Results 11 to 20 of about 10,729 (166)

Autophagy regulates rRNA synthesis

Nucleus, 2022
Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
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Nonhistone Lysine Methylation as a Protein Degradation Signal

Journal of Chemistry, 2022
Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best characterized mechanism of targeting a protein for degradation; however, there are a growing ...
Nicholas A. Lehning, Brad E. Morrison
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The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou, Yuhao Zhou, Shucheng Hua, Shucheng Hua, Lei Song, Lei Song   +5 more
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Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity [PDF]

The American Journal of Pathology, 2016
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group.
Ann F, Hubbs, Kara L, Fluharty, Rebekah J, Edwards, Jamie L, Barnabei, John T, Grantham, Scott M, Palmer, Francine, Kelly, Linda M, Sargent, Steven H, Reynolds, Robert R, Mercer, Madhusudan P, Goravanahally, Michael L, Kashon, John C, Honaker, Mark C, Jackson, Amy M, Cumpston, William T, Goldsmith, Walter, McKinney, Jeffrey S, Fedan, Lori A, Battelli, Tiffany, Munro, Winnie, Bucklew-Moyers, Kimberly, McKinstry, Diane, Schwegler-Berry, Sherri, Friend, Alycia K, Knepp, Samantha L, Smith, Krishnan, Sriram   +26 more
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Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]

Middle East Journal of Cancer, 2021
Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj, Amir Mahmoudzadeh, Saeid Ghavami, Pooneh Mokarram   +3 more
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Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins [PDF]

Journal of Biological Chemistry, 2008
Sequestosome 1 (SQSTM1)/p62 is an interacting partner of the atypical protein kinase C zeta/iota and serves as a scaffold for cell signaling and ubiquitin binding, which is critical for several cell functions in vivo such as osteoclastogenesis, adipogenesis, and T cell activation.
Marie W, Wooten, Thangiah, Geetha, J Ramesh, Babu, M Lamar, Seibenhener, Junmin, Peng, Nancy, Cox, Maria-T, Diaz-Meco, Jorge, Moscat   +7 more
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Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation [PDF]

Molecular and Cellular Biology, 2004
Herein, we demonstrate that the ubiquitin-associated (UBA) domain of sequestosome 1/p62 displays a preference for binding K63-polyubiquitinated substrates. Furthermore, the UBA domain of p62 was necessary for aggregate sequestration and cell survival.
M Lamar, Seibenhener, Jeganathan Ramesh, Babu, Thangiah, Geetha, Hing C, Wong, N Rama, Krishna, Marie W, Wooten   +5 more
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A viroporin-like 2B protein of duck hepatitis A virus 1 that induces incomplete autophagy in DEF cells

Poultry Science, 2021
: Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Zezheng Liu, Qian Ye, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Juan Huang, Qun Gao, Bin Tian, Mingshu Wang   +13 more
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CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

Frontiers in Cell and Developmental Biology, 2021
p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer.
Liyan Gong, Liyan Gong, Kaihua Wang, Kaihua Wang, Mengcheng Wang, Mengcheng Wang, Ronggui Hu, Ronggui Hu, Huaguang Li, Daming Gao, Daming Gao, Moubin Lin, Moubin Lin   +12 more
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New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone [PDF]

Endocrine Reviews, 2013
Paget's disease of bone (PDB) is characterized by focal areas of aberrant and excessive bone turnover, specifically increased bone resorption and disorganized bone formation. Germline mutations in the sequestosome 1/p62 (SQSTM1/p62) gene are common in PDB patients, with most mutations affecting the ubiquitin-associated domain of the protein.
Sarah L, Rea, John P, Walsh, Robert, Layfield, Thomas, Ratajczak, Jiake, Xu   +4 more
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