Results 41 to 50 of about 10,678 (163)

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
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Stevia and Stevioside Attenuate Liver Steatosis through PPARα-Mediated Lipophagy in db/db Mice Hepatocytes

Antioxidants, 2022
Lipophagy, a type of autophagy that breaks down lipid droplets, is essential in the regulation of intracellular lipid accumulation and intracellular free fatty acid levels in numerous organisms and metabolic conditions.
Miey Park, Anshul Sharma, Hana Baek, Jin-Young Han, Junho Yu, Hae-Jeung Lee   +5 more
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Immunohistochemical Expression of p62 in Feline Mammary Carcinoma and Non-Neoplastic Mammary Tissue

Animals, 2022
The p62 protein, also called sequestosome 1 (SQSTM1), is a ubiquitin-binding scaffold protein. In human oncology, although the interest in the function of this protein is recent, the knowledge is now numerous, but its role in tumorigenesis is not yet ...
Gian Enrico Magi, Francesca Mariotti, Lorenzo Pallotta, Alessandro Di Cerbo, Franco Maria Venanzi   +4 more
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Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue

Autophagy Reports, 2023
Autophagy is a central process responsible for the disposal of normal as well as damaged cellular proteins and organelles. Proper regulation of multiple steps – including initiation and the fusion between autophagosomes and lysosomes – is essential for ...
Yungui Guo, Erika R. Geisbrecht
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BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Frontiers in Cell and Developmental Biology, 2020
Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity.
Erik L. Friesen, Erik L. Friesen, Yu Tong Zhang, Yu Tong Zhang, Rebecca Earnshaw, Rebecca Earnshaw, Mitch L. De Snoo, Mitch L. De Snoo, Darren M. O’Hara, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Sophie Ngana, Kevin S. Chen, Kevin S. Chen, Lorraine V. Kalia, Lorraine V. Kalia, Lorraine V. Kalia, Suneil K. Kalia, Suneil K. Kalia, Suneil K. Kalia   +21 more
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SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
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Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish

Frontiers in Endocrinology, 2023
IntroductionRecent reports indicate that mitochondrial quality decreases during non-alcoholic fatty liver disease (NAFLD) progression, and targeting the mitochondria may be a possible treatment for NAFLD.
Yun-Yi Zou, Xiang-bin Tang, Zhang-Lin Chen, Bin Liu, Lan Zheng, Ming-Yang Song, Qin Xiao, Zuo-Qiong Zhou, Xi-Yang Peng, Chang-Fa Tang   +9 more
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Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1

Frontiers in Immunology, 2019
There is circumstantial evidence that, under neurodegenerative conditions, peptides deriving from aggregated or misfolded specific proteins elicit adaptive immune responses.
Serge Nataf, Serge Nataf, Serge Nataf, Marine Guillen, Laurent Pays, Laurent Pays, Laurent Pays   +6 more
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Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

Frontiers in Cell and Developmental Biology, 2022
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V. Kumar, Joslyn Mills, Louis R. Lapierre   +2 more
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Essential role for autophagy protein VMP1 in maintaining neuronal homeostasis and preventing axonal degeneration

Cell Death and Disease, 2021
Vacuole membrane protein 1 (VMP1), the endoplasmic reticulum (ER)-localized autophagy protein, plays a key role during the autophagy process in mammalian cells.
Panpan Wang, Xi Chen, Yuanyuan Wang, Congcong Jia, Xinyao Liu, Ying Wang, Haifeng Wu, Huaibin Cai, Han-Ming Shen, Weidong Le   +9 more
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