Results 61 to 70 of about 28,326 (246)

t(2;5)(p23;q35) SQSTM1/ALK [PDF]

, 2012
Review on t(2;5)(p23;q35) SQSTM1/ALK, with data on clinics, and the genes ...
Huret, JL
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Plasma SQSTM1/p62 act as a biomarker for steroid-induced osteonecrosis of the femoral head

Scientific Reports
Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity.
Wenyuan Hou, Peng Peng, Fangjun Xiao, Jiaqing Tian, Xianshun He, Shun Lu, Huan Xiao, Mincong He, Qiushi Wei   +8 more
doaj   +1 more source

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. [PDF]

PLoS ONE, 2013
Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells (RPE) causes secondarily adverse effects on neural retina leading to ...
Johanna Viiri, Marialaura Amadio, Nicoletta Marchesi, Juha M T Hyttinen, Niko Kivinen, Reijo Sironen, Kirsi Rilla, Saeed Akhtar, Alessandro Provenzani, Vito Giuseppe D'Agostino, Stefano Govoni, Alessia Pascale, Hansjurgen Agostini, Goran Petrovski, Antero Salminen, Kai Kaarniranta   +15 more
doaj   +1 more source

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis [PDF]

, 2012
Objective: There is increasing evidence that common genetic risk factors underlie frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).
S. Gentile, S. Gallone, P. St George Hyslop, E. Scarpini, Isaia, Giovanni Carlo, A. Chiò, L. Pinessi, P. Fenoglio, Calvo, Andrea, A. C. Bruni, Chio', Adriano, I. Rainero, A. Calvo, A. Bruni, G. Isaia, Y. Grinberg, Rainero, Innocenzo, P. H. St George Hyslop, E. Rubino, D. Galimberti, Rubino, Elisa, E. Rogaeva, Pinessi, Lorenzo   +22 more
core   +1 more source

O‐GlcNAcylation Regulation of SNAP29‐Dependent Autophagy Activation Dictates Chemoresistance in Gastric Cancer

Advanced Science, EarlyView.
Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang, Shaoji Zhao, Ziling Shao, Tao Luo, Baifu Peng, Yifan Liu, Jinning Ye, Jianjun Peng, Kaiyu Sun, Jianbo Xu   +9 more
wiley   +1 more source

Autophagy regulates rRNA synthesis

Nucleus, 2022
Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj   +1 more source

Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. [PDF]

, 2016
新潟大学博士（医学）Sqstm1 serves as a signaling hub and receptor for selective autophagy. Consequently, dysregulation of Sqstm1 causes imbalances in signaling pathways and disrupts proteostasis, thereby contributing to the development of human diseases ...
Eino, Atsushi, 50775
core  

Non-synonymous SQSTM1 mutations.

, 2016
Non-synonymous SQSTM1 mutations.
Young H. Kwon (2824823), Wallace L. M. Alward (387966), Todd E. Scheetz (205742), Frances Solivan-Timpe (2824826), Kathy Miller (2824817), Edwin M. Stone (129407), John H. Fingert (129391), Ben R. Roos (2824814), Adam P. DeLuca (2824820), Kai Wang (21246)   +9 more
core   +1 more source