Results 181 to 190 of about 1,508,662 (316)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Listeria monocytogenes of two sequence types in a maternal-fetal listeriosis: clinical management and bacterial genomics. [PDF]

BMC Infect Dis
Liu Z, Wang Y, Wang C, Liu L, Li X, Li G, Wei H, Li Z, Zhao J, Zhang J.   +9 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pathogenic diversity of <i>Klebsiella pneumoniae</i> strains with different serotypes and sequence types from human liver abscess. [PDF]

Front Microbiol
Ren X, Liu X, Chen Y, Su A, Du B, Zhao H, Feng Y, Xue G, Cui J, Ke Y, Gan L, Feng J, Fan Z, Fu T, Xu Z, Yu Z, Yang Y, Zhang T, Huang L, Yan C, Yuan J.   +20 more
europepmc   +1 more source

Insights into the Intersection of Biocide Resistance, Efflux Pumps, and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii: A Multicenter Study. [PDF]

Pathogens, 2023
Taj Z, Rasool MH, Khurshid M, Aslam B, Qamar MU.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Turyn type sequences

, 2019
In this paper we study the so called Turyn type sequences and some heuristics algorithms to generate them. The importance of these sequences lies, at least, in the fact that they can be used to construct some Hadamard matrices of order 4(3m - 1), where m is the length of the Turyn type sequence through the theorem of Goethals-Seidal.
Segura Ugalde, Esteban, Piza Volio, Eduardo   +1 more
openaire   +1 more source

Genotyping of Acinetobacter baumannii clinical isolates from Polish hospitals uncovers novel sequence types. [PDF]

Sci Rep
Sidor-Dzitkowska K, Marszalik A, Kraśnicka A, Zalewska M, Wróblewska M, Bakuła Z, Popowska M, Bogusławska J, Skirecki T, Jagielski T, Stachowiak R.   +10 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

<i>Neisseria gonorrhoeae</i> Sequence Types During an Increase of Gonorrhea Among Young Women in 2022 and 2023 in the Netherlands. [PDF]

Open Forum Infect Dis
Visser M, Zondag HCA, van Benthem BHB, Klaassen CHW, Bruisten SM, Twisk DE, van Veen SQ, de Vries HJC, Wolffs PFG, van Dam AP.   +9 more
europepmc   +1 more source