Results 41 to 50 of about 26,505 (243)

SQSTM1/p62 Knockout by Using the CRISPR/Cas9 System Inhibits Migration and Invasion of Hepatocellular Carcinoma

Cells, 2023
Migration and invasion play crucial roles in the progression of hepatocellular carcinoma (HCC), but the underlying mechanisms are not clear. Analysis of clinical samples indicates that SQSTM1/p62 is highly expressed in HCC and seriously affects the ...
Jinghua Lu, Yipei Ding, Wanqiu Zhang, Yuanyuan Qi, Jin Zhou, Naihan Xu, Yaou Zhang, Weidong Xie   +7 more
doaj   +1 more source

AMBRA1 and SQSTM1 expression pattern in prostate cancer [PDF]

Apoptosis, 2015
Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer drugs in prostate cancer cells.
Falasca L., Torino F., Marconi M., Costantini M., Pompeo V., Sentinelli S., De Salvo L., Patrizio M., Padula C., Gallucci M., Piacentini M., Malorni W.   +11 more
openaire   +3 more sources

m6A eraser FTO modulates autophagy by targeting SQSTM1/P62 in the prevention of canagliflozin against renal fibrosis

Frontiers in Immunology, 2023
The dysregulation of autophagy contributes to renal fibrosis. N6-Methyladenosine (m6A) RNA modification is a critical mediator of autophagy. Our previous studies have reported that the disorder of the PPARα/fatty acid oxidation (FAO) axis in renal ...
Youjing Yang, Qianmin Li, Yi Ling, Linxin Leng, Yu Ma, Lian Xue, Guoyuan Lu, Yue Ding, Jianzhong Li, Shasha Tao, Shasha Tao   +10 more
doaj   +1 more source

p62/SQSTM1 at the interface of aging, autophagy, and disease [PDF]

AGE, 2014
Advanced age is characterized by increased incidence of many chronic, noninfectious diseases that impair the quality of living of the elderly and pose a major burden on the healthcare systems of developed countries. These diseases are characterized by impaired or altered function at the tissue and cellular level, which is a hallmark of the aging ...
Alessandro, Bitto, Chad A, Lerner, Timothy, Nacarelli, Elizabeth, Crowe, Claudio, Torres, Christian, Sell   +5 more
openaire   +2 more sources

The PB1 and the ZZ domain of the autophagy receptor p62/SQSTM1 regulate the interaction of p62/SQSTM1 with the autophagosome protein LC3B

Protein Science, 2023
AbstractAutophagy is a highly conserved cellular process that allows degradation of large macromolecules. p62/SQSTM1 is a key adaptor protein that interacts both with material to be degraded and with LC3 at the autophagosome, enabling degradation of cargos such as protein aggregates, lipid droplets and damaged organelles by selective autophagy ...
Alcober‐Boquet, Lucia, Zang, Tabea, Pietsch, Larissa, Suess, Evelyn, Hartmann, Markus, Proschak, Ewgenij, Gross, Lissy Z. F., Sacerdoti, Mariana, Zeuzem, Stefan, Rogov, Vladimir V., Leroux, Alejandro E., Piiper, Albrecht, Biondi, Ricardo M.   +12 more
openaire   +2 more sources

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1. [PDF]

Sci Adv
(Macro)autophagy is a conserved cellular degradation pathway that delivers substrates to lysosomes via autophagosomes. Among various physiological stimuli, nutrient starvation is the most potent inducer of autophagy.
Iavazzo M, Cinque L, Levantovsky S, Morrone C, Monfregola J, Raimondi A, Polishchuk E, De Cegli R, Carrella D, Nusco E, Ferrante L, Sacco F, Frankel LB, Behrends C, Settembre C.   +14 more
europepmc   +2 more sources

Control of SQSTM1 by NOD2.

, 2023
We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of autophagy receptor p62/sequestosome 1 by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire   +1 more source

p62/SQSTM1/A170: Physiology and pathology

Pharmacological Research, 2012
p62/SQSTM1/A170 (hereafter referred to as p62) is a stress-inducible intracellular protein known to regulate various signal transduction pathways involved in cell survival and cell death. Comprehensive analysis of LC3 (an autophagosome localizing protein)-binding proteins resulted in the recognition of autophagy and p62.
Masaaki, Komatsu, Shun, Kageyama, Yoshinobu, Ichimura   +2 more
openaire   +2 more sources

SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B/IL-1β and contributes to LIPUS-mediated anti-inflammatory effect

, 2019
Synovitis is implicated in the pathology of osteoarthritis (OA) and significantly contributes to the development of OA. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) has been reported to possess anti-inflammatory effect in ...
Hangang Chen (757731), Lin Chen (54305), Nan Su (323312), Bin Zhang (64682), Zhenhong Ni (722794), Yangli Xie (757725), Junjie Ouyang (1765717), Xiaolan Du (757732), Liang Chen (73736), Qiaoyan Tan (817040)   +9 more
core   +1 more source