Results 81 to 90 of about 26,505 (243)

Colocalization of SQSTM1/p62 and MAP1LC3A/LC3 and position changes of SQSTM1/p62, revealed by confocal microscopy analysis.

, 2013
A light merge orange/yellow signal of colocalizing MAP1LC3A/LC3 (pDendra2-hLC3, green) and SQSTM1/p62 (pDsRed2-hp62, red) is detectable, usually near to the cell nuclei. Nuclei are stained with blue dye. The scale bar equals to 5 µm.
Nicoletta Marchesi (438940), Niko Kivinen (438942), Stefano Govoni (188486), Marialaura Amadio (438939), Reijo Sironen (438943), Vito Giuseppe D'Agostino (438946), Alessandro Provenzani (438945), Goran Petrovski (129836), Alessia Pascale (438947), Saeed Akhtar (95771), Antero Salminen (438949), Juha M. T. Hyttinen (438941), Hansjurgen Agostini (438948), Kai Kaarniranta (187693), Johanna Viiri (438938), Kirsi Rilla (438944)   +15 more
core   +1 more source

A phenotype of atypical apraxia of speech in a family carrying SQSTM1 mutation. [PDF]

, 2014
SQSTM1 mutations, coding for the p62 protein, were identified as a monogenic cause of Paget disease of bone and of amyotrophic lateral sclerosis. More recently, SQSTM1 mutations were identified in few families with frontotemporal dementia.
Isabelle Le Ber, Vercelletto, Martine, Derkinderen, P, Rita Guerreiro, Claire Boutoleau-Bretonnière, Martine Vercelletto, Hardy, John, Le Ber, Isabelle, Christelle Evrard, Pallardy, Amandine, Elisabeth Auffray-Calvier, Kawtar Bouya-Ahmed, John Hardy, Guerreiro, R, Auffray-Calvier, E, Hardy, J, Camuzat, Agnès, Derkinderen, Pascal, Bouya-Ahmed, K, Bras, J, Camuzat, A, Vercelletto, M, Estelle Lamy, Evrard, C, Deruet, AL, Lamy, Estelle, Lamy, E, Amandine Pallardy, Agnès Camuzat, Brice, Alexis, Bouya-Ahmed, Kawtar, Boutoleau-Bretonnière, Claire, Auffray-Calvier, Elisabeth, Brice, A, Guerreiro, Rita, Pallardy, A, Anne-Laure Deruet, Evrard, Christelle, Bras, José, José Bras, Pascal Derkinderen, Boutoleau-Bretonnière, C, Deruet, Anne-Laure, Alexis Brice, Le Ber, I   +44 more
core   +1 more source

p62/SQSTM1 – steering the cell through health and disease [PDF]

Journal of Cell Science, 2018
ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold protein involved in diverse cellular processes. Its functions are tightly regulated through an extensive pattern of post-translational modifications, and include the isolation of cargos degraded by autophagy, induction of the antioxidant response by the ...
Pablo Sánchez-Martín, Masaaki Komatsu
openaire   +2 more sources

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12

iScience, 2020
Summary: Mitochondrial DNA (mtDNA) encodes thirteen core components of OXPHOS complexes, and its steady expression is crucial for cellular energy homeostasis.
Yuan Ma, Suwei Zhu, Tingting Lv, Xia Gu, Hong Feng, Junhui Zhen, Wei Xin, Qiang Wan   +7 more
doaj   +1 more source

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate [PDF]

Journal of Cell Science, 2011
Proteolytic systems and the aggresome pathway contribute to preventing accumulation of cytotoxic aggregation-prone proteins. Although polyubiquitylation is usually required for degradation or aggresome formation, several substrates are processed independently of ubiquitin through a poorly understood mechanism.
Yoshihisa, Watanabe, Masaki, Tanaka
openaire   +2 more sources

Primary Pulmonary Epithelioid Inflammatory Myofibroblastic Sarcoma With SQSTM1::ALK Fusion

Diagnostic Cytopathology, EarlyView.
ABSTRACT Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive variant of inflammatory myofibroblastic tumor (IMT) characterized by epithelioid morphology, atypical features, ALK rearrangements, and early metastatic potential.
Havva Gokce Terzioglu, Phillip McMullen, Güliz A. Barkan   +2 more
wiley   +1 more source

BCR-ABL/p62/SQSTM1: a cannibal embrace [PDF]

Blood, 2012
In this issue of Blood, Goussetis et al identify autophagy as a new pathway for the degradation of the oncoprotein BCR-ABL. They show that the therapeutic drug arsenic trioxide (AS(2)O(3)) targets BCR-ABL for autophagic degradation via a p62/SQSTM1-dependent mechanism that is critical for the antileukemic effect of the drug.
openaire   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62 [PDF]

Oncogene, 2008
Sequestosome 1 (SQSTM1/p62) is a multifunctional protein involved in signal transduction, protein degradation and cell transformation. Hypoxia is a common feature of solid tumours that promotes cancer progression. Here, we report that p62 is downregulated in hypoxia in carcinoma cells and that the expression is rapidly restored in response to ...
J-P, Pursiheimo, K, Rantanen, P T, Heikkinen, T, Johansen, P M, Jaakkola   +4 more
openaire   +2 more sources