Results 21 to 30 of about 32,322,339 (203)
New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone [PDF]
Endocrine Reviews, 2013 Paget's disease of bone (PDB) is characterized by focal areas of aberrant and excessive bone turnover, specifically increased bone resorption and disorganized bone formation. Germline mutations in the sequestosome 1/p62 (SQSTM1/p62) gene are common in PDB patients, with most mutations affecting the ubiquitin-associated domain of the protein.
Sarah L, Rea +4 more
openaire +2 more sources
Autophagy and p62/sequestosome 1 generate neo-antimicrobial peptides (cryptides) from cytosolic proteins [PDF]
Autophagy, 2011 In a manifestation of the immunological autophagy termed xenophagy, autophagic adapter proteins such as p62 and NDP52 directly capture microbes for delivery to autophagosomal organelles where they are eliminated. In a mirror image phenomenon, which is also an immunological variant of the process termed decryption, p62 and autophagy contribute to the ...
Marisa, Ponpuak, Vojo, Deretic
openaire +2 more sources
Does Exercise Regulate Autophagy in Humans? A Systematic Review and Meta-Analysis
Autophagy Reports, 2023 Background Macroautophagy/autophagy is an essential recycling process that is involved in a wide range of biological functions as well as in diseases. The regulation of autophagy by exercise and the associated health benefits have been revealed by rodent
Xiang-Ke Chen +5 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Background: To observe the changes of autophagy-related protein levels in peripheral blood lymphocytes before and after sirolimus treatment in children with systemic lupus erythematosus (SLE).Methods: Children with SLE were randomly divided into two ...
Xinliang Wang +7 more
doaj +1 more source
Precision Radiation Oncology, 2020 Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj +1 more source
Virus Research, 2022 Coxsackievirus B3 (CVB3) is a positive single-strand RNA virus causing myocarditis, pancreatitis and meningitis. During CVB3 infection, various host cellular components, including proteins and non-coding RNAs, interact with the virus and affect viral ...
Hong-Yan He +11 more
doaj +1 more source
Sequestosome 1/p62 – More than just a scaffold [PDF]
, 2007 The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/
Geetha, Thangiah +2 more
core +1 more source
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]
, 2018 Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry +7 more
core +1 more source
Antioxidants, 2022 Lipophagy, a type of autophagy that breaks down lipid droplets, is essential in the regulation of intracellular lipid accumulation and intracellular free fatty acid levels in numerous organisms and metabolic conditions.
Miey Park +5 more
doaj +1 more source