Results 111 to 120 of about 11,269 (219)

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Regulating Uniform Zinc Deposition via Covalently Tethered Imidazolium Cations in Polyacrylamide Hydrogel Electrolytes for Stable Aqueous Zinc Batteries

Advanced Energy Materials, EarlyView.
A positively charged polyionic liquid hydrogel electrolyte is developed for highly stable aqueous zinc‐ion batteries. Imidazolium cations anchored on the polymer framework create a dynamic electrostatic shield at the anode interface. This active layer effectively repels water molecules and guides uniform zinc deposition, thereby suppressing dendrite ...
Junlei Liu, Bingbing Han, Yuan Wang, Weiwei Hou, Yijing Gao, Yixiang Niu, Dianyu Tang, Rasheedat M. Mahamood, Ben Bin Xu, Cheng Zhang   +9 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

Single-cell structural biology with intracellular electron crystallography

Nature Communications
Intracellular crystallization is an emerging approach in structural biology that bypasses the need for protein purification. In 2024, the InCellCryst pipeline was introduced for structural studies of intracellular crystals by serial X-ray crystallography.
Štěpánka Bílá, Dominik Pinkas, Krishna Khakurel, Juliane Boger, Tomáš Bílý, Janos Hajdu, Zdeněk Franta, Iñaki de Diego Martinez, Roman Tuma, Lars Redecke, Vitaly Polovinkin   +10 more
doaj   +1 more source

[O─I─O]+ Halogen‐Bonded Complexes of Pyridine N‐Oxides

Angewandte Chemie, EarlyView.
The missing puzzle of 3‐center‐4‐electron halogen‐bonded complexes viz. [O─I─O]+ of pyridine N‐oxides are structurally characterized by x‐ray diffraction. Monodentate N‐oxide O‐atom acts as the halogen bond acceptor. Their solution complexations are characterized by 15N NMR spectroscopy.
Rakesh Puttreddy, Sergi Burguera, Antonio Frontera, Kari Rissanen   +3 more
wiley   +2 more sources

Reductive Activation of White Phosphorus to [P4]2–, [P2]2–, and a Formal P2– Radical by Rare‐Earth Dinitrogen Complexes

Angewandte Chemie, EarlyView.
Masked divalent yttrium and gadolinium dinitrogen complexes mediate the fragmentation of white phosphorus, converting P4 into discrete dimetallic complexes of [P4]2– and [P2]2– ligands, and an unprecedented monatomic P2– radical ligand. Structural, spectroscopic, magnetic, and DFT studies reveal insight into the bonding between these unusual Pn units ...
Arpan Mondal, Richard A. Layfield
wiley   +2 more sources

N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides

Angewandte Chemie, EarlyView.
N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison, Jonathan A. Andrews, Agamemnon E. Crumpton, Mireia Sidera Portela, Michael A. Clegg, Damien Valette, Michael C. Willis   +6 more
wiley   +2 more sources

Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study

Angewandte Chemie, EarlyView.
A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews, Thomas M. Richardson, Dean D. Roberts, Aitor Maestro, Timothy A. Hilton, Lia Sotorrios, Carlos Martín‐Fernández, Luca Craciunescu, Frederik Peschke, Aidan P. McKay, Stuart A. Macgregor, Glenn A. Burley, Allan J. B. Watson   +12 more
wiley   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources