Sequestosome 1 Is Part of the Interaction Network of VAPB [PDF]
International Journal of Molecular Sciences, 2021 VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at the inner nuclear membrane. As a component of many contact sites between the endoplasmic reticulum and other organelles, VAPB is engaged in multiple protein interactions with a plethora of binding
Christina James +2 more
exaly +11 more sources
p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies. [PDF]
PLoS ONE, 2016 Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestosome-1
Pooja Lahiri +8 more
doaj +6 more sources
TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1
Molecular Immunology, 2014 The atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated in the activation of NF-κB in TNFα-stimulated cells and has been shown to be activated in response to interleukin-1β (IL-1β). Here
Tiziana Zotti +2 more
exaly +7 more sources
Sequestosome 1/p62 enhances chronic skin inflammation [PDF]
Journal of Allergy and Clinical Immunology, 2021 The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling.We sought to determine ...
Supawadee Sukseree +2 more
exaly +4 more sources
Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas [PDF]
Analytical Cellular PathologyAmong autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases ...
Antonio Ieni +8 more
doaj +3 more sources
Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [PDF]
Autophagy ReportsProtein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
doaj +4 more sources
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis [PDF]
Cell Death and DiseaseAlterations in the dopamine catabolic pathway are known to contribute to the degeneration of nigrostriatal neurons in Parkinson’s disease (PD). The progressive cellular buildup of the highly reactive intermediate 3,4-dihydroxyphenylacetaldehye (DOPAL ...
Anna Masato +9 more
doaj +5 more sources
The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved] [PDF]
F1000Research, 2023 Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways.
Peter S. McPherson +5 more
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Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review). [PDF]
Int J Oncol, 2021 Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin‑proteasome degradation pathway. Numerous studies have shown that SQSTM1/p62 functions at multiple levels, including involvement in genetic stability or ...
Tang J +6 more
europepmc +4 more sources
Alterations of the 70 kDa heat shock protein (HSP70) and sequestosome-1 (p62) in women with breast cancer [PDF]
Scientific Reports, 2021 Peripheral blood mononuclear cells (PBMCs) respond to altered physiological conditions to alleviate the threat. Production of the 70 kDa heat shock protein (HSP70) is up-regulated to protect proteins from degradation.
Theofano Orfanelli +12 more
doaj +2 more sources