Results 151 to 160 of about 234,706 (300)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

TACTICAL ANALYSIS OF ELITE FOOTBALL TEAMS – A MIXED METHOD APROACH

E-balonmano.com: Revista de Ciencias del Deporte, 2015
Soccer is a game with a random intermittent nature, whereby critical elements of the game are sometimes determined by chance. Research on match analysis in this sport has been mainly focused on the description of physical, physiological and technical ...
Hugo Sarmento, Antonino Pereira, Jorge Campaniço, Jorge Arede, José Leitão   +4 more
doaj  

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Game Theory Applied To The Brazilian Antitrust Leniency Program

Direito Público
The Brazilian Antitrust Law established the Administrative Council for Economic Defence (CADE) as the body responsible for investigating and imposing sanctions for acts that violate the economic order, as well as for supervising acts of economic ...
Douglas Matias Sabino, Fabiano Teodoro de Rezende Lara, Elisa Santos Coelho Sarto   +2 more
doaj  

Análise sequencial e suas possibilidades: uma revisão de literatura

Revista Brasileira de Futsal e Futebol, 2015
Sendo o jogo de futebol um sistema aberto, dinâmico, complexo e não linear, no qual coexistem subsistemas hierarquizados que interagem por meio de possibilidades de conexões múltiplas (Castelo, 1999), a observação poderia ser vista como algo ...
Kaio Cesar Gratão Fonseca, Antonio Coppi Navarro   +1 more
doaj  

A quantum Stackelberg common-pool resource game

APL Quantum
A sequential common-pool resource game with variable elastic marginal profit is studied in this work both analytically and through numerical simulation. The game is studied in both classic and quantum approaches considering symmetric and asymmetric costs.
Luis Garcia-Perez, Juan Grau-Climent, Juan C. Losada, Ramon Alonso-Sanz   +3 more
doaj   +1 more source

The Cournot outcome as the result of price competition [PDF]

In a homogeneous product duopoly with concave revenue and convex costs we study a two stage game in which, first, firms engage simultaneously in capacity (production) and, after production levels are made public, there is sequential price competition in ...
Pedro Jara-Moroni
core  

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Unveiling the Role of Curvature in Carbon for Improved Energy Release of Ammonium Perchlorate

Advanced Materials, EarlyView.
High‐curvature carbon materials identified via machine learning and simulation can enhance the heat release and combustion performance of ammonium perchlorate. ABSTRACT The catalytic role of carbon curvature in the thermal decomposition of ammonium perchlorate (AP) remains largely unexplored. To address this gap, this study employs machine learning and
Dan Liu, Keliang Song, Haorui Zhang, Zhipeng Liu, Guansong He, Junru Wang, Wenming Yang, Xu Zhao, Zhijian Yang   +8 more
wiley   +1 more source