Results 1 to 10 of about 24,707 (161)

SQSTM1 Mutations and Glaucoma. [PDF]

PLoS ONE, 2016
Glaucoma is the most common cause of irreversible blindness worldwide. One subset of glaucoma, normal tension glaucoma (NTG) occurs in the absence of high intraocular pressure.
Todd E Scheetz, Ben R Roos, Frances Solivan-Timpe, Kathy Miller, Adam P DeLuca, Edwin M Stone, Young H Kwon, Wallace L M Alward, Kai Wang, John H Fingert   +9 more
doaj   +4 more sources

Association of p62/SQSTM1 excess and oral carcinogenesis. [PDF]

PLoS ONE, 2013
p62/SQSTM1 (sequestosome1) has never been evaluated in oral epithelium. In order to clarify the role of p62/SQSTM1 in carcinogenesis in oral epithelium, both p62/SQSTM1 and Nrf2 were immunohistochemically evaluated in 54 carcinomas and 14 low grade ...
Takuma Inui, Tokuhiro Chano, Mikiko Takikita-Suzuki, Masanori Nishikawa, Gaku Yamamoto, Hidetoshi Okabe   +5 more
doaj   +4 more sources

SQSTM1/p62 as a therapeutic target in cancer

Autophagy Reports, 2022
Cell survival depends on dynamic interactions among the signaling pathways that control the endoplasmic reticulum (ER) stress response, macroautophagy/autophagy and apoptotic cell death.
Hyeong-Reh C. Kim, Abdo J. Najy, Seongho Kim, Yong Tae Kwon   +3 more
doaj   +3 more sources

Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies

Autophagy
SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs.
Evelina Valionyte, Shouqing Luo
exaly   +3 more sources

SQSTM1/p62 at the Crossroads of Autophagy, Inflammation, and Lethal Infection [PDF]

Cells
Sequestosome 1 (SQSTM1, also known as p62) has emerged as a multifunctional signaling adaptor that bridges autophagy, proteostasis, and inflammation. In this review, we discuss the molecular mechanisms by which SQSTM1 regulates selective autophagy and ...
Ruoxi Zhang, Rui Kang, Daolin Tang
doaj   +2 more sources

MG132-mediated inhibition of rabies virus replication via the Nrf2/SQSTM1/PINK1/Parkin autophagy pathway [PDF]

Virology Journal
Rabies virus (RABV), a fatal neurotropic virus, still lacks effective antiviral drugs for treatment once symptoms appear. MG132 acts as a novel therapeutic agent against viral infection, inhibits the degradation of nuclear factor erythroid-derived 2-like
Ying Lin Chi, Nuo Yang, Yuan Xie, Xiaoyan Tao, Pengcheng Yu, Qian Liu, Minghui Zhang, Shu Qing Liu, Wu Yang Zhu   +8 more
doaj   +2 more sources

The lysine methyltransferase KMT5a and p53 regulate the expression of the key autophagy adaptor p62/SQSTM1 in glioblastoma [PDF]

Cell Communication and Signaling
Background KMT5a, a histone lysine methyltransferase responsible for histone H4 lysine 20 monomethylation (H4K20me1), plays a critical role in the pathogenesis of various human diseases, including cancer.
Rosa Della Monica, Michela Buonaiuto, Mariella Cuomo, Denise Drongitis, Maria Giuseppina Miano, Davide Costabile, Giulia de Riso, Federica Trio, Marta Sabbarese, Sara Ferraro, Lorenza Oliva, Nives Piacentino, Rosaria Cappiello, Gianluca Scotti, Vito Alessandro Lasorsa, Mario Capasso, Alberto De Bellis, Marialaura Del Basso De Caro, Lorenzo Chiariotti, Roberta Visconti   +19 more
doaj   +2 more sources

Extracellular SQSTM1 as an inflammatory mediator [PDF]

Autophagy, 2020
Excessive inflammation may lead to irreparable injury and even death, but the key mediators and underlying mechanisms remain unclear. Our recent findings indicate that SQSTM1/p62 (sequestosome 1), a well-known macroautophagy/autophagy receptor, is a lethal inflammatory mediator of sepsis and septic shock.
Borong Zou, Jiao Liu, Daniel J. Klionsky, Daolin Tang, Rui Kang   +4 more
openaire   +2 more sources

Increased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure

Сибирский научный медицинский журнал, 2021
Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment, and maintenance therapy of cancer, as well as overcoming chemoresistance.
S. E. Khrapov, P. M. Kozhin, M. V. Khrapova, A. E. Serykh, L. P. Romakh, V. S. Pavlov, A. V. Chechushkov, S. V. Kholshin, N. K. Zenkov, E. B. Menshchikova   +9 more
doaj   +1 more source

SQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells

eNeurologicalSci, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are genetically, pathologically and clinically-related progressive neurodegenerative diseases.
Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, YongPing Chen, Yutaro Hama, Kai Sato, XuePing Chen, Toshiyasu Suzuki, Hui-Fang Shang, Shinji Hadano   +11 more
doaj   +1 more source