Results 171 to 180 of about 7,026,554 (307)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sequence Types of <i>Cryptococcus neoformans</i> and Their Associations with Clinical Characteristics and Outcomes of AIDS Patients with Cryptococcal Meningitis in Southern China. [PDF]

Pathogens
Li C, Zhang Y, Ke Y, Zhang Y, Chen M, Tao X, Guo P, Chen J, Tang X, Lin W, Li L.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Plasmid-Driven Resistome Diversity in 9700 <i>Escherichia coli</i> Genomes Across Phylogroups and Sequence Types. [PDF]

Antibiotics (Basel)
Azour A, Matar GM, Bilen M.
europepmc   +1 more source

Coastal water bacteriophages infect various sets of Vibrio parahaemolyticus sequence types. [PDF]

Front Microbiol, 2022
Brossard Stoos KA, Ren J, Shields-Cutler RR, Sams KL, Caldwell S, Ho MB, Rivara G, Whistler CA, Jones SH, Wiedmann M, DeMent J, Getchell RG, Marquis H.   +12 more
europepmc   +1 more source

Turyn type sequences

, 2019
In this paper we study the so called Turyn type sequences and some heuristics algorithms to generate them. The importance of these sequences lies, at least, in the fact that they can be used to construct some Hadamard matrices of order 4(3m - 1), where m is the length of the Turyn type sequence through the theorem of Goethals-Seidal.
Segura Ugalde, Esteban, Piza Volio, Eduardo   +1 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btl007 Sequence analysis

, 2008
Motivation: The first version of the graphical multiple sequence alignment environment QAlign was published in 2003. Heavy response from the molecular-biological user community clearly demonstrated the need for such a platform.
Jens Stoye, Thasso Griebel, Michael Sammeth, Felix Tille, Sequence Analysis   +4 more
core  

Listeria monocytogenes of two sequence types in a maternal-fetal listeriosis: clinical management and bacterial genomics. [PDF]

BMC Infect Dis
Liu Z, Wang Y, Wang C, Liu L, Li X, Li G, Wei H, Li Z, Zhao J, Zhang J.   +9 more
europepmc   +1 more source

Distinct evolutionary trajectories in the Escherichia coli pangenome occur within sequence types. [PDF]

Microb Genom, 2022
Cummins EA, Hall RJ, Connor C, McInerney JO, McNally A.   +4 more
europepmc   +1 more source