Results 11 to 20 of about 32,322,339 (203)

A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate. [PDF]

J Biol Chem, 2018
The inflammasome is a major component of the innate immune system, and its main function is to activate caspase-1, a cysteine protease that promotes inflammation by inducing interleukin-1β (IL-1β) maturation and release into the extracellular milieu. To prevent uncontrolled inflammation, this complex is highly regulated.
Jamilloux Y, Lagrange B, Di Micco A, Bourdonnay E, Provost A, Tallant R, Henry T, Martinon F.   +7 more
europepmc   +9 more sources

Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts [PDF]

Biochemical and Biophysical Research Communications, 2010
Paget's disease of bone (PDB) is a late-onset disorder characterised by focal areas of increased bone resorption, with osteoclasts that are increased in size, multinuclearity, number and activity. PDB-causing missense and nonsense variants in the gene encoding Sequestosome-1/p62 (SQSTM1) have been identified, all of which cluster in and around the ...
Hocking, Lynne J., Mellis, David J., McCabe, Paul S., Helfrich, Miep H., Rogers, Michael J.   +4 more
openaire   +5 more sources

p62/Sequestosome-1

Veterinary Pathology, 2014
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich, R T G, Dean, C G, Lamm, F, Ramiro-Ibañez, M L, Stevenson, J C, Patterson-Kane   +5 more
openaire   +3 more sources

Sequestosome 1 Is Part of the Interaction Network of VAPB [PDF]

, 2022
VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane.
Urlaub, Henning; 2Bioanalytics Group, Institute of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany; christof.lenz@med.uni-goettingen.de (C.L.); henning.urlaub@mpibpc.mpg.de (H.U.), Kehlenbach, Ralph H.; 1Department of Molecular Biology, Faculty of Medicine, GZMB (Göttinger Zentrum für Molekulare Biowissenschaften), Georg-August-University Göttingen, Humboldtallee 23, 37073 Göttingen, Germany, Lenz, Christof, Urlaub, Henning, James, Christina; 1Department of Molecular Biology, Faculty of Medicine, GZMB (Göttinger Zentrum für Molekulare Biowissenschaften), Georg-August-University Göttingen, Humboldtallee 23, 37073 Göttingen, Germany, Kehlenbach, Ralph H., Lenz, Christof; 2Bioanalytics Group, Institute of Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany; christof.lenz@med.uni-goettingen.de (C.L.); henning.urlaub@mpibpc.mpg.de (H.U.), James, Christina   +7 more
core   +2 more sources

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins [PDF]

Journal of Biological Chemistry, 2008
Sequestosome 1 (SQSTM1)/p62 is an interacting partner of the atypical protein kinase C zeta/iota and serves as a scaffold for cell signaling and ubiquitin binding, which is critical for several cell functions in vivo such as osteoclastogenesis, adipogenesis, and T cell activation.
Marie W, Wooten, Thangiah, Geetha, J Ramesh, Babu, M Lamar, Seibenhener, Junmin, Peng, Nancy, Cox, Maria-T, Diaz-Meco, Jorge, Moscat   +7 more
openaire   +2 more sources

Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity [PDF]

The American Journal of Pathology, 2016
Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group.
Ann F, Hubbs, Kara L, Fluharty, Rebekah J, Edwards, Jamie L, Barnabei, John T, Grantham, Scott M, Palmer, Francine, Kelly, Linda M, Sargent, Steven H, Reynolds, Robert R, Mercer, Madhusudan P, Goravanahally, Michael L, Kashon, John C, Honaker, Mark C, Jackson, Amy M, Cumpston, William T, Goldsmith, Walter, McKinney, Jeffrey S, Fedan, Lori A, Battelli, Tiffany, Munro, Winnie, Bucklew-Moyers, Kimberly, McKinstry, Diane, Schwegler-Berry, Sherri, Friend, Alycia K, Knepp, Samantha L, Smith, Krishnan, Sriram   +26 more
openaire   +2 more sources

A viroporin-like 2B protein of duck hepatitis A virus 1 that induces incomplete autophagy in DEF cells

Poultry Science, 2021
: Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Zezheng Liu, Qian Ye, Anchun Cheng, Xumin Ou, Sai Mao, Di Sun, Shaqiu Zhang, Xinxin Zhao, Qiao Yang, Ying Wu, Juan Huang, Qun Gao, Bin Tian, Mingshu Wang   +13 more
doaj   +1 more source

Dataset for the Sequestosome-1 antibody screening study

, 2023
This project contains the following underlying data included in a study aiming at characterizing antibodies for the Sequestosome-1 protein. The study is available on Zenodo (https://doi.org/10.5281/zenodo.4818440)
Laflamme, Carl
core   +1 more source

Intramolecular quality control: HIV-1 envelope gp160 signal-peptide cleavage as a functional folding checkpoint [PDF]

, 2021
Removal of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding.
Sub Cellular Protein Chemistry, Quandte, Matthias, Land, Aafke, McCaul, Nicholas, Sanders, Rogier W., Crooks, Ema T., Bontjer, Ilja, Binley, James M., van Zadelhoff, Guus, Braakman, Ineke, Cellular Protein Chemistry   +10 more
core   +2 more sources

CUL5–ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and Degradation to Regulate Cell Proliferation and Autophagy

Frontiers in Cell and Developmental Biology, 2021
p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer.
Liyan Gong, Liyan Gong, Kaihua Wang, Kaihua Wang, Mengcheng Wang, Mengcheng Wang, Ronggui Hu, Ronggui Hu, Huaguang Li, Daming Gao, Daming Gao, Moubin Lin, Moubin Lin   +12 more
doaj   +1 more source