Results 21 to 30 of about 57,370,564 (168)
Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages
Infection and Immunity, 2018 Coxiella burnetii is the causative agent of human Q fever, a debilitating flu-like illness that can progress to chronic disease presenting as endocarditis. Following inhalation, C.
Caylin G. Winchell +5 more
semanticscholar +2 more sources
p62/sequestosome-1 as a severity-reflecting plasma biomarker in Charcot–Marie–Tooth disease type 1A
Scientific ReportsAutophagy is a self-degradation system for recycling to maintain homeostasis. p62/sequestosome-1 (p62) is an autophagy receptor that accumulates in neuroglia in neurodegenerative diseases.
Byeol-A Yoon +10 more
doaj +2 more sources
Molecular Neurobiology, 2023 Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis.
J. Davidson +20 more
semanticscholar +1 more source
Sequestosome 1/p62: A multitasker in the regulation of malignant tumor aggression (Review)
International Journal of Oncology, 2021 Sequestosome 1 (SQSTM1)/p62 is an adapter protein mainly involved in the transportation, degradation and destruction of various proteins that cooperates with components of autophagy and the ubiquitin-proteasome degradation pathway.
Jinlong Tang +6 more
semanticscholar +1 more source
Cell & Bioscience, 2021 Background Autophagy is required for oogenesis and plays a critical role in response to aging caused by oxidative stress. However, there have been no reports on regulation of cytoprotective autophagy in female germline stem cells (FGSCs) in response to ...
Xiao-Yan Yuan +4 more
semanticscholar +1 more source
Oncology Letters, 2022 p62/SQSTM1/Sequestosome-1 is an autophagic protein that serves a crucial role in cellular metabolism, proliferation and malignant growth. Notably, autophagy may influence the development and resistance to therapy of numerous types of human cancer. In the
A. Ieni +8 more
semanticscholar +1 more source
Toxicology Letters, 2021 Methylmercury (MeHg) is a hazardous environmental pollutant that causes serious toxicity in humans and animals, as well as proteotoxic stress. In our previous study, we found that MeHg induces the expression of p62/sequestosome 1 (p62) that selectively ...
Yasukazu Takanezawa +5 more
semanticscholar +1 more source
Dataset for the Sequestosome-1 antibody screening study
, 2023 This project contains the following underlying data included in a study aiming at characterizing antibodies for the Sequestosome-1 protein. The study is available on Zenodo (https://doi.org/10.5281/zenodo.4818440)
Laflamme, Carl
core +1 more source
Sequestosome 1/p62 – More than just a scaffold [PDF]
, 2007 The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/
Geetha, Thangiah +2 more
core +1 more source