Results 81 to 90 of about 10,729 (166)

Elevated Expression of Selenoprotein Synthesis Enzyme SEPHS2 Driven by ATF4 Promotes the Resistance to Ferroptosis in Prostate Cancer

MedComm, Volume 7, Issue 8, August 2026.
Under the treatment of ferroptosis inducers, the expression of SEPHS2 is upregulated, driven by ATF4, to increase the biosynthesis of selenoproteins (e.g., GPX4) to promote resistance to ferroptosis. ABSTRACT While it has been reported that antioxidant selenoproteins are crucial for anti‐ferroptosis in tumors, it remains unclear whether and how ...
Shijia Bao, Xinxing Du, Zhenkeke Tao, Huixiang Xiao, Jia Zhang, Zhenzhen Wen, Wei‐Qiang Gao, Baijun Dong, Yu‐Xiang Fang, Jianjun Sha   +9 more
wiley   +1 more source

Down‐Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury

Aging Cell, Volume 25, Issue 8, August 2026.
Aging is associated with impaired TFEB‐dependent autophagy in renal proximal tubular epithelial cells, leading to increased susceptibility to LPS‐induced injury and inflammation. Restoration of autophagy through TFEB activation or Tat–Beclin 1 treatment partially rescues autophagic function and confers protection against elderly sepsis‐associated acute
Yu Xiang, Ying Fu, Zhiwen Liu, Yu Han, Wenwen Wu, Juan Cai, Dongshan Zhang, Zheng Dong   +7 more
wiley   +1 more source

Moxibustion improves cardiac function by up-regulating autophagy-related proteins of cardiomyocytes in rats with chronic heart failure

针刺研究, 2019
Objective To observe the effect of moxibustion on cardiac function and the expression of autophagy-related proteins microtubule-associated protein 1 light chain 3(LC3)and selective autophagy receptor signaling adaptor sequestosome 1(SQSTM1/p62)in rats ...
LIU Na-na, JIA Xue-zhao, WANG Jing, ZHU Guo-qi, LI Dan, LI Qing-ling, MA Qiang   +6 more
doaj  

Dynamic Alterations in Testicular Autophagy in Prepubertal Mice

Journal of Developmental Biology
Autophagy has a potential regulatory effect on spermatogenesis and testicular development. Dynamic alterations in the testicular autophagy of prepubertal mice were analyzed, and the relationship between autophagy levels and testicular development was ...
Dong Zhang, Xiaoyun Pang, Zhenxing Yan, Weitao Dong, Zihao Fang, Jincheng Yang, Yanyan Wang, Li Xue, Jiahao Zhang, Chen Xue, Hongwei Duan, Xianghong Du, Yuxuan He   +12 more
doaj   +1 more source

Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization

Pharmacological Research
Most of the pyroptosis inhibitors targeted Gasdermin D (GSDMD) are functioning by restraining GSDMD-N (p30) oligomerization. For the first time, this work discovered a pyroptosis inhibitor taking effect by degrading p30 and GSDMD.
Danyue Li, Weilv Xu, Suhui He, Xinyue Li, Yumeng Wang, Qian Lv, Nan Chen, Lu Dong, Feng Guo, Fushan Shi   +9 more
doaj   +1 more source

SIRT5-mediated desuccinylation of the porcine deltacoronavirus M protein drives pexophagy to enhance viral proliferation.

PLoS Pathogens
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus capable of infecting various animal species, including humans. In this study, we explored the roles of sirtuins (SIRTs), a conserved family of protein deacylases and mono ...
Zhuang Li, Wenbing Tang, Yinan Lai, Chaoqun Chen, Puxian Fang, Yanrong Zhou, Liurong Fang, Shaobo Xiao   +7 more
doaj   +1 more source

ATG5 counteracts nutritional stress in human hepatoblastoma HepG2 cells by regulating autophagic flux

陆军军医大学学报
Objective‍　‍To investigate the effect of nutritional deficiency on autophagic flux in human hepatoblastoma HepG2 cells and the autophagy-dependent molecular pathway mediated by ATG5 against nutritional stress. Methods‍　‍Lentiviral siRNA knockdown of ATG5
ZHAO Lian, XIANG Dongyun, WU Huiyi
doaj   +1 more source

Autophagy deficiency protects against ocular hypertension and glaucoma

Autophagy Reports
Glaucoma encompasses a spectrum of disorders characterized by the chronic degeneration of retinal ganglion cell (RGC) axons and the progressive loss of RGCs, resulting in visual impairment.
Angela Dixon, Myoung Sup Shim, April Nettesheim, Aislyn Coyne, Chien-Chia Su, Haiyan Gong, Paloma B. Liton   +6 more
doaj   +1 more source

Laetiporus sulphureus polysaccharides ameliorate chronic alcoholic liver disease by activating p62/Nrf2, AMPK pathways and reshaping gut microbiota

Food Science and Human Wellness
One novel enzymatic-extractable polysaccharide (ES1) from fruiting bodies of Laetiporus sulphureus was obtained by isolation and purification using a DEAE Seplife FF chromatographic column and a Sephacryl S-400HR column.
Huajie Zhao, Liang Liu, Ningning Liu, Baoguo Deng, Min Li, Duan Li, Le Jia, Ge Wang, Fan Yang   +8 more
doaj   +1 more source

Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy

Antioxidants
Nuclear factor erythroid 2-related factor 2 (NRF2) has traditionally been framed as a Kelch-like ECH-associated protein 1 (KEAP1)-regulated stress-response transcription factor, but three observations now require a broader framework: NRF2 turnover is ...
Seung-Jin Kwag, Jin-Kwon Lee, Seung-Jun Lee, Jeongyun Hwang, Young-Sool Hah   +4 more
doaj   +1 more source