Results 31 to 40 of about 32,322,339 (203)

Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]

, 2012
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V., Sub Cellular Protein Chemistry, Sebera, J., Tanaka, Y., Trantirek, L., Cellular Protein Chemistry   +5 more
core   +1 more source

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Frontiers in Cell and Developmental Biology, 2020
Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity.
Erik L. Friesen, Erik L. Friesen, Yu Tong Zhang, Yu Tong Zhang, Rebecca Earnshaw, Rebecca Earnshaw, Mitch L. De Snoo, Mitch L. De Snoo, Darren M. O’Hara, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Sophie Ngana, Kevin S. Chen, Kevin S. Chen, Lorraine V. Kalia, Lorraine V. Kalia, Lorraine V. Kalia, Suneil K. Kalia, Suneil K. Kalia, Suneil K. Kalia   +21 more
doaj   +1 more source

Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue

Autophagy Reports, 2023
Autophagy is a central process responsible for the disposal of normal as well as damaged cellular proteins and organelles. Proper regulation of multiple steps – including initiation and the fusion between autophagosomes and lysosomes – is essential for ...
Yungui Guo, Erika R. Geisbrecht
doaj   +1 more source

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

Immunohistochemical Expression of p62 in Feline Mammary Carcinoma and Non-Neoplastic Mammary Tissue

Animals, 2022
The p62 protein, also called sequestosome 1 (SQSTM1), is a ubiquitin-binding scaffold protein. In human oncology, although the interest in the function of this protein is recent, the knowledge is now numerous, but its role in tumorigenesis is not yet ...
Gian Enrico Magi, Francesca Mariotti, Lorenzo Pallotta, Alessandro Di Cerbo, Franco Maria Venanzi   +4 more
doaj   +1 more source

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation [PDF]

Hepatology, 2018
Obesity commonly leads to hepatic steatosis, which often provokes lipotoxic injuries to hepatocytes that cause nonalcoholic steatohepatitis (NASH). NASH, in turn, is associated with the accumulation of insoluble protein aggregates that are composed of ubiquitinated proteins and ubiquitin adaptor p62/sequestosome 1 (SQSTM1).
Cho, Chun‐seok, Park, Hwan‐woo, Ho, Allison, Semple, Ian A., Kim, Boyoung, Jang, Insook, Park, Haeli, Reilly, Shannon, Saltiel, Alan R., Lee, Jun Hee   +9 more
openaire   +3 more sources

Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1

Frontiers in Immunology, 2019
There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses.
Serge Nataf, Serge Nataf, Serge Nataf, Marine Guillen, Laurent Pays, Laurent Pays, Laurent Pays   +6 more
doaj   +1 more source

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]

, 2013
p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
Wang, W, Chen, Z, Gao Wentao, Wang, Wei, Gao, Wentao, Zhixia Chen, Wentao Gao, Wang Wei, Stang Michael T., Michael T Stang, Chen, Zhixia, Michael T. Stang, Gao, W, Wei Wang, Stang, MT, Stang, Michael T., Zhu, Wei-Guo, Chen Zhixia   +17 more
core   +2 more sources

Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish

Frontiers in Endocrinology, 2023
IntroductionRecent reports indicate that mitochondrial quality decreases during non-alcoholic fatty liver disease (NAFLD) progression, and targeting the mitochondria may be a possible treatment for NAFLD.
Yun-Yi Zou, Xiang-bin Tang, Zhang-Lin Chen, Bin Liu, Lan Zheng, Ming-Yang Song, Qin Xiao, Zuo-Qiong Zhou, Xi-Yang Peng, Chang-Fa Tang   +9 more
doaj   +1 more source

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]

, 2018
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias, Sub Cellular Protein Chemistry, Kityk, R., Rüdiger, S.G.D., Morán Luengo, T., Cellular Protein Chemistry   +5 more
core   +2 more sources