Results 141 to 150 of about 29,886 (251)

Single-cell structural biology with intracellular electron crystallography

Nature Communications
Intracellular crystallization is an emerging approach in structural biology that bypasses the need for protein purification. In 2024, the InCellCryst pipeline was introduced for structural studies of intracellular crystals by serial X-ray crystallography.
Štěpánka Bílá, Dominik Pinkas, Krishna Khakurel, Juliane Boger, Tomáš Bílý, Janos Hajdu, Zdeněk Franta, Iñaki de Diego Martinez, Roman Tuma, Lars Redecke, Vitaly Polovinkin   +10 more
doaj   +1 more source

Radiation sensitive area detection device and method [PDF]

A radiation sensitive area detection device for use in conjunction with an X ray, ultraviolet or other radiation source is provided which comprises a phosphor containing film which releases a stored diffraction pattern image in response to incoming light
Carter, Daniel C., Hecht, Diana L., Witherow, William K.   +2 more
core   +1 more source

Thermally Controlled Chiral Supramolecular Polymorphism in Water

Angewandte Chemie International Edition, EarlyView.
Using an amphiphilic oligo(phenyleneethynylene) derivative, we establish LCST‐coupled chirality as a strategy to regulate thermoresponsive supramolecular polymorphism in water. At room temperature, AggI forms discrete assemblies that transform into elongated helical fibers (AggII) near the LCST and subsequently to sheet‐like structures (AggIII) at ...
Zulema Fernández, Yongsheng Li, Daniel Martínez, Julia Terlau, Myongsoo Lee, Bartolomé Soberats, Gustavo Fernández   +6 more
wiley   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

A standard descriptor for fixed-target serial crystallography. [PDF]

Acta Crystallogr D Struct Biol, 2023
Owen RL, de Sanctis D, Pearson AR, Beale JH.   +3 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Kilohertz serial crystallography with the JUNGFRAU detector at a fourth-generation synchrotron source. [PDF]

IUCrJ, 2023
Leonarski F, Nan J, Matej Z, Bertrand Q, Furrer A, Gorgisyan I, Bjelčić M, Kepa M, Glover H, Hinger V, Eriksson T, Cehovin A, Eguiraun M, Gasparotto P, Mozzanica A, Weinert T, Gonzalez A, Standfuss J, Wang M, Ursby T, Dworkowski F.   +20 more
europepmc   +1 more source

Room Temperature Serial Synchrotron Crystallography

Nihon Kessho Gakkaishi, 2022
Kazuya HASEGAWA, Takashi KUMASAKA
openaire   +1 more source

Micro-structured polymer fixed targets for serial crystallography at synchrotrons and XFELs. [PDF]

IUCrJ, 2023
Carrillo M, Mason TJ, Karpik A, Martiel I, Kepa MW, McAuley KE, Beale JH, Padeste C.   +7 more
europepmc   +1 more source

Increasing X-ray energy improves data quality in serial crystallography. [PDF]

J Synchrotron Radiat
Gu DH, Axford D, Beilsten-Edmands J, Jaho S, Owen RL.   +4 more
europepmc   +1 more source