Results 31 to 40 of about 26,505 (243)

Role of p62/SQSTM1 in liver physiology and pathogenesis [PDF]

Experimental Biology and Medicine, 2013
p62/sequestosome-1/A170/ZIP (hereafter referred to as p62) is a scaffold protein that has multiple functions, such as signal transduction, cell proliferation, cell survival, cell death, inflammation, tumourigenesis and oxidative stress response. While p62 is an autophagy substrate and is degraded by autophagy, p62 serves as an autophagy receptor for ...
Sharon, Manley, Jessica A, Williams, Wen-Xing, Ding   +2 more
openaire   +2 more sources

Systemic overexpression of SQSTM1/p62 accelerates disease onset in a SOD1H46R-expressing ALS mouse model

Molecular Brain, 2018
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons. Recent studies have shown that mutations in SQSTM1 are linked to ALS.
Shun Mitsui, Asako Otomo, Masahisa Nozaki, Suzuka Ono, Kai Sato, Ryohei Shirakawa, Hiroaki Adachi, Masashi Aoki, Gen Sobue, Hui-Fang Shang, Shinji Hadano   +10 more
doaj   +1 more source

ZZ-dependent regulation of p62/SQSTM1 in autophagy [PDF]

Nature Communications, 2018
AbstractAutophagic receptor p62 is a critical mediator of cell detoxification, stress response, and metabolic programs and is commonly deregulated in human diseases. The diverse functions of p62 arise from its ability to interact with a large set of ligands, such as arginylated (Nt-R) substrates. Here, we describe the structural mechanism for selective
Yi Zhang, Su Ran Mun, Juan F. Linares, JaeWoo Ahn, Christina G. Towers, Chang Hoon Ji, Brent E. Fitzwalter, Michael R. Holden, Wenyi Mi, Xiaobing Shi, Jorge Moscat, Andrew Thorburn, Maria T. Diaz-Meco, Yong Tae Kwon, Tatiana G. Kutateladze   +14 more
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Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]

, 2011
Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka, Jolanta Łukomska, Surowiecki, Przemysław, Agnieszka Sirko, Lewandowska, Małgorzata, Liszewska, Frantz, Małgorzata Lewandowska, Anna Wawrzyńska, Grzegorz Moniuszko, Łukomska, Jolanta, Frantz Liszewska, Moniuszko, Grzegorz, Wawrzyńska, Anna, Gwozdecki, Rafał, Katarzyna Zientara-Rytter, Rafał Gwozdecki, Przemysław Surowiecki, Zientara-Rytter, Katarzyna   +17 more
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Combined Evaluation of MAP1LC3B and SQSTM1 for Biological and Clinical Significance in Ductal Carcinoma of Breast Cancer

Biomedicines, 2021
Breast cancer is the leading cause of cancer death in women worldwide. The microtubule-associated protein light chain 3B (MAP1LC3B) and adaptor sequestosome 1 (SQSTM1) are two major markers for autophagy.
Pei-Feng Liu, Chih-Wen Shu, Hsiu-Chen Yang, Cheng-Hsin Lee, Huei-Han Liou, Luo-Ping Ger, Yen-Dun Tony Tzeng, Wen-Ching Wang   +7 more
doaj   +1 more source

Selective turnover of p62/A170/SQSTM1 by autophagy [PDF]

Autophagy, 2008
Loss of autophagy causes liver injury, cardiomyopathy and neurodegeneration, associated with the formation of ubiquitin-positive inclusion bodies. However, the pathogenic mechanism and molecular machinery involved in inclusion formation are not fully understood. We recently identified a ubiquitin-binding protein, p62/A170/SQSTM1, as a molecule involved
Yoshinobu, Ichimura, Eiki, Kominami, Keiji, Tanaka, Masaaki, Komatsu   +3 more
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Identification of a Novel Hemizygous SQSTM1 Nonsense Mutation in Atypical Behavioral Variant Frontotemporal Dementia

Frontiers in Aging Neuroscience, 2018
Frontotemporal dementia includes a large spectrum of neurodegenerative disorders. SQSTM1, coding for p62 protein, plays a vital role in the pathogenesis of FTD.
Lin Sun, Zhouyi Rong, Wei Li, Honghua Zheng, Honghua Zheng, Shifu Xiao, Xia Li   +6 more
doaj   +1 more source

Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background: Alcohol-associated liver disease (ALD) is a worldwide health problem, of which the effective treatment is still lacking. Both detrimental and protective roles of adipose tissue have been implicated in ALD.
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Rülicke, Kurt Zatloukal, Hong-Min Ni, Wen-Xing Ding   +9 more
doaj   +1 more source

SQSTM1/p62: A Potential Target for Neurodegenerative Disease [PDF]

ACS Chemical Neuroscience, 2019
Neurodegenerative diseases, characterized by a progressive loss of brain function, affect the lives of millions of individuals worldwide. The complexity of the brain poses a challenge for scientists trying to map the biochemical and physiological pathways to identify areas of pathological errors.
Shifan Ma, Insiya Y. Attarwala, Xiang-Qun Xie   +2 more
openaire   +2 more sources

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of the bone) : a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventative treatment if they were available [PDF]

, 2008
Background: Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
Ralston, Stuart H., Charnock Keith, Campbell, MK, Graeme MacLennan, John Weinman, McCallum Marilyn, Robertson, C., Weinman, John, Miedzybrodska Zosia, Langston Anne L, Weinman John, Vikki A Entwistle, Campbell, Marion K, McCallum, M., Robertson Clare, Entwistle, V.A, Campbell, Marion K., Francis, J., Charnock, K., Ralston, Stuart H, Langston, A. L., Robertson, Clare, MacLennan, Graeme Stewart, Entwistle Vikki A, Campbell, M K, Langston, AL, Francis, Jillian Joy, Marteau Theresa, Zosia Miedzybrodska, Miedzybrodska, Z, Langston, Anne L, Entwistle, Vikki A., Marilyn McCallum, Langston, A L, Entwistle, Vikki, Ralston, SH, Campbell, Marion Kay, Anne L Langston, Jill Francis, Ralston, S H, Miedzybrodzka, Zosia, Marie Johnston, Charnock, Keith, Francis, Jill, Weinman, J, Ralston, S.H, Weinman, J., Langston, A.L, Robertson, C, Entwistle, V A, Clare Robertson, McCallum, Marilyn, Ralston, S., Johnston Marie, Marteau, T, Campbell Marion K, Miedzybrodzka, Z., Entwistle, Vikki A, Campbell, M.K, Theresa Marteau, Johnston, M, Stuart H Ralston, Langston, Anne L., Entwistle, V., Johnston, M., Francis Jill, Ralston Stuart H, MacLennan, G, Campbell, M. K., Marteau, T., Entwistle, VA, Johnston, Marie, Marion K Campbell, Maclennan, Graeme, Miedzybrodska, Zosia, McCallum, M, MacLennan Graeme, Keith Charnock, Francis, J, Charnock, K, Marteau, Theresa, MacLennan, G.   +81 more
core   +1 more source