Results 11 to 20 of about 26,505 (243)
Size, Organization and Dynamics of Soluble SQSTM1 and LC3/SQSTM1 Complexes in Living Cells [PDF]
Biophysical Journal, 2016 Selective macroautophagy/autophagy—with the help of molecular receptors—captures cargo for lysosomal degradation. Among the best-studied molecular receptors is SQSTM1/p62, a homo-oligomeric ubiquitin binding protein, which binds to both cargo and MAP1LC3B/LC3, a protein important for autophagosome biogenesis.Kraft, Lewis J., Dowler, Jacob, Manral, Pallavi, Kenworthy, Anne K. +3 moreopenaire +4 more sourcesMeasurement of SQSTM1 by flow cytometry
Autophagy, 2023 Macroautophagy/autophagy is a regulated cellular degradation process essential as a pro-survival mechanism and integral to the regulation of diverse cellular processes in eukaryotes. During cellular stress and nutrient sensing, SQSTM1/p62 (sequestosome 1) functions as a key receptor for selective autophagy by shuttling ubiquitinated cargoes toward ...Jessica C, Hargarten, Guowu, Hu, Waleed, Elsegeiny, Peter R, Williamson +3 moreopenaire +3 more sourcesNeuroimaging Correlates of Frontotemporal Dementia Associated with SQSTM1 Mutations [PDF]
Journal of Alzheimer's Disease, 2016 Background: Frontotemporal lobar degeneration (FTLD) is a progressive dementia characterized by focal atrophy of frontal and/or temporal lobes caused by mutations in the gene coding for sequestosome 1 (SQSTM1), among other genes. Rare SQSTM1 gene mutations have been associated with Paget’s disease of bone, amyotrophic lateral sclerosis, and, more ...Luis, E, Ortiz, A, Eudave, L, Ortega Cubero, S, BORRONI, Barbara, van der Zee, J, Gazzina, S, Caroppo, P, Rubino, E, D'Agata, F, Le Ber, I, Santana, I, Cunha, G, Almeida, Mr, Boutoleau Bretonnière, C, Hannequin, D, Wallon, D, Rainero, I, Galimberti, D, Van Broeckhoven, C, Pastor, Ma, Pastor, P. +21 moreopenaire +5 more sourcesTumor SQSTM1 (p62) expression and T cells in colorectal cancer
OncoImmunology, 2017 Evidence suggests that activation of autophagy in neoplastic cells potentiates antitumor immunity through cross-presentation of tumor-associated antigens to T cells and release of immune mediators.Keisuke Kosumi, Yohei Masugi, Juhong Yang, Zhi Rong Qian, Sun A. Kim, Wanwan Li, Yan Shi, Annacarolina da Silva, Tsuyoshi Hamada, Li Liu, Mancang Gu, Tyler S. Twombly, Yin Cao, David A. Barbie, Katsuhiko Nosho, Hideo Baba, Wendy S. Garrett, Jeffery A. Meyerhardt, Edward L. Giovannucci, Andrew T. Chan, Charles S. Fuchs, Shuji Ogino, Reiko Nishihara +22 moredoaj +2 more sourcesSqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells [PDF]
Journal of Cell Science, 2015 Sqstm1 serves as a signaling hub and receptor for selective autophagy. Consequently, dysregulation of Sqstm1 causes imbalances in signaling pathways and disrupts proteostasis, thereby contributing to the development of human diseases. Environmental stresses influence the level of Sqstm1 by altering its expression and/or autophagic degradation, and also Eino, Atsushi, Kageyama, Shun, Uemura, Takefumi, Annoh, Hiromichi, Saito, Tetsuya, Narita, Ichiei, Waguri, Satoshi, Komatsu, Masaaki +7 moreopenaire +4 more sourcesDHRS9 promotes malignant progression of ovarian cancer through SQSTM1
Journal of Cancer Research and Clinical OncologyObjective This research explores the prognostic value of DHRS9 in ovarian carcinoma and elucidates its regulatory mechanisms. Methods Bioinformatic analyses were applied to clarify the association between DHRS9 expression level and clinical survival ...Yanju Wu, Shu Meng, Haoqi Zhao, Bowen Tan, Jinte Gao, Jingyi Du, Xiaona Meng +6 moredoaj +2 more sourcesIncreased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure
Сибирский научный медицинский журнал, 2021 Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment, and maintenance therapy of cancer, as well as overcoming chemoresistance.S. E. Khrapov, P. M. Kozhin, M. V. Khrapova, A. E. Serykh, L. P. Romakh, V. S. Pavlov, A. V. Chechushkov, S. V. Kholshin, N. K. Zenkov, E. B. Menshchikova +9 moredoaj +1 more sourceRare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration
