Results 31 to 40 of about 10,729 (166)

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1

Frontiers in Immunology, 2019
There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses.
Serge Nataf, Serge Nataf, Serge Nataf, Marine Guillen, Laurent Pays, Laurent Pays, Laurent Pays   +6 more
doaj   +1 more source

Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish

Frontiers in Endocrinology, 2023
IntroductionRecent reports indicate that mitochondrial quality decreases during non-alcoholic fatty liver disease (NAFLD) progression, and targeting the mitochondria may be a possible treatment for NAFLD.
Yun-Yi Zou, Xiang-bin Tang, Zhang-Lin Chen, Bin Liu, Lan Zheng, Ming-Yang Song, Qin Xiao, Zuo-Qiong Zhou, Xi-Yang Peng, Chang-Fa Tang   +9 more
doaj   +1 more source

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation [PDF]

Hepatology, 2018
Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated with the accumulation of insoluble protein aggregates that are composed of ubiquitinated proteins and ubiquitin adaptor p62/sequestosome 1 (SQSTM1).
Cho, Chun‐seok, Park, Hwan‐woo, Ho, Allison, Semple, Ian A., Kim, Boyoung, Jang, Insook, Park, Haeli, Reilly, Shannon, Saltiel, Alan R., Lee, Jun Hee   +9 more
openaire   +3 more sources

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

Frontiers in Cell and Developmental Biology, 2022
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V. Kumar, Joslyn Mills, Louis R. Lapierre   +2 more
doaj   +1 more source

Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

Cell Death and Disease, 2021
Vacuole membrane protein 1 (VMP1), the endoplasmic reticulum (ER)-localized autophagy protein, plays a key role during the autophagy process in mammalian cells.
Panpan Wang, Xi Chen, Yuanyuan Wang, Congcong Jia, Xinyao Liu, Ying Wang, Haifeng Wu, Huaibin Cai, Han-Ming Shen, Weidong Le   +9 more
doaj   +1 more source

UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

eLife, 2021
To adapt in an ever-changing environment, cells must integrate physical and chemical signals and translate them into biological meaningful information through complex signaling pathways.
Stéphanie Torrino, Victor Tiroille, Bastien Dolfi, Maeva Dufies, Charlotte Hinault, Laurent Bonesso, Sonia Dagnino, Jennifer Uhler, Marie Irondelle, Anne-sophie Gay, Lucile Fleuriot, Delphine Debayle, Sandra Lacas-Gervais, Mireille Cormont, Thomas Bertero, Frederic Bost, Jerome Gilleron, Stephan Clavel   +17 more
doaj   +1 more source

The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved]

F1000Research
Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways.
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Walaa Alshafie, Irina Shlaifer   +5 more
doaj   +1 more source

The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection [PDF]

Journal of Virology, 2019
Autophagy is a homeostatic mechanism of cells to recycle components, as well as a defense mechanism to get rid of pathogens. Strategies that HSV-1 has developed to counteract autophagy have been described and involve inhibition of autophagosome formation or indirect mechanisms.
Hope, Waisner, Maria, Kalamvoki
openaire   +2 more sources

The selective autophagic degradation of avian metapneumovirus subgroup C M2-2 protein via SQSTM1 suppresses viral replication

Autophagy Reports
Avian metapneumovirus subgroup C (aMPV/C) is an emerging pathogen that causes acute respiratory infection in chickens and turkeys. Sequestosome 1 (SQSTM1), a selective autophagy receptor, regulates cellular activity or viral replication by recognizing ...
Lei Hou, Jinshuo Guo, Jianwei Zhou, Jue Liu   +3 more
doaj   +1 more source