Results 191 to 200 of about 11,269 (219)

Tailoring Liquid Crystalline Self‐Assembly and Photophysical Properties of Unsymmetrical Fluorenones via Polar Terminal Groups

Chemistry – A European Journal, EarlyView.
Novel liquid crystalline fluorenones bearing various head groups were synthesized and characterized. By alteration of the head group, N, SmC, or SmA phases were obtained, and emission properties could be tuned depending on solvent or temperature. ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups ...
Falk Feucht, Franziska Müller, Johanna Osterbrink, Anna Zens, Yann Molard, Sabine Laschat   +5 more
wiley   +1 more source

Photochemical affinity switches to resolve ligand dissociation from a G protein-coupled receptor by time-resolved serial crystallography

Standfuss J, Glover H, Sassmannshausen T, Bertrand Q, Trabuco M, Slavov C, Bacchin A, Andres F, Kondo Y, Stipp R, Wranik M, Khusainov G, Kekilli D, Nan J, Gonzalez A, Cheng R, Neidhart W, Weinert T, Leonarski F, Dworkowski F, Kepa M, Wachtveitl J, Hennig M.   +22 more
europepmc   +1 more source

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Serial femtosecond crystallography

Nature Reviews Methods Primers, 2022
With the advent of X-ray Free Electron Lasers (XFELs), new, high-throughput serial crystallography techniques for macromolecular structure determination have emerged. Serial femtosecond crystallography (SFX) and related methods provide possibilities beyond canonical, single-crystal rotation crystallography by mitigating radiation damage and allowing ...
Benjamin Stauch, Ilme Schlichting, Vadim Cherezov   +2 more
exaly   +5 more sources

Lard Injection Matrix for Serial Crystallography [PDF]

International Journal of Molecular Sciences, 2020
Serial crystallography (SX) using X-ray free electron laser or synchrotron X-ray allows for the determination of structures, at room temperature, with reduced radiation damage. Moreover, it allows for the study of structural dynamics of macromolecules using a time-resolved pump-probe, as well as mix-and-inject experiments.
Ki Hyun Nam, Nam Ki Hyun
exaly   +3 more sources

Nanoflow electrospinning serial femtosecond crystallography [PDF]

Acta Crystallographica Section D: Biological Crystallography, 2012
An electrospun liquid microjet has been developed that delivers protein microcrystal suspensions at flow rates of 0.14–3.1 µl min−1to perform serial femtosecond crystallography (SFX) studies with X-ray lasers. Thermolysin microcrystals flowed at 0.17 µl min−1and diffracted to beyond 4 Å resolution, producing 14 000 indexable diffraction patterns, or ...
Richard Gildea, Uwe Bergmann, Junkô Yano   +2 more
exaly   +3 more sources

Sample Delivery Media for Serial Crystallography [PDF]

International Journal of Molecular Sciences, 2019
X-ray crystallographic methods can be used to visualize macromolecules at high resolution. This provides an understanding of molecular mechanisms and an insight into drug development and rational engineering of enzymes used in the industry. Although conventional synchrotron-based X-ray crystallography remains a powerful tool for understanding molecular
Ki Hyun Nam, Nam Ki Hyun
exaly   +3 more sources

Serial Crystallography for Structure-Based Drug Discovery [PDF]

Trends in Pharmacological Sciences, 2020
Rational drug discovery has greatly accelerated the development of safer and more efficacious therapeutics, assisted significantly by insights from experimentally determined 3D structures of ligands in complex with their targets. Serial crystallography (SX) with X-ray free-electron lasers has enabled structural determination using micrometer- or ...
Liang Jing
exaly   +3 more sources

Investigations of Photosensitive Proteins by Serial Crystallography

Biochemistry (Moscow), 2018
This review contains recent data on serial femtosecond X-ray crystallography (SFX), based on a femtosecond X-ray free electron laser, as well as, on the possibilities of its application for studying photosensitive proteins. Development of this method began rather recently, and it has already shown its effectiveness and some unique advantages over ...
G K, Selikhanov, M S, Fando, M V, Dontsova, A G, Gabdulkhakov   +3 more
openaire   +2 more sources

Serial Millisecond Crystallography of Membrane Proteins

2016
Serial femtosecond crystallography (SFX) at X-ray free-electron lasers (XFELs) is a powerful method to determine high-resolution structures of pharmaceutically relevant membrane proteins. Recently, the technology has been adapted to carry out serial millisecond crystallography (SMX) at synchrotron sources, where beamtime is more abundant.
Jaeger K, Dworkowski F, Nogly P, Milne C, Wang M, Standfuss J   +5 more
openaire   +3 more sources

Use of fixed targets for serial crystallography

In serial crystallography, large numbers of microcrystals are sequentially delivered to an X-ray beam and a diffraction pattern is obtained from each crystal. This serial approach was developed primarily for X-ray Free Electron Lasers (XFELs) where crystals are destroyed by the beam but is increasingly used in synchrotron experiments.
Sofia, Jaho, Danny, Axford, Do-Heon, Gu, Michael A, Hough, Robin L, Owen   +4 more
openaire   +2 more sources