Results 111 to 120 of about 622,755 (276)
Shorter planning depth and higher response noise during sequential decision-making in old age. [PDF]
Sci Rep, 2023 Steffen J +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
A non-parametric Bayesian approach for adjusting partial compliance in sequential decision making. [PDF]
Stat Med, 2023 Bhattacharya I +6 more
europepmc +1 more source
Two-stage Boundedly Rational Choice Procedures: Theory and Experimental Evidence [PDF]
We study and test a class of boundedly rational models of decision making which rely on sequential eliminative heuristics. We formalize two sequential decision procedures, both inspired by plausible models popular among several psychologists and ...
Marco Mariotti, Paola Manzini
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Data Generation as Sequential Decision Making
, 2015 We connect a broad class of generative models through their shared reliance on sequential decision making. Motivated by this view, we develop extensions to an existing model, and then explore the idea further in the context of data imputation -- perhaps the simplest setting in which to investigate the relation between unconditional and conditional ...
Bachman, Philip, Precup, Doina
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Applied SciencesAttachment styles, rooted in Bowlby’s Attachment Theory, significantly influence our romantic relationships, workplace behavior, and decision-making processes.
Dor Mizrahi, Ilan Laufer, Inon Zuckerman
doaj +1 more source
The effect of apathy and compulsivity on planning and stopping in sequential decision-making. [PDF]
PLoS Biol, 2022 Scholl J +3 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source