Results 161 to 170 of about 3,761,412 (291)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Molecular epidemiology of rodent-borne <i>Leptospira</i> spp. in Sri Lanka: identification of novel sequence types and previously unrecognized reservoir animals. [PDF]

J Med Microbiol
Rathnayake N, Takabe K, Muthusinghe D, Vijeyakumaran R, Senarathne P, Dissanayake N, Urata S, Yoshimatsu K, Akeda Y, Gamage C, Koizumi N.   +10 more
europepmc   +1 more source

Anti-biofilm Activity of Human Milk Oligosaccharides in Clinical Strains of Streptococcus agalactiae with Diverse Capsular and Sequence Types. [PDF]

Chembiochem, 2023
Moore RE, Spicer SK, Talbert JA, Manning SD, Townsend SD, Gaddy JA.   +5 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

<i>Neisseria gonorrhoeae</i> Sequence Types During an Increase of Gonorrhea Among Young Women in 2022 and 2023 in the Netherlands. [PDF]

Open Forum Infect Dis
Visser M, Zondag HCA, van Benthem BHB, Klaassen CHW, Bruisten SM, Twisk DE, van Veen SQ, de Vries HJC, Wolffs PFG, van Dam AP.   +9 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Hemotropic <i>Mycoplasma</i> in cattle and Asian water buffalo in Thailand: Revealing globally distributed sequence types and regional genetic diversity. [PDF]

Curr Res Parasitol Vector Borne Dis
Arnuphapprasert A, Nugraheni YR, Kaewthamasorn M.   +2 more
europepmc   +1 more source

Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock. [PDF]

Sci Rep, 2023
El Zowalaty ME, Lamichhane B, Falgenhauer L, Mowlaboccus S, Zishiri OT, Forsythe S, Helmy YA.   +6 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Distribution of Carbapenemase Genes Associated With Global High-Risk Sequence Types in Pseudomonas aeruginosa Isolates From Chronic Leg Ulcer Patients in Northern Tanzania. [PDF]

Int Wound J
Sengeruan LP, Omar OS, Kanje LE, Kimu P, Wadugu B, van Zwetselaar M, Kumburu H, Sonda T, Chugulu S, Mshana J.   +9 more
europepmc   +1 more source