Results 71 to 80 of about 26,505 (243)

p62/SQSTM1 upregulation constitutes a survival mechanism that occurs during granulocytic differentiation of acute myeloid leukemia cells.

, 2014
The p62/SQSTM1 adapter protein has an important role in the regulation of several key signaling pathways and helps transport ubiquitinated proteins to the autophagosomes and proteasome for degradation. Here, we investigate the regulation and roles of p62/
S Souquere, D Brigger, E Ségal-Bendirdjian, Tschan, Mario, P Soubeyran, Reiffers, J., Ségal-Bendirdjian, E, Djavaheri-Mergny, M, M P Tschan, Pierron, G, Schläfli, A, M, Souquere, S, Soubeyran, P., A M Schläfli, Trocoli, A, Soubeyran, P, F Merhi, E Richard, P Bensadoun, Schläfli, A,, Tschan, M.,, Brigger, D, G Labrunie, Pierron, G., Schläfli, Anna, Brigger, Daniel, Pasquet, J-M, Labrunie, G, Reiffers, J, M Djavaheri-Mergny, Richard, E, Djavaheri-Mergny, Mojgan, Merhi, F, G Pierron, Tschan, M., P, Richard, E., Souquere, S., Bensadoun, P, J-M Pasquet, J Reiffers, A Trocoli   +40 more
core   +1 more source

Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage

Toxics, 2023
Mefenamic acid (MFA) is a commonly prescribed non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. MFA is known to have potent antioxidant properties and a neuroprotective effect against oxidative stress. However,
Wonseok Lee, Yewon Mun, Kang-Yo Lee, Jung-Min Park, Tong-Shin Chang, You-Jin Choi, Byung-Hoon Lee   +6 more
doaj   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Mammalian Cell-Free System Recapitulates the Early Events of Post-Fertilization Sperm Mitophagy

Cells, 2021
Propagation of paternal sperm-contributed mitochondrial genes, resulting in heteroplasmy, is seldom observed in mammals due to post-fertilization degradation of sperm mitochondria, referred to as sperm mitophagy.
Won-Hee Song, Dalen Zuidema, Young-Joo Yi, Michal Zigo, Zhibing Zhang, Miriam Sutovsky, Peter Sutovsky   +6 more
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Non-synonymous SQSTM1 mutations.

, 2016
Non-synonymous SQSTM1 mutations.
Young H. Kwon (2824823), Wallace L. M. Alward (387966), Todd E. Scheetz (205742), Frances Solivan-Timpe (2824826), Kathy Miller (2824817), Edwin M. Stone (129407), John H. Fingert (129391), Ben R. Roos (2824814), Adam P. DeLuca (2824820), Kai Wang (21246)   +9 more
core   +1 more source

The Autophagy Machinery Contributes to E-cadherin Turnover in Breast Cancer

Frontiers in Cell and Developmental Biology, 2020
Autophagy is an intracellular catabolic process that is increasingly being recognized as a crucial factor in several human diseases including cancers. Mounting evidence suggests that autophagy allows tumor cells to overcome otherwise fatal stresses and ...
Valentina Damiano, Paola Spessotto, Giulia Vanin, Tiziana Perin, Roberta Maestro, Manuela Santarosa   +5 more
doaj   +1 more source

SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. [PDF]

PLoS ONE, 2014
Organisms exposed to oxidative stress respond by orchestrating a stress response to prevent further damage. Intracellular levels of antioxidant agents increase, and damaged components are removed by autophagy induction.
Sagar Ramesh Darvekar, Julianne Elvenes, Hanne Britt Brenne, Terje Johansen, Eva Sjøttem   +4 more
doaj   +1 more source

pH-dependent regulation of SQSTM1/p62 during autophagy [PDF]

Autophagy, 2018
During macroautophagy/autophagy, SQSTM1/p62 plays dual roles as a key mediator of cargo selection and as an autophagic substrate. SQSTM1 links N-degrons and/or ubiquitinated cargoes to the autophagosome by forming homo- or hetero-oligomers, although its N-degron recognition and oligomerization mechanisms are not well characterized.
Do Hoon Kwon, Leehyeon Kim, Hyun Kyu Song   +2 more
openaire   +2 more sources

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source