Results 41 to 50 of about 21,246,065 (185)

Antibody Characterization Report for Sequestosome-1

, 2021
A peer-reviewed antibody characterization article corresponding to this Zenodo preprint is openly available at F1000Research: https://doi.org/10.12688/f1000research.132628.1 This report presents a guide to selecting high-quality commercial antibodies against Sequestosome-1 by immunoblot (Western blot), immunoprecipitation and immunofluorescence using ...
Ayoubi, Riham, Alshafie, Walaa, Shlaifer, Irina, Durcan, Thomas M., McPherson, Peter S., Laflamme, Carl   +5 more
openaire   +2 more sources

Dataset for the Sequestosome-1 antibody screening study

, 2023
This project contains the following underlying data included in a study aiming at characterizing antibodies for the Sequestosome-1 protein. The study is available on Zenodo (https://doi.org/10.5281/zenodo.4818440)
Laflamme, Carl
core   +1 more source

Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice [PDF]

Journal of Biological Chemistry, 2016
Hua Yang, Hong-Min Ni, Ying-Hong Shi
exaly   +2 more sources

Nonhistone Lysine Methylation as a Protein Degradation Signal

Journal of Chemistry, 2022
Protein degradation is a fundamental feature of cellular life, and malfunction of this process is implicated in human disease. Ubiquitin tagging is the best characterized mechanism of targeting a protein for degradation; however, there are a growing ...
Nicholas A. Lehning, Brad E. Morrison
doaj   +1 more source

Sequestosome 1/p62, a Scaffolding Protein, Is a Newly Identified Partner of IRS-1 Protein [PDF]

Journal of Biological Chemistry, 2012
Thangiah Geetha, Chen Zheng, Tom L Broderick   +2 more
exaly   +2 more sources

The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou, Yuhao Zhou, Shucheng Hua, Shucheng Hua, Lei Song, Lei Song   +5 more
doaj   +1 more source

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

Molecular & Cellular Oncology, 2021
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu   +2 more
doaj   +1 more source

The role of autophagy related signal transduction pathways in bone metabolism [PDF]

Yixue xinzhi zazhi, 2022
Autophagy is an effective protective mechanism against tissue degeneration and plays an important role in cell proliferation, differentiation and maturation.
Zhi-Zhuo LI, Li-Jun SHI, Fu-Qiang GAO, Wei SUN   +3 more
doaj   +1 more source

Protocol for stage 2 of the GaP study (genetic testing acceptability for Paget's disease of the bone) : a questionnaire study to investigate whether relatives of people with Paget's disease would accept genetic testing and preventative treatment if they were available [PDF]

, 2008
Background: Paget's disease of bone (PDB) disrupts normal bone architecture and causes pain, deformity, deafness, osteoarthritis, and fractures. Genetic factors play a role in PDB and genetic tests are now conducted for research purposes.
Ralston, Stuart H., Charnock Keith, Campbell, MK, Graeme MacLennan, John Weinman, McCallum Marilyn, Robertson, C., Weinman, John, Miedzybrodska Zosia, Langston Anne L, Weinman John, Vikki A Entwistle, Campbell, Marion K, McCallum, M., Robertson Clare, Entwistle, V.A, Campbell, Marion K., Francis, J., Charnock, K., Ralston, Stuart H, Langston, A. L., Robertson, Clare, MacLennan, Graeme Stewart, Entwistle Vikki A, Campbell, M K, Langston, AL, Francis, Jillian Joy, Marteau Theresa, Zosia Miedzybrodska, Miedzybrodska, Z, Langston, Anne L, Entwistle, Vikki A., Marilyn McCallum, Langston, A L, Entwistle, Vikki, Ralston, SH, Campbell, Marion Kay, Anne L Langston, Jill Francis, Ralston, S H, Miedzybrodzka, Zosia, Marie Johnston, Charnock, Keith, Francis, Jill, Weinman, J, Ralston, S.H, Weinman, J., Langston, A.L, Robertson, C, Entwistle, V A, Clare Robertson, McCallum, Marilyn, Ralston, S., Johnston Marie, Marteau, T, Campbell Marion K, Miedzybrodzka, Z., Entwistle, Vikki A, Campbell, M.K, Theresa Marteau, Johnston, M, Stuart H Ralston, Langston, Anne L., Entwistle, V., Johnston, M., Francis Jill, Ralston Stuart H, MacLennan, G, Campbell, M. K., Marteau, T., Entwistle, VA, Johnston, Marie, Marion K Campbell, Maclennan, Graeme, Miedzybrodska, Zosia, McCallum, M, MacLennan Graeme, Keith Charnock, Francis, J, Charnock, K, Marteau, Theresa, MacLennan, G.   +81 more
core   +1 more source

Functional interaction between Sequestosome-1/p62 and Autophagy-Linked FYVE-containing protein WDFY3 in human osteoclasts [PDF]

, 2010
Peer ...
Hocking, Lynne J., Rogers, Michael J., Paul S. McCabe, Miep H. Helfrich, David J. Mellis, Mellis, David J., Lynne J. Hocking, Michael J. Rogers, Helfrich, Miep H., McCabe, Paul S.   +9 more
core   +1 more source