Results 171 to 180 of about 3,761,412 (291)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Quantitative Confounder Analysis of Electrocardiogram Signals in Cardiac Magnetic Resonance at 1.5, 3 and 7 T-Assessing Standardized Electrode Positions and Sequence Types-Towards Quality Assurance. [PDF]

J Magn Reson Imaging
Hickstein R, Wiesemann S, Viezzer D, Kleindienst D, Chitiboi T, Gheorghita BA, Wetzl J, Hadler T, Dietrich S, Schmitter S, Schulz-Menger J.   +10 more
europepmc   +1 more source

Molecular characterisation of Staphylococcus aureus in school-age children in Guangzhou: associations among agr types, virulence genes, sequence types, and antibiotic resistant phenotypes. [PDF]

BMC Microbiol, 2023
Cai H, Li X, Zhang C, Zhong H, Xie Y, Huang L, Zhang B, Long Y, Zhou Z, Liang B.   +9 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Genomic differences between sequence types 1 and 104 of Streptococcus suis Serotype 2. [PDF]

PeerJ, 2022
Kerdsin A, Takeuchi D, Akeda Y, Nakamura S, Gottschalk M, Oishi K.   +5 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Sequence Types and Antimicrobial Resistance Profiles of Salmonella Typhimurium in the Food Chain in Singapore. [PDF]

Microorganisms
Lim YC, Ong KH, Khor WC, Chua FYX, Lim JQ, Tan LK, Chen SL, Wong WK, Maiwald M, Barkham T, Koh TH, Khoo J, Chan JSH, Aung KT.   +13 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Impact of <i>Pseudomonas aeruginosa</i> biofilm formation by different sequence types on treating lower limb vascular infections. [PDF]

Curr Res Microb Sci
Wang Y, Xiao Q, Yang Q, Long Y, Jiang Z, Zhang T, Hu Y, Gao B, Chen X, Wang T, Xiao L.   +10 more
europepmc   +1 more source

Author Correction: Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock. [PDF]

Sci Rep, 2023
El Zowalaty ME, Lamichhane B, Falgenhauer L, Mowlaboccus S, Zishiri OT, Forsythe S, Helmy YA.   +6 more
europepmc   +1 more source