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2017 In this study, we firstly obtained the complete mitochondrial genome DNA sequence of the Ambassis gymnocephalus. Its length is 17,388 bp, containing 13 protein-coding genes, 2 rRNAs, 22 tRNAs and a large noncoding region.
Yao Dong +6 more
doaj +1 more source
, 2002 The complete nucleotide sequence of the genomic RNA of an aphid-infecting virus, Aphid lethal paralysis virus (ALPV), has been determined. The genome is 9812 nt in length and contains two long open reading frames (ORFs), which are separated by an ...
Dullemans, A.M. +5 more
core
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
, 1991 Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J. +4 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Neurons and networks organizing and sequencing memories
Brain Research, 2015 Hippocampal CA1 and CA3 neurons sampled randomly in large numbers in primate brain show conclusive examples of hierarchical encoding of task specific information. Hierarchical encoding allows multi-task utilization of the same hippocampal neural networks via distributed firing between neurons that respond to subsets, attributes or "categories" of ...
Deadwyler, Sam A. +4 more
openaire +2 more sources
, 2002 The complete nucleotide sequence of an ophiovirus associated with lettuce big-vein disease has been elucidated. The genome consisted of four RNA molecules of approximately 7ò8, 1ò7, 1ò5 and 1ò4 kb.
Wilk, F., van der +3 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source