, 2014 Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort Patrick Santens, Michael T. Heneka, Ellen Gelpi, Bagnoli, Silvia, Alexopoulos, Panagiotis, Matthis Synofzik, Engelborghs, Sebastiaan, Diehl-Schmid, Janine, Thomas Ströbel, Van Langenhove, Tim, Isabel Hernández, Cras, Patrick, Robert Perneczky, Chiang, Huei-Hsin, Schoels, Ludger, Universitat Autònoma de Barcelona. Departament de Medicina, do Couto, Frederico Simões, Kristel Sleegers, Laureys, Annelies, Bonvicini, Christian, Janine Diehl-Schmid, Pau Pastor, Maria Mattheijssens, Schöls, Ludger, Katrien Smets, Julie van der Zee, Caroline Graff, Archetti, Silvana, Cruts, Marc, Binetti, Giuliano, Marc Cruts, Peter Paul De Deyn, Mathieu Vandenbulcke, Maetzler, Walter, Ludger Schöls, Tobias B. Haack, Rik Vandenberghe, Almeida, Maria Rosário, Ströbel, Thomas, Razquin, Cristina, Gian Maria Fabrizi, Bart Dermaut, Vandenbulcke, Mathieu, Mattheijssens, Maria, Sanchez-Valle, Raquel, Ramirez, Alfredo, Albert Llado, Isabel Santana, Van Den Broeck, Marleen, Sandro Sorbi, Ruiz Laza, Agustín, Fabrizi, Gian Maria, Vandenberghe, Rik, van der Zee, Julie, Testi, Silvia, Jennifer Müller vom Hagen, Sara Ortega-Cubero, Dols Icardo, Oriol, Santana, Isabel, Maria Rosário Almeida, Tim Van Langenhove, Synofzik, Matthis, Santiago, Beatriz, Ivailo Tournev, Eric Salmon, Hernández, Isabel, Strom, Tim M, William Deschamps, Alessandro Padovani, Merlin, Céline, HENEKA, Michael, Dillen, Lubina, Deschamps, William, Frederico Simões do Couto, Anne Sieben, Peter De Jonghe, Karin Peeters, Perneczky, Robert, Padovani, Alessandro, Gabriel Miltenberger-Miltényi, Martin, Jean-Jacques, Llado, Albert, Ghidoni, Roberta, Borroni, Barbara, Beatriz Santiago, De Deyn, Peter Paul, Barbara Borroni, Frisoni, Giovanni B, Philip Van Damme, Thonberg, Håkan, Gelpi, Ellen, Silvia Testi, Luisa Benussi, vom Hagen, Jennifer Muller, Peeters, Karin, Kovacs, Gabor G, Raquel Sanchez-Valle, Giovanni B. Frisoni, Boada, Mercè, Müller vom Hagen, Jennifer, Santens, Patrick, Sebastiaan Engelborghs, Kovacs, Gabor G., Clarimón, Jordi, Gabor G. Kovacs, Dols-Icardo, Oriol, Tim M. Strom, Benussi, Luisa, Stroebel, Thomas, Jean-Jacques Martin, Smets, Katrien, Bonvicini, Cristian, Sorbi, Sandro, Frisoni, Giovanni B., Sarafov, Stayko, Radoslav Matěj, Jordanova, Albena, Alexandre de Mendonça, Silvia Bagnoli, Sleegers, Kristel, Llado Plarrumani, Albert, Jessen, Frank, Patrick Cras, Mercè Boada, Céline Merlin, Oriol Dols-Icardo, Haack, Tobias B., Tournev, Ivailo, Håkan Thonberg, Prokisch, Holger, Heneka, Michael T., Alfredo Ramirez, Cristina Razquin, Salmon, Eric, Roberta Ghidoni, Van Damme, Philip, Graff, Caroline, Christian Bonvicini, Frank Jessen, Robberecht, Wim, Panagiotis Alexopoulos, Albena Jordanova, Nacmias, Benedetta, Parobkova, Eva, Ruiz, Agustín, Strom, Tim M., Miltenberger-Miltényi, Gabriel, Simões do Couto, Frederico, De Jonghe, Peter, Wim Robberecht, Agustín Ruiz, Huei-Hsin Chiang, Dermaut, Bart, Lleó, Alberto, Giuliano Binetti, Stayko Sarafov, Ortega-Cubero, Sara, de Mendonça, Alexandre, Silvana Archetti, Walter Maetzler, Lubina Dillen, Annelies Laureys, Matěj, Radoslav, Pastor, Pau, Alberto Lleó, Eva Parobkova, Benedetta Nacmias, Haack, Tobias B, Sieben, Anne, Van Broeckhoven, Christine, Marleen Van Den Broeck, Heneka, Michael T, Holger Prokisch, Christine Van Broeckhoven, Jordi Clarimón +174 morecore +6 more sourcesSQSTM1L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells
eNeurologicalSci, 2021 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are genetically, pathologically and clinically-related progressive neurodegenerative diseases.Masahisa Nozaki, Asako Otomo, Shun Mitsui, Suzuka Ono, Ryohei Shirakawa, YongPing Chen, Yutaro Hama, Kai Sato, XuePing Chen, Toshiyasu Suzuki, Hui-Fang Shang, Shinji Hadano +11 moredoaj +1 more sourceNew in vitro findings about halogenated boroxine cytotoxicity and deregulation of cell death-related genes in GR-M melanoma cells
Arhiv za Higijenu Rada i Toksikologiju, 2023 Anti-proliferative effects of halogenated boroxine – K2(B3O3F4OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown.Elez-Burnjaković Nikolina, Pojskić Lejla, Haverić Anja, Lojo-Kadrić Naida, Omanović Maida Hadžić, Ramić Jasmin, Smajlović Ajla, Maksimović Milka, Haverić Sanin +8 moredoaj +1 more source
