Results 71 to 80 of about 2,885,310 (330)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Van der Waerden spaces and Hindman spaces are not the same
, 2001 A Hausdorff topological space X is van der Waerden if for every sequence (x_n)_n in X there is a converging subsequence (x_n)_{n in A} where subset A of omega contains arithmetic progressions of all finite lengths.
Kojman, Menachem, Shelah, Saharon
core +1 more source
Relation of Morrey Sequence Spaces, Weak Type Morrey Sequence Spaces, and Sequence Spaces
Jurnal Matematika MANTIK, 2022 Pragasto Aji Hendro Puadi +2 more
openaire +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
On the Domain of the Pell-Lucas Matrix in the Spaces c and c_0
Dera Natung Government College Research JournalIn this study, we introduce new Banach sequence spaces $c(\Theta), c_0(\Theta)$, defined via a regular infinite matrix $ \Theta = (\lambda_{nk})$, where \[ \Theta_{nk} = \begin{cases} \dfrac{2\lambda_k}{3\lambda_n+\lambda_{n-1}} & 0 \leq k \leq n ...
Shiva Shah
doaj +1 more source
Sampling expansions associated with quaternion difference equations
, 2020 Starting with a quaternion difference equation with boundary conditions, a parameterized sequence which is complete in finite dimensional quaternion Hilbert space is derived. By employing the parameterized sequence as the kernel of discrete transform, we
Cheng, Dong +3 more
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Decoding RNA-Protein interactions using high-throughput methods
RNA BiologyRNA-binding proteins (RBPs) constitute a diverse class of proteins essential for every stage of gene expression process. Many RBPs are also linked to human diseases and pathologies.
Marianne Régis +2 more
doaj +1 more source