Results 51 to 60 of about 21,246,065 (185)

Chemotherapeutic sensitization of leptomycin B resistant lung cancer cells by pretreatment with doxorubicin. [PDF]

PLoS ONE, 2012
The development of novel targeted therapies has become an important research focus for lung cancer treatment. Our previous study has shown leptomycin B (LMB) significantly inhibited proliferation of lung cancer cells; however, p53 wild type lung cancer ...
Chuanwen Lu, Changxia Shao, Everardo Cobos, Kamaleshwar P Singh, Weimin Gao   +4 more
doaj   +1 more source

P62 Sequestosome 1/Light Chain 3b Complex Confers Cytoprotection on Lung Epithelial Cells After Hyperoxia

, 2020
Lung epithelial cell death is a prominent feature of hyperoxic lung injury, and has been considered a very important underlying mechanism of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).
Fung, James, Wei, Shu-Quan, Tanaka, Akihiko, Choi, Augustine, Jin, Yang, Liang, Xiaoliang, Lee, Seon-Jin, Zhang, Meng   +7 more
core   +2 more sources

Clinical and Cellular Phenotypes Associated With Sequestosome 1 (SQSTM1) Mutations [PDF]

Journal of Bone and Mineral Research, 2006
Abstract Familial Paget's disease of bone has been shown to be associated with mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 (SQSTM1) gene. We have clinical findings on five families with diverse racial and ethnic backgrounds who all harbor SQSTM1 UBA domain mutations (P387L, P392L, D391fsX394, P392fsX394 ...
Robin J, Leach, Frederick R, Singer, Yasmin, Ench, Julie H, Wisdom, Diana S, Pina, Teresa L, Johnson-Pais   +5 more
openaire   +2 more sources

Effect of colony‐stimulating factor‐1 receptor overexpression on the growth of nasopharyngeal carcinoma xenografts in nude mice and its mechanism of action

Precision Radiation Oncology, 2020
Objectives Although nasopharyngeal carcinoma (NPC) is sensitive to radiotherapy, local recurrence and distant metastasis still occur in a proportion of patients due to radioresistance.
Zenan Chen, Yanrong Hao
doaj   +1 more source

The converging roles of sequestosome-1/p62 in the molecular pathways of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)

Neurobiology of Disease, 2022
Investigations into the pathogenetic mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease.
Jennilee M. Davidson, Roger S. Chung, Albert Lee   +2 more
doaj   +1 more source

Canine distemper virus induces human osteoclastogenesis through NF-κB and sequestosome 1/P62 activation

, 2006
Previous studies have implicated CDV in the pathogenesis of Paget's disease; however, there has been no direct evidence that CDV can infect human cells. We studied the effects of CDV on osteoclastogenesis in vitro and showed that CDV had a dose-dependent
Selby, Peter L., Davies, Michael, Michael Davies, Mee, Andrew P., Andrew P Mee, Peter L Selby   +5 more
core   +1 more source

p62/Sequestosome 1 levels increase and phosphorylation is altered in Cx50D47A lenses, but deletion of p62/sequestosome 1 does not improve transparency.

Molecular vision, 2021
p62/Sequestosome 1 (p62) is a stress-induced protein that is involved in several different intracellular pathways, including regulation of aspects of protein degradation. p62 levels are elevated in several types of cataracts. We investigated whether levels of p62 and its phosphorylation were altered in the lenses of Cx50D47A mice, which express a ...
Oscar, Jara, Hubert, Mysliwiec, Peter J, Minogue, Viviana M, Berthoud, Eric C, Beyer   +4 more
openaire   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Prophylactic zoledronic acid therapy to prevent or modify Paget’s disease of bone progression in adults with SQSTM1 mutations: the ZiPP RCT

Efficacy and Mechanism Evaluation
Background Paget’s disease of bone is characterised by focal abnormalities of bone turnover resulting in various complications. It often presents at an advanced stage with irreversible bone damage. At this point, the symptomatic benefits of treatment are
Jonathan Phillips, Deepak Subedi, Steff C Lewis, Catriona Keerie, Stuart H Ralston   +4 more
doaj   +1 more source

Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins [PDF]

Journal of Biological Chemistry, 2008
Sequestosome 1 (SQSTM1)/p62 is an interacting partner of the atypical protein kinase C zeta/iota and serves as a scaffold for cell signaling and ubiquitin binding, which is critical for several cell functions in vivo such as osteoclastogenesis, adipogenesis, and T cell activation.
Marie W, Wooten, Thangiah, Geetha, J Ramesh, Babu, M Lamar, Seibenhener, Junmin, Peng, Nancy, Cox, Maria-T, Diaz-Meco, Jorge, Moscat   +7 more
openaire   +2 more sources