Results 211 to 220 of about 29,886 (251)

<i>In situ</i> counter-diffusion crystallization and long-term crystal preservation in microfluidic fixed targets for serial crystallography. [PDF]

J Appl Crystallogr
Liu Z, Gu K, Shelby M, Roy D, Muniyappan S, Schmidt M, Narayanasamy SR, Coleman M, Frank M, Kuhl TL.   +9 more
europepmc   +1 more source

Memory of Chirality in Radical Addition–Translocation–Cyclization Cascades

Helvetica Chimica Acta, EarlyView.
Radical addition–translocation–cyclization cascades of chiral alkynes show striking memory of chirality (MoC), with strong retention of configuration when fast, polarity favored cyclization are involved. The most effective system employs a highly electron‐poor pentafluorobenzenesulfonyl group.
Christian Simon Gloor, Fabrice Dénès, Valentin Soulard, Philippe Renaud   +3 more
wiley   +1 more source

Dynamic three-dimensional structures of a metal-organic framework captured with femtosecond serial crystallography. [PDF]

Nat Chem
Kang J, Lee Y, Lee S, Ki H, Kim J, Gu J, Cha Y, Heo J, Lee KW, Kim SO, Park J, Park SY, Kim S, Ma R, Eom I, Kim M, Kim J, Lee JH, Ihee H.   +18 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Structural dynamics and functional cooperativity of human NQO1 by ambient temperature serial crystallography and simulations. [PDF]

Protein Sci
Grieco A, Boneta S, Gavira JA, Pey AL, Basu S, Orlans J, Sanctis D, Medina M, Martin-Garcia JM.   +8 more
europepmc   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Hundred-Picolitre Droplet on Demand Tape Drive and XES Prototypes for Time-Resolved Serial Crystallography at VMXi, Diamond Light Source

Aller P, Sanchez-Weatherby J, Bosman R, Devenish N, Hinchliffe P, Horrell S, Ip J, Littlewood R, Male A, Navarro EG, Neumann U, Kamps JJAG, Omar D, Parkinson L, Pandi M, Rubies N, Sandy J, Shilova A, Spencer J, Spiers J, Sutter JP, Telfer A, Thompson AJ, Tooke CL, Williams B, Zhou T, Hough MA, Orville AM.   +27 more
europepmc   +1 more source

Boosting the Photoluminescence of Au@Cu12 Nanoclusters via Strategic Fluorine‐Atom Ligand‐Shell Engineering

Journal of the Chinese Chemical Society, EarlyView.
The photophysical performance of gold‐doped copper‐rich nanoclusters can be tuned by surface functionalization. Subtle ligand modification enhances intermolecular interactions, thereby reducing nonradiative decay and markedly improving photoluminescence. Comparative photographs and quantum yield values (Φ = 55% vs.
Navya Indla, Wei‐Jung Yen, Yu‐Rong Ni, Jian‐Hong Liao, Xiaoping Wang, Michael N. Pillay, C. W. Liu   +6 more
wiley   +1 more source

A Personal Perspective on Metalloprotein Structure and the Future of Macromolecular X‐Ray Crystallography

Journal of the Chinese Chemical Society, EarlyView.
While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley   +1 more source

Isolation and Structural Characterization of Se‐Hügerschoff Intermediates Derived From 4‐Bromoaniline

Journal of Heterocyclic Chemistry, EarlyView.
Isolation and characterization of Se‐brominated Hügerschoff intermediates enable structural and mechanistic insight into seleno‐Hügerschoff cyclization to 2‐aminobenzoselenazoles. ABSTRACT A brominated intermediate within the Hügerschoff reaction has long been postulated but never directly observed.
Adam W. E. Stewart, Tom Fellows, Lucy Li, Craig J. Morton, Glen P. Carter, Jonathan M. White   +5 more
wiley   +1 more source