Results 41 to 50 of about 28,326 (246)

p62/SQSTM1 at the interface of aging, autophagy, and disease [PDF]

AGE, 2014
Advanced age is characterized by increased incidence of many chronic, noninfectious diseases that impair the quality of living of the elderly and pose a major burden on the healthcare systems of developed countries. These diseases are characterized by impaired or altered function at the tissue and cellular level, which is a hallmark of the aging ...
Alessandro, Bitto, Chad A, Lerner, Timothy, Nacarelli, Elizabeth, Crowe, Claudio, Torres, Christian, Sell   +5 more
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SQSTM1/p62: A Potential Target for Neurodegenerative Disease [PDF]

ACS Chemical Neuroscience, 2019
Neurodegenerative diseases, characterized by a progressive loss of brain function, affect the lives of millions of individuals worldwide. The complexity of the brain poses a challenge for scientists trying to map the biochemical and physiological pathways to identify areas of pathological errors.
Shifan Ma, Insiya Y. Attarwala, Xiang-Qun Xie   +2 more
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Control of SQSTM1 by NOD2.

, 2023
We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of autophagy receptor p62/sequestosome 1 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
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Role of p62/SQSTM1 in liver physiology and pathogenesis [PDF]

Experimental Biology and Medicine, 2013
p62/sequestosome-1/A170/ZIP (hereafter referred to as p62) is a scaffold protein that has multiple functions, such as signal transduction, cell proliferation, cell survival, cell death, inflammation, tumourigenesis and oxidative stress response. While p62 is an autophagy substrate and is degraded by autophagy, p62 serves as an autophagy receptor for ...
Sharon, Manley, Jessica A, Williams, Wen-Xing, Ding   +2 more
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SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B

Protein Science, 2023
AbstractAutophagy is a highly conserved cellular process that allows degradation of large macromolecules. p62/SQSTM1 is a key adaptor protein that interacts both with material to be degraded and with LC3 at the autophagosome, enabling degradation of cargos such as protein aggregates, lipid droplets and damaged organelles by selective autophagy ...
Alcober‐Boquet, Lucia, Zang, Tabea, Pietsch, Larissa, Suess, Evelyn, Hartmann, Markus, Proschak, Ewgenij, Gross, Lissy Z. F., Sacerdoti, Mariana, Zeuzem, Stefan, Rogov, Vladimir V., Leroux, Alejandro E., Piiper, Albrecht, Biondi, Ricardo M.   +12 more
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Novel SQSTM1 (c.838G>T) Mutation Identified in Two Unrelated Cases of Cerebellar Ataxia and Gaze Palsy

Advanced Biomedical Research
Mutations in the SQSTM1 gene have recently been identified as rare causes of progressive childhood neurodegenerative diseases. To date, only 27 cases have been reported, with 11 different mutations affecting SQSTM1.
Neda Hosseini Moshkenani, Azin Momeni, Amir Bahreini   +2 more
doaj   +1 more source

p62/SQSTM1/A170: Physiology and pathology

Pharmacological Research, 2012
p62/SQSTM1/A170 (hereafter referred to as p62) is a stress-inducible intracellular protein known to regulate various signal transduction pathways involved in cell survival and cell death. Comprehensive analysis of LC3 (an autophagosome localizing protein)-binding proteins resulted in the recognition of autophagy and p62.
Masaaki, Komatsu, Shun, Kageyama, Yoshinobu, Ichimura   +2 more
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SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect

, 2019
Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to the development of OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) has been reported to possess anti-inflammatory effect in ...
Hangang Chen (757731), Lin Chen (54305), Nan Su (323312), Bin Zhang (64682), Zhenhong Ni (722794), Yangli Xie (757725), Junjie Ouyang (1765717), Xiaolan Du (757732), Liang Chen (73736), Qiaoyan Tan (817040)   +9 more
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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

eLife, 2016
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level.
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler   +23 more
doaj   +1 more source