Results 81 to 90 of about 28,326 (246)

A phenotype of atypical apraxia of speech in a family carrying SQSTM1 mutation. [PDF]

, 2014
SQSTM1 mutations, coding for the p62 protein, were identified as a monogenic cause of Paget disease of bone and of amyotrophic lateral sclerosis. More recently, SQSTM1 mutations were identified in few families with frontotemporal dementia.
Isabelle Le Ber, Vercelletto, Martine, Derkinderen, P, Rita Guerreiro, Claire Boutoleau-Bretonnière, Martine Vercelletto, Hardy, John, Le Ber, Isabelle, Christelle Evrard, Pallardy, Amandine, Elisabeth Auffray-Calvier, Kawtar Bouya-Ahmed, John Hardy, Guerreiro, R, Auffray-Calvier, E, Hardy, J, Camuzat, Agnès, Derkinderen, Pascal, Bouya-Ahmed, K, Bras, J, Camuzat, A, Vercelletto, M, Estelle Lamy, Evrard, C, Deruet, AL, Lamy, Estelle, Lamy, E, Amandine Pallardy, Agnès Camuzat, Brice, Alexis, Bouya-Ahmed, Kawtar, Boutoleau-Bretonnière, Claire, Auffray-Calvier, Elisabeth, Brice, A, Guerreiro, Rita, Pallardy, A, Anne-Laure Deruet, Evrard, Christelle, Bras, José, José Bras, Pascal Derkinderen, Boutoleau-Bretonnière, C, Deruet, Anne-Laure, Alexis Brice, Le Ber, I   +44 more
core   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

The higher-order molecular organization of p62/SQSTM1

Oncotarget, 2015
The multifunctional signaling adaptor and selective autophagy receptor p62/SQSTM1 is commonly found in dense light-microscopic loci of eukaryotic cells. Recently, Ciuffa et al. demonstrated that p62 is able to form organized polymers of helical symmetry once purified and reconstituted in the test tube [1].
Terje, Johansen, Carsten, Sachse
openaire   +2 more sources

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12

iScience, 2020
Summary: Mitochondrial DNA (mtDNA) encodes thirteen core components of OXPHOS complexes, and its steady expression is crucial for cellular energy homeostasis.
Yuan Ma, Suwei Zhu, Tingting Lv, Xia Gu, Hong Feng, Junhui Zhen, Wei Xin, Qiang Wan   +7 more
doaj   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate [PDF]

Journal of Cell Science, 2011
Proteolytic systems and the aggresome pathway contribute to preventing accumulation of cytotoxic aggregation-prone proteins. Although polyubiquitylation is usually required for degradation or aggresome formation, several substrates are processed independently of ubiquitin through a poorly understood mechanism.
Yoshihisa, Watanabe, Masaki, Tanaka
openaire   +2 more sources

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

SQSTM1/p62 as a prognostic indicator in pancancer and nasopharyngeal carcinoma

BMC Research Notes
Objective This study evaluated SQSTM1/p62 expression patterns and its prognostic value across multiple cancers, with a focus on nasopharyngeal carcinoma (NPC).
Li-li Chen, Zong-yao Zhang, Bo Wu, Mei-zhen Lu   +3 more
doaj   +1 more source

Autophagy regulates DNA repair through SQSTM1/p62 [PDF]

Autophagy, 2017
Macroautophagy/autophagy is primarily a degradative pathway that clears malfunctioning cellular components in response to various types of stress. Recent studies have indicated that autophagy also plays an important role in maintaining genome stability. Loss of autophagy is associated with increased damage to DNA, inappropriate amplification of genomic
Yuchen Feng, Daniel J. Klionsky
openaire   +2 more sources