Results 31 to 40 of about 10,678 (163)
The role of autophagy related signal transduction pathways in bone metabolism [PDF]
Yixue xinzhi zazhi, 2022 Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation.
Zhi-Zhuo LI +3 more
doaj +1 more source
Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj +1 more source
Nonhistone Lysine Methylation as a Protein Degradation Signal
Journal of Chemistry, 2022 Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best characterized mechanism of targeting a protein for degradation; however, there are a growing ...
Nicholas A. Lehning, Brad E. Morrison
doaj +1 more source
The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection
Frontiers in Cellular and Infection Microbiology, 2023 As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou +5 more
doaj +1 more source
Autophagy Flux Correlates with Upregulation of AKT-1 in RAS Mutated Colon Cancer Cells [PDF]
Middle East Journal of Cancer, 2021 Background: The AKT/PKB (protein kinase B) kinase is the main regulator of autophagy in mammalian cells, which consists of three isoforms, including AKT-1, AKT-2, and AKT-3.
Hamid Behrouj +3 more
doaj +1 more source
Poultry Science, 2021 : Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious hepatitis in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that
Zezheng Liu +13 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, cell death, and survival. Therefore, it is implicated in human diseases such as obesity and cancer.
Liyan Gong +12 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Background: To observe the changes of autophagy-related protein levels in peripheral blood lymphocytes before and after sirolimus treatment in children with systemic lupus erythematosus (SLE).Methods: Children with SLE were randomly divided into two ...
Xinliang Wang +7 more
doaj +1 more source
Does Exercise Regulate Autophagy in Humans? A Systematic Review and Meta-Analysis
Autophagy Reports, 2023 Background Macroautophagy/autophagy is an essential recycling process that is involved in a wide range of biological functions as well as in diseases. The regulation of autophagy by exercise and the associated health benefits have been revealed by rodent
Xiang-Ke Chen +5 more
doaj +1 more source
Virus Research, 2022 Coxsackievirus B3 (CVB3) is a positive single-strand RNA virus causing myocarditis, pancreatitis and meningitis. During CVB3 infection, various host cellular components, including proteins and non-coding RNAs, interact with the virus and affect viral ...
Hong-Yan He +11 more
doaj +1 more source