Results 31 to 40 of about 21,246,065 (185)
A proximity-dependent biotinylation (BioID) approach flags the p62/sequestosome-1 protein as a caspase-1 substrate. [PDF]
J Biol Chem, 2018 International audienceThe inflammasome is a major component of the innate immune system, and its main function is to activate caspase-1, a cysteine protease that promotes inflammation by inducing interleukin-1β (IL-1β) maturation and release into the ...
Jamilloux Y +7 more
europepmc +2 more sources
Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages. [PDF]
Infect Immun, 2018 Coxiella burnetii is the causative agent of human Q fever, a debilitating flu-like illness that can progress to chronic disease presenting as endocarditis. Following inhalation, C.
Winchell CG +5 more
europepmc +2 more sources
HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection
Viruses, 2022 Human papillomaviruses (HPVs) inflict a significant burden on the human population. The clinical manifestations caused by high-risk HPV types are cancers at anogenital sites, including cervical cancer, as well as head and neck cancers.
Linda Schweiger +7 more
doaj +1 more source
Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging
Frontiers in Cell and Developmental Biology, 2022 Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V. Kumar +2 more
doaj +1 more source
p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine. [PDF]
Int J Mol Sci, 2014 The cellular protein quality control system in association with aggresome formation contributes to protecting cells against aggregation-prone protein-induced toxicity. p62/Sequestosome 1 (p62) is a multifunctional protein which plays an important role in
Zhou L +5 more
europepmc +2 more sources
p62 Overexpression Promotes Bone Metastasis of Lung Adenocarcinoma out of LC3-Dependent Autophagy
Frontiers in Oncology, 2021 p62 protein has been implicated in bone metastasis and is a multifunctional adaptor protein usually correlated with autophagy. Herein, we investigated p62 expression and its prognostic significance in bone metastasis of lung adenocarcinoma, and analyzed ...
Dongqi Li +6 more
doaj +1 more source
Scientific Reports, 2022 The aetiology of Amyotrophic Lateral Sclerosis (ALS) is still poorly understood. The discovery of genetic forms of ALS pointed out the mechanisms underlying this pathology, but also showed how complex these mechanisms are.
Giovanni De Marco +12 more
doaj +1 more source
Cancer Reports, 2023 Background Inflammatory myofibroblastic tumor (IMT) is an ultra‐rare soft tissue neoplasm associated with fusion proteins encompassing the anaplastic lymphoma kinase (ALK) protein fused to a variety of partner proteins.
Cass G. G. Sunga +4 more
doaj +1 more source
Autophagy regulates rRNA synthesis
Nucleus, 2022 Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj +1 more source
p62/Sequestosome-1 Up-regulation Promotes ABT-263-induced Caspase-8 Aggregation/Activation on the Autophagosome [PDF]
Journal of Biological Chemistry, 2013 Shengbing Huang +2 more
exaly +2 more sources