Results 31 to 40 of about 57,370,564 (168)

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of the bone) : a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventative treatment if they were available [PDF]

, 2008
Background: Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
Ralston, Stuart H., Charnock Keith, Campbell, MK, Graeme MacLennan, John Weinman, McCallum Marilyn, Robertson, C., Weinman, John, Miedzybrodska Zosia, Langston Anne L, Weinman John, Vikki A Entwistle, Campbell, Marion K, McCallum, M., Robertson Clare, Entwistle, V.A, Campbell, Marion K., Francis, J., Charnock, K., Ralston, Stuart H, Langston, A. L., Robertson, Clare, MacLennan, Graeme Stewart, Entwistle Vikki A, Campbell, M K, Langston, AL, Francis, Jillian Joy, Marteau Theresa, Zosia Miedzybrodska, Miedzybrodska, Z, Langston, Anne L, Entwistle, Vikki A., Marilyn McCallum, Langston, A L, Entwistle, Vikki, Ralston, SH, Campbell, Marion Kay, Anne L Langston, Jill Francis, Ralston, S H, Miedzybrodzka, Zosia, Marie Johnston, Charnock, Keith, Francis, Jill, Weinman, J, Ralston, S.H, Weinman, J., Langston, A.L, Robertson, C, Entwistle, V A, Clare Robertson, McCallum, Marilyn, Ralston, S., Johnston Marie, Marteau, T, Campbell Marion K, Miedzybrodzka, Z., Entwistle, Vikki A, Campbell, M.K, Theresa Marteau, Johnston, M, Stuart H Ralston, Langston, Anne L., Entwistle, V., Johnston, M., Francis Jill, Ralston Stuart H, MacLennan, G, Campbell, M. K., Marteau, T., Entwistle, VA, Johnston, Marie, Marion K Campbell, Maclennan, Graeme, Miedzybrodska, Zosia, McCallum, M, MacLennan Graeme, Keith Charnock, Francis, J, Charnock, K, Marteau, Theresa, MacLennan, G.   +81 more
core   +2 more sources

The role of autophagy related signal transduction pathways in bone metabolism [PDF]

Yixue xinzhi zazhi, 2022
Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation.
Zhi-Zhuo LI, Li-Jun SHI, Fu-Qiang GAO, Wei SUN   +3 more
doaj   +1 more source

Antibody Characterization Report for Sequestosome-1

, 2021
were performed with large 4-15% gradient polyacrylamide gels and transferred on nitrocellulose membranes. Proteins on the blots were visualized with Ponceau staining which is scanned to show together with individual immunoblot. Blots were blocked with 5%
R. Ayoubi, Walaa Alshafie, I. Shlaifer, T. Durcan, P. McPherson, C. Laflamme   +5 more
semanticscholar   +1 more source

Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts [PDF]

, 2010
Peer ...
Hocking, Lynne J., Rogers, Michael J., Paul S. McCabe, Miep H. Helfrich, David J. Mellis, Mellis, David J., Lynne J. Hocking, Michael J. Rogers, Helfrich, Miep H., McCabe, Paul S.   +9 more
core   +1 more source

Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. [PDF]

PLoS ONE, 2012
The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer ...
Chuanwen Lu, Changxia Shao, Everardo Cobos, Kamaleshwar P Singh, Weimin Gao   +4 more
doaj   +1 more source

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases.

Journal of Neuropathology and Experimental Neurology, 2020
Human neurodegenerative diseases can be characterized as disorders of protein aggregation. As a key player in cellular autophagy and the ubiquitin proteasome system, p62 may represent an effective immunohistochemical target, as well as mechanistic ...
Jorge A. Trejo-Lopez, Z. Sorrentino, Cara J. Riffe, S. Prokop, D. Dickson, A. Yachnis, B. Giasson   +6 more
semanticscholar   +1 more source

The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved]

F1000Research
Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways.
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Walaa Alshafie, Irina Shlaifer   +5 more
doaj   +1 more source

1Ceramide synthase 6 induces mitochondrial dysfunction and apoptosis in hemin-treated neurons by impairing mitophagy through interacting with sequestosome 1.

Free Radical Biology & Medicine
Intracerebral hemorrhage (ICH) is a severe subtype of stroke linked to high morbidity and mortality rates. However, the underlying mechanisms of neuronal injury post-ICH remain poorly understood.
Ao-Qian Xu, Yi-Kui Liu, Bao-Feng Wang, Qi-Xiang Zhang, Yu-Xiao Ma, Yu-Xiao Xue, Zhuo-Hang Wang, Qing-Fang Sun, Yu-Hao Sun, Liu-Guan Bian   +9 more
semanticscholar   +1 more source

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj   +1 more source

Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2

Cardiovascular Research
Aims Heart failure due to ischaemic heart disease (IHD) is a leading cause of mortality worldwide. A major contributing factor to IHD-induced cardiac damage is hypoxia.
Rajeshwary Ghosh, A. N. Fatahian, Omid Rouzbehani, Marissa A. Hathaway, Tariq Mosleh, Vishak Vinod, Sidney Vowles, Sophie L Stephens, Siu-Lai Desmond Chung, Isaac D Cao, Anila Jonnavithula, J. D. Symons, S. Boudina   +12 more
semanticscholar   +1 more source