Results 51 to 60 of about 26,505 (243)
The higher-order molecular organization of p62/SQSTM1
Oncotarget, 2015 The multifunctional signaling adaptor and selective autophagy receptor p62/SQSTM1 is commonly found in dense light-microscopic loci of eukaryotic cells. Recently, Ciuffa et al. demonstrated that p62 is able to form organized polymers of helical symmetry once purified and reconstituted in the test tube [1].
Terje, Johansen, Carsten, Sachse
openaire +2 more sources
Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis
, 2022 Acute pancreatitis (AP) is an abdominal inflammatory disease initiated by damaged pancreatic acinar cells and developed by systemic inflammation.
Liangchun Yang (562708) +5 more
core +1 more source
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
eLife, 2016 SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level.
Rowena DeJesus +23 more
doaj +1 more source
Frontiers in Physiology, 2022 Introduction: Obesity is a risk factor for many diseases because it leads to a reduction in skeletal muscle mass and promotes insulin resistance. p62/Sqstm1-knockout mice are a model of metabolic syndrome; show obesity, insulin resistance, and non-alcoholic fatty liver (NAFL); and develop non-alcoholic steatohepatitis (NASH) in response to the feeding ...
Ikuru Miura +8 more
openaire +3 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach +23 more
wiley +1 more source
t(2;5)(p23;q35) SQSTM1/ALK [PDF]
, 2012 Review on t(2;5)(p23;q35) SQSTM1/ALK, with data on clinics, and the genes ...
Huret, JL
core +1 more source