Results 181 to 190 of about 7,026,554 (307)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids. [PDF]

Zoonoses Public Health
Garcias B, Seminati C, Kobras CM, Sheppard SK, Molina-López RA, Darwich L.   +5 more
europepmc   +1 more source

Insights into the Intersection of Biocide Resistance, Efflux Pumps, and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii: A Multicenter Study. [PDF]

Pathogens, 2023
Taj Z, Rasool MH, Khurshid M, Aslam B, Qamar MU.   +4 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pathogenic diversity of <i>Klebsiella pneumoniae</i> strains with different serotypes and sequence types from human liver abscess. [PDF]

Front Microbiol
Ren X, Liu X, Chen Y, Su A, Du B, Zhao H, Feng Y, Xue G, Cui J, Ke Y, Gan L, Feng J, Fan Z, Fu T, Xu Z, Yu Z, Yang Y, Zhang T, Huang L, Yan C, Yuan J.   +20 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A cross-cohort description of young people's housing experience in Britain over 30 years: An application of Sequence Analysis [PDF]

Methods. Sequence Analysis supported by Event History Analysis. Key Findings. Despite only 12 years separating both cohorts, the younger 1970 cohort exhibited very different patterns of housing including a slower progression out of the parental home and ...
Dylan Kneale, Richard D Wiggins, Ruth Lupton, Polina Obolenskaya   +3 more
core  

Genotyping of Acinetobacter baumannii clinical isolates from Polish hospitals uncovers novel sequence types. [PDF]

Sci Rep
Sidor-Dzitkowska K, Marszalik A, Kraśnicka A, Zalewska M, Wróblewska M, Bakuła Z, Popowska M, Bogusławska J, Skirecki T, Jagielski T, Stachowiak R.   +10 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

<i>Neisseria gonorrhoeae</i> Sequence Types During an Increase of Gonorrhea Among Young Women in 2022 and 2023 in the Netherlands. [PDF]

Open Forum Infect Dis
Visser M, Zondag HCA, van Benthem BHB, Klaassen CHW, Bruisten SM, Twisk DE, van Veen SQ, de Vries HJC, Wolffs PFG, van Dam AP.   +9 more
europepmc   +1 more source