Results 41 to 50 of about 3,312,497 (352)

Biological and technical factors in the assessment of blood-based tumor mutational burden (bTMB) in patients with NSCLC

Journal for ImmunoTherapy of Cancer, 2022
Background Patients treated with immunotherapy are at risk of considerable adverse events, and the ongoing struggle is to accurately identify the subset of patients who will benefit.
Kim Monkhorst, Daniel Klass, Milou Schuurbiers, Zhongyun Huang, Senglor Saelee, Manana Javey, Leonie de Visser, Daan van den Broek, Michel van den Heuvel, Alexander F Lovejoy   +9 more
doaj   +1 more source

Potter′s sequence

Journal of Clinical Neonatology, 2012
Potter's sequence is a rare fatal disorder that occurs in sporadic and autosomal recessive forms with an incidence of 1 in 4000 births. Babies born with this condition are either still born or die very early within the neonatal period. We report a case of Potter's sequence with the typical physical findings and histological findings.
Shastry, Srikanth M., Kolte, Sachin S., Sanagapati, Panduranga R.   +2 more
openaire   +3 more sources

Heparin sequencing [PDF]

Glycobiology, 2002
Heparin is a highly sulfated glycosaminoglycan widely used as an anticoagulant. Modifications in its relatively uniform structure appear to be key to its recognition and modulation of serine proteases, growth factors, chemokines, and extracellular proteins, as has been most clearly demonstrated in the antithrombin binding site.
Stringer, Sally E., Kandola, Balbant S., Pye, David A., Gallagher, John T.   +3 more
openaire   +2 more sources

Long-Read Sequencing as a Diagnostic Tool for Primary Ciliary Dyskinesia

Case Reports in Genetics
Primary ciliary dyskinesia (PCD) is a rare, inherited disease resulting from abnormal structure and/or function of cilia. To date, pathogenic variants in over 50 genes have been reported as causes of PCD.
Liora H. Feshbach, Morgan Similuk, Laura M. Amendola, Katie L. Lewis, Magdalena A. Walkiewicz, Mari Tokita, Rajarshi Ghosh, Andrew Lipton   +7 more
doaj   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment

Microbiome, 2017
Background Colonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C.
Sepideh Pakpour, Amit Bhanvadia, Roger Zhu, Abhimanyu Amarnani, Sean M. Gibbons, Thomas Gurry, Eric J. Alm, Laura A. Martello   +7 more
doaj   +1 more source

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. [PDF]

, 2010
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS),
A Bird, A Hellman, A Meissner, AD Smith, Adam Olshen, AK Maunakea, Aleksandar Milosavljevic, Alexander Meissner, Allen Delaney, Andreas Gnirke, AP Feinberg, B Langmead, Bing Ren, Bradley E Bernstein, Brett E Johnson, C Coarfa, C Grunau, Charles B Epstein, Chibo Hong, Christoph Bock, Cristian Coarfa, D Serre, David Haussler, DM Duhl, FV Jacinto, G Bourque, G Kunarso, G Robertson, H Gu, H Lin, H O'Geen, Henriette O'Geen, Hongcang Gu, J Deng, Joseph F Costello, Joseph R Ecker, Junchen Gu, KD Robertson, Kevin J Forsberg, KR Blahnik, KS Pollard, LC Schalkwyk, Lorigail Echipare, M Pick, M Tahiliani, MA Gama-Sosa, Marco A Marra, Martin Hirst, Mattia Pelizzola, Michael Q Zhang, MP Ball, P Arnaud, Peggy J Farnham, PVK Pant, R Alan Harris, R David Hawkins, R Lister, R Lister, RA Waterland, RA Waterland, Raman P Nagarajan, Robert A Waterland, Ryan Lister, S Ito, S Kriaucionis, Sara L Downey, Shaun D Fouse, SJ Cokus, T Wang, TA Down, TE Ludwig, Ting Wang, Tracy Ballinger, Wei Li, Wen-Yu Chung, Xin Zhou, Y Xi, Yongjun Zhao, Yuanxin Xi, ZD Smith   +79 more
core   +2 more sources

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Assessment of Antibiotic Resistance and Efflux Pump Gene Expression in Neisseria Gonorrhoeae Isolates from South Africa by Quantitative Real-Time PCR and Regression Analysis

International Journal of Microbiology, 2022
Introduction. Treatment of gonorrhoea infection is limited by the increasing prevalence of multidrug-resistant strains. Cost-effective molecular diagnostic tests can guide effective antimicrobial stewardship.
Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus, Koleka P. Mlisana   +10 more
doaj   +1 more source

The sequence of sequencers: The history of sequencing DNA

Genomics, 2016
Determining the order of nucleic acid residues in biological samples is an integral component of a wide variety of research applications. Over the last fifty years large numbers of researchers have applied themselves to the production of techniques and technologies to facilitate this feat, sequencing DNA and RNA molecules. This time-scale has witnessed
Heather, JM, Chain, B
openaire   +3 more sources