Results 131 to 140 of about 2,098,916 (269)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Direct RNA Sequencing of Dengue and Chikungunya Viruses with Ultra-Low Input and Custom Multiplexing. [PDF]

J Biomol Tech
Tanvet C, Baum C, O'Connor O, Bohers C, Dupont-Rouzeyrol M, Monot M.   +5 more
europepmc   +1 more source

Sequencing Lung Cancer’s Sequence

American Journal of Respiratory and Critical Care Medicine, 2019
Watanabe, Hideo, Powell, Charles A.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Full-Length 16S rRNA Amplicon Sequencing for the Simple and Simultaneous Detection of Multiple Probiotic Species in Commercial Products. [PDF]

J Microbiol Biotechnol
Kim GE, Gwak YS, Bae CI, Jeong KC, Kim MJ.   +4 more
europepmc   +1 more source

Morse Sequences on Stacks and Flooding Sequences

This paper builds upon the framework of \emph{Morse sequences}, a simple and effective approach to discrete Morse theory. A Morse sequence on a simplicial complex consists of a sequence of nested subcomplexes generated by expansions and fillings-two operations originally introduced by Whitehead.
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Emerging applications of long-read sequencing in hematological malignancies: highlights from the 2025 ASH annual meeting. [PDF]

Biomark Res
Liu B, Jiang Y, Zhao B, Zhu HH.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Rapid identification of microbial pathogens and antimicrobial resistance from bloodstream infections using long-read sequencing. [PDF]

Microb Genom
Lerminiaux N, Fakharuddin K, Adam HJ, Bharat A, Golding GR, Martin I, Mulvey M, Mataseje LF.   +7 more
europepmc   +1 more